The cullin7 E3 ubiquitin ligase: A novel player in growth control
Cullin7 (CUL7) is a molecular scaffold that organizes an E3 ubiquitin ligase containing the F-box protein Fbw8, Skp1 and the ROC1 RING finger protein. Dysregulation of the CUL7 E3 Ligase has been directly linked to hereditary human diseases as cul7 germline mutations were found in patients with auto...
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ftpubmed:oai:pubmedcentral.nih.gov:2637179 2023-05-15T18:45:16+02:00 The cullin7 E3 ubiquitin ligase: A novel player in growth control Sarikas, Antonio Xu, Xinsong Field, Loren J. Pan, Zhen-Qiang 2008-10-04 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637179 http://www.ncbi.nlm.nih.gov/pubmed/18927510 en eng http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637179 http://www.ncbi.nlm.nih.gov/pubmed/18927510 Article Text 2008 ftpubmed 2013-09-02T10:34:28Z Cullin7 (CUL7) is a molecular scaffold that organizes an E3 ubiquitin ligase containing the F-box protein Fbw8, Skp1 and the ROC1 RING finger protein. Dysregulation of the CUL7 E3 Ligase has been directly linked to hereditary human diseases as cul7 germline mutations were found in patients with autosomal-recessive 3-M and Yakuts short stature syndromes, which are characterized by profound pre- and postnatal growth retardation. In addition, genetic ablation of CUL7 in mice resulted in intra-uterine growth retardation and perinatal lethality, underscoring its importance for growth regulation. The recent identification of insulin receptor substrate 1, a critical mediator of insulin and insulin-like growth factor-1 signaling, as the proteolytic target of the CUL7 E3 ligase, provided a molecular link between CUL7 and a well-established growth regulatory pathway. This result, coupled with other studies demonstrating interactions between CUL7 and the p53 tumor suppressor protein, as well as the simian virus 40 large T antigen oncoprotein, further implicated CUL7 as a novel player in growth control and suggested pathomechanistic insights into CUL7-linked growth retardation syndromes. Text Yakuts PubMed Central (PMC) |
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Article Sarikas, Antonio Xu, Xinsong Field, Loren J. Pan, Zhen-Qiang The cullin7 E3 ubiquitin ligase: A novel player in growth control |
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Cullin7 (CUL7) is a molecular scaffold that organizes an E3 ubiquitin ligase containing the F-box protein Fbw8, Skp1 and the ROC1 RING finger protein. Dysregulation of the CUL7 E3 Ligase has been directly linked to hereditary human diseases as cul7 germline mutations were found in patients with autosomal-recessive 3-M and Yakuts short stature syndromes, which are characterized by profound pre- and postnatal growth retardation. In addition, genetic ablation of CUL7 in mice resulted in intra-uterine growth retardation and perinatal lethality, underscoring its importance for growth regulation. The recent identification of insulin receptor substrate 1, a critical mediator of insulin and insulin-like growth factor-1 signaling, as the proteolytic target of the CUL7 E3 ligase, provided a molecular link between CUL7 and a well-established growth regulatory pathway. This result, coupled with other studies demonstrating interactions between CUL7 and the p53 tumor suppressor protein, as well as the simian virus 40 large T antigen oncoprotein, further implicated CUL7 as a novel player in growth control and suggested pathomechanistic insights into CUL7-linked growth retardation syndromes. |
format |
Text |
author |
Sarikas, Antonio Xu, Xinsong Field, Loren J. Pan, Zhen-Qiang |
author_facet |
Sarikas, Antonio Xu, Xinsong Field, Loren J. Pan, Zhen-Qiang |
author_sort |
Sarikas, Antonio |
title |
The cullin7 E3 ubiquitin ligase: A novel player in growth control |
title_short |
The cullin7 E3 ubiquitin ligase: A novel player in growth control |
title_full |
The cullin7 E3 ubiquitin ligase: A novel player in growth control |
title_fullStr |
The cullin7 E3 ubiquitin ligase: A novel player in growth control |
title_full_unstemmed |
The cullin7 E3 ubiquitin ligase: A novel player in growth control |
title_sort |
cullin7 e3 ubiquitin ligase: a novel player in growth control |
publishDate |
2008 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637179 http://www.ncbi.nlm.nih.gov/pubmed/18927510 |
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Yakuts |
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Yakuts |
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637179 http://www.ncbi.nlm.nih.gov/pubmed/18927510 |
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