Enrichment of the amino acid l-isovaline by aqueous alteration on CI and CM meteorite parent bodies
The distribution and enantiomeric composition of the 5-carbon (C5) amino acids found in CI-, CM-, and CR-type carbonaceous meteorites were investigated by using liquid chromatography fluorescence detection/TOF-MS coupled with o-phthaldialdehyde/N-acetyl-l-cysteine derivatization. A large l-enantiome...
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ftpubmed:oai:pubmedcentral.nih.gov:2667035 2023-05-15T13:34:58+02:00 Enrichment of the amino acid l-isovaline by aqueous alteration on CI and CM meteorite parent bodies Glavin, Daniel P. Dworkin, Jason P. 2009-04-07 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2667035 http://www.ncbi.nlm.nih.gov/pubmed/19289826 https://doi.org/10.1073/pnas.0811618106 en eng National Academy of Sciences http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2667035 http://www.ncbi.nlm.nih.gov/pubmed/19289826 http://dx.doi.org/10.1073/pnas.0811618106 Physical Sciences Text 2009 ftpubmed https://doi.org/10.1073/pnas.0811618106 2013-09-02T12:10:45Z The distribution and enantiomeric composition of the 5-carbon (C5) amino acids found in CI-, CM-, and CR-type carbonaceous meteorites were investigated by using liquid chromatography fluorescence detection/TOF-MS coupled with o-phthaldialdehyde/N-acetyl-l-cysteine derivatization. A large l-enantiomeric excess (ee) of the α-methyl amino acid isovaline was found in the CM meteorite Murchison (lee = 18.5 ± 2.6%) and the CI meteorite Orgueil (lee = 15.2 ± 4.0%). The measured value for Murchison is the largest enantiomeric excess in any meteorite reported to date, and the Orgueil measurement of an isovaline excess has not been reported previously for this or any CI meteorite. The l-isovaline enrichments in these two carbonaceous meteorites cannot be the result of interference from other C5 amino acid isomers present in the samples, analytical biases, or terrestrial amino acid contamination. We observed no l-isovaline enrichment for the most primitive unaltered Antarctic CR meteorites EET 92042 and QUE 99177. These results are inconsistent with UV circularly polarized light as the primary mechanism for l-isovaline enrichment and indicate that amplification of a small initial isovaline asymmetry in Murchison and Orgueil occurred during an extended aqueous alteration phase on the meteorite parent bodies. The large asymmetry in isovaline and other α-dialkyl amino acids found in altered CI and CM meteorites suggests that amino acids delivered by asteroids, comets, and their fragments would have biased the Earth's prebiotic organic inventory with left-handed molecules before the origin of life. Text Antarc* Antarctic PubMed Central (PMC) Antarctic Murchison ENVELOPE(144.250,144.250,-67.317,-67.317) Proceedings of the National Academy of Sciences 106 14 5487 5492 |
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English |
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Physical Sciences |
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Physical Sciences Glavin, Daniel P. Dworkin, Jason P. Enrichment of the amino acid l-isovaline by aqueous alteration on CI and CM meteorite parent bodies |
topic_facet |
Physical Sciences |
description |
The distribution and enantiomeric composition of the 5-carbon (C5) amino acids found in CI-, CM-, and CR-type carbonaceous meteorites were investigated by using liquid chromatography fluorescence detection/TOF-MS coupled with o-phthaldialdehyde/N-acetyl-l-cysteine derivatization. A large l-enantiomeric excess (ee) of the α-methyl amino acid isovaline was found in the CM meteorite Murchison (lee = 18.5 ± 2.6%) and the CI meteorite Orgueil (lee = 15.2 ± 4.0%). The measured value for Murchison is the largest enantiomeric excess in any meteorite reported to date, and the Orgueil measurement of an isovaline excess has not been reported previously for this or any CI meteorite. The l-isovaline enrichments in these two carbonaceous meteorites cannot be the result of interference from other C5 amino acid isomers present in the samples, analytical biases, or terrestrial amino acid contamination. We observed no l-isovaline enrichment for the most primitive unaltered Antarctic CR meteorites EET 92042 and QUE 99177. These results are inconsistent with UV circularly polarized light as the primary mechanism for l-isovaline enrichment and indicate that amplification of a small initial isovaline asymmetry in Murchison and Orgueil occurred during an extended aqueous alteration phase on the meteorite parent bodies. The large asymmetry in isovaline and other α-dialkyl amino acids found in altered CI and CM meteorites suggests that amino acids delivered by asteroids, comets, and their fragments would have biased the Earth's prebiotic organic inventory with left-handed molecules before the origin of life. |
format |
Text |
author |
Glavin, Daniel P. Dworkin, Jason P. |
author_facet |
Glavin, Daniel P. Dworkin, Jason P. |
author_sort |
Glavin, Daniel P. |
title |
Enrichment of the amino acid l-isovaline by aqueous alteration on CI and CM meteorite parent bodies |
title_short |
Enrichment of the amino acid l-isovaline by aqueous alteration on CI and CM meteorite parent bodies |
title_full |
Enrichment of the amino acid l-isovaline by aqueous alteration on CI and CM meteorite parent bodies |
title_fullStr |
Enrichment of the amino acid l-isovaline by aqueous alteration on CI and CM meteorite parent bodies |
title_full_unstemmed |
Enrichment of the amino acid l-isovaline by aqueous alteration on CI and CM meteorite parent bodies |
title_sort |
enrichment of the amino acid l-isovaline by aqueous alteration on ci and cm meteorite parent bodies |
publisher |
National Academy of Sciences |
publishDate |
2009 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2667035 http://www.ncbi.nlm.nih.gov/pubmed/19289826 https://doi.org/10.1073/pnas.0811618106 |
long_lat |
ENVELOPE(144.250,144.250,-67.317,-67.317) |
geographic |
Antarctic Murchison |
geographic_facet |
Antarctic Murchison |
genre |
Antarc* Antarctic |
genre_facet |
Antarc* Antarctic |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2667035 http://www.ncbi.nlm.nih.gov/pubmed/19289826 http://dx.doi.org/10.1073/pnas.0811618106 |
op_doi |
https://doi.org/10.1073/pnas.0811618106 |
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Proceedings of the National Academy of Sciences |
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106 |
container_issue |
14 |
container_start_page |
5487 |
op_container_end_page |
5492 |
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1766059628072796160 |