Reindeer papillomavirus transforming properties correlate with a highly conserved E5 region.
A papillomavirus was isolated from the epithelial layer of a cutaneous fibropapilloma on a Swedish reindeer (Rangifer tarandus). Reindeer papillomavirus (RPV) is morphologically indistinguishable from other papillomaviruses, but the restriction enzyme cleavage pattern of its genome is different. No...
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ftpubmed:oai:pubmedcentral.nih.gov:255934 2023-05-15T18:04:21+02:00 Reindeer papillomavirus transforming properties correlate with a highly conserved E5 region. Moreno-Lopez, J Ahola, H Eriksson, A Bergman, P Pettersson, U 1987-11 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC255934 http://www.ncbi.nlm.nih.gov/pubmed/2822949 en eng http://www.ncbi.nlm.nih.gov/pmc/articles/PMC255934 http://www.ncbi.nlm.nih.gov/pubmed/2822949 Research Article Text 1987 ftpubmed 2013-08-29T16:39:41Z A papillomavirus was isolated from the epithelial layer of a cutaneous fibropapilloma on a Swedish reindeer (Rangifer tarandus). Reindeer papillomavirus (RPV) is morphologically indistinguishable from other papillomaviruses, but the restriction enzyme cleavage pattern of its genome is different. No sequence homology was detected between RPV DNA and the DNAs of bovine papillomavirus type 1 (BPV-1) and avian papillomavirus when hybridization was performed under stringent conditions. However, the RPV genome hybridized to the genome of the European elk papillomavirus and the deer papillomavirus under stringent conditions. A physical map of the RPV genome was constructed, and selected regions of the genome, covering the open translational reading frame (ORF) E5 and part of the E1 and L1 ORFs, were studied by nucleotide sequence analysis. The results made it possible to align the RPV genome with the genome of BPV-1. The E5 ORF of RPV has the potential to encode a 44-amino-acid, exceptionally hydrophobic polypeptide which is very similar to the E5 polypeptides of BPV-1 and deer and European elk papillomaviruses. RPV is oncogenic for hamsters and transforms C127 mouse cells in vitro. Several virus-specific mRNAs were detected in RPV-transformed C127 cells. Text Rangifer tarandus PubMed Central (PMC) |
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Research Article Moreno-Lopez, J Ahola, H Eriksson, A Bergman, P Pettersson, U Reindeer papillomavirus transforming properties correlate with a highly conserved E5 region. |
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Research Article |
description |
A papillomavirus was isolated from the epithelial layer of a cutaneous fibropapilloma on a Swedish reindeer (Rangifer tarandus). Reindeer papillomavirus (RPV) is morphologically indistinguishable from other papillomaviruses, but the restriction enzyme cleavage pattern of its genome is different. No sequence homology was detected between RPV DNA and the DNAs of bovine papillomavirus type 1 (BPV-1) and avian papillomavirus when hybridization was performed under stringent conditions. However, the RPV genome hybridized to the genome of the European elk papillomavirus and the deer papillomavirus under stringent conditions. A physical map of the RPV genome was constructed, and selected regions of the genome, covering the open translational reading frame (ORF) E5 and part of the E1 and L1 ORFs, were studied by nucleotide sequence analysis. The results made it possible to align the RPV genome with the genome of BPV-1. The E5 ORF of RPV has the potential to encode a 44-amino-acid, exceptionally hydrophobic polypeptide which is very similar to the E5 polypeptides of BPV-1 and deer and European elk papillomaviruses. RPV is oncogenic for hamsters and transforms C127 mouse cells in vitro. Several virus-specific mRNAs were detected in RPV-transformed C127 cells. |
format |
Text |
author |
Moreno-Lopez, J Ahola, H Eriksson, A Bergman, P Pettersson, U |
author_facet |
Moreno-Lopez, J Ahola, H Eriksson, A Bergman, P Pettersson, U |
author_sort |
Moreno-Lopez, J |
title |
Reindeer papillomavirus transforming properties correlate with a highly conserved E5 region. |
title_short |
Reindeer papillomavirus transforming properties correlate with a highly conserved E5 region. |
title_full |
Reindeer papillomavirus transforming properties correlate with a highly conserved E5 region. |
title_fullStr |
Reindeer papillomavirus transforming properties correlate with a highly conserved E5 region. |
title_full_unstemmed |
Reindeer papillomavirus transforming properties correlate with a highly conserved E5 region. |
title_sort |
reindeer papillomavirus transforming properties correlate with a highly conserved e5 region. |
publishDate |
1987 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC255934 http://www.ncbi.nlm.nih.gov/pubmed/2822949 |
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Rangifer tarandus |
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Rangifer tarandus |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC255934 http://www.ncbi.nlm.nih.gov/pubmed/2822949 |
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1766175698321408000 |