Mapping the sequence mutations of the 2009 H1N1 influenza A virus neuraminidase relative to drug and antibody binding sites
In this work, we study the consequences of sequence variations of the "2009 H1N1" (swine or Mexican flu) influenza A virus strain neuraminidase for drug treatment and vaccination. We find that it is phylogenetically more closely related to European H1N1 swine flu and H5N1 avian flu rather...
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ftpubmed:oai:pubmedcentral.nih.gov:2691737 2023-05-15T15:34:23+02:00 Mapping the sequence mutations of the 2009 H1N1 influenza A virus neuraminidase relative to drug and antibody binding sites Maurer-Stroh, Sebastian Ma, Jianmin Lee, Raphael Tze Chuen Sirota, Fernanda L Eisenhaber, Frank 2009-05-20 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2691737 http://www.ncbi.nlm.nih.gov/pubmed/19457254 https://doi.org/10.1186/1745-6150-4-18 en eng BioMed Central http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2691737 http://www.ncbi.nlm.nih.gov/pubmed/19457254 http://dx.doi.org/10.1186/1745-6150-4-18 Copyright © 2009 Maurer-Stroh et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. CC-BY Discovery Notes Text 2009 ftpubmed https://doi.org/10.1186/1745-6150-4-18 2013-09-02T13:37:02Z In this work, we study the consequences of sequence variations of the "2009 H1N1" (swine or Mexican flu) influenza A virus strain neuraminidase for drug treatment and vaccination. We find that it is phylogenetically more closely related to European H1N1 swine flu and H5N1 avian flu rather than to the H1N1 counterparts in the Americas. Homology-based 3D structure modeling reveals that the novel mutations are preferentially located at the protein surface and do not interfere with the active site. The latter is the binding cavity for 3 currently used neuraminidase inhibitors: oseltamivir (Tamiflu®), zanamivir (Relenza®) and peramivir; thus, the drugs should remain effective for treatment. However, the antigenic regions of the neuraminidase relevant for vaccine development, serological typing and passive antibody treatment can differ from those of previous strains and already vary among patients. Text Avian flu PubMed Central (PMC) Biology Direct 4 1 18 |
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Discovery Notes Maurer-Stroh, Sebastian Ma, Jianmin Lee, Raphael Tze Chuen Sirota, Fernanda L Eisenhaber, Frank Mapping the sequence mutations of the 2009 H1N1 influenza A virus neuraminidase relative to drug and antibody binding sites |
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Discovery Notes |
description |
In this work, we study the consequences of sequence variations of the "2009 H1N1" (swine or Mexican flu) influenza A virus strain neuraminidase for drug treatment and vaccination. We find that it is phylogenetically more closely related to European H1N1 swine flu and H5N1 avian flu rather than to the H1N1 counterparts in the Americas. Homology-based 3D structure modeling reveals that the novel mutations are preferentially located at the protein surface and do not interfere with the active site. The latter is the binding cavity for 3 currently used neuraminidase inhibitors: oseltamivir (Tamiflu®), zanamivir (Relenza®) and peramivir; thus, the drugs should remain effective for treatment. However, the antigenic regions of the neuraminidase relevant for vaccine development, serological typing and passive antibody treatment can differ from those of previous strains and already vary among patients. |
format |
Text |
author |
Maurer-Stroh, Sebastian Ma, Jianmin Lee, Raphael Tze Chuen Sirota, Fernanda L Eisenhaber, Frank |
author_facet |
Maurer-Stroh, Sebastian Ma, Jianmin Lee, Raphael Tze Chuen Sirota, Fernanda L Eisenhaber, Frank |
author_sort |
Maurer-Stroh, Sebastian |
title |
Mapping the sequence mutations of the 2009 H1N1 influenza A virus neuraminidase relative to drug and antibody binding sites |
title_short |
Mapping the sequence mutations of the 2009 H1N1 influenza A virus neuraminidase relative to drug and antibody binding sites |
title_full |
Mapping the sequence mutations of the 2009 H1N1 influenza A virus neuraminidase relative to drug and antibody binding sites |
title_fullStr |
Mapping the sequence mutations of the 2009 H1N1 influenza A virus neuraminidase relative to drug and antibody binding sites |
title_full_unstemmed |
Mapping the sequence mutations of the 2009 H1N1 influenza A virus neuraminidase relative to drug and antibody binding sites |
title_sort |
mapping the sequence mutations of the 2009 h1n1 influenza a virus neuraminidase relative to drug and antibody binding sites |
publisher |
BioMed Central |
publishDate |
2009 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2691737 http://www.ncbi.nlm.nih.gov/pubmed/19457254 https://doi.org/10.1186/1745-6150-4-18 |
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Avian flu |
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Avian flu |
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2691737 http://www.ncbi.nlm.nih.gov/pubmed/19457254 http://dx.doi.org/10.1186/1745-6150-4-18 |
op_rights |
Copyright © 2009 Maurer-Stroh et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
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https://doi.org/10.1186/1745-6150-4-18 |
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Biology Direct |
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