Association of Albuminuria and Cancer Incidence
Albuminuria, which is associated with noncardiovascular mortality, might be a result of altered vascular permeability caused by cytokines and other tumor cell products. The aim of this population-based, longitudinal study was to examine whether elevated albumin-to-creatinine ratio (ACR) is associate...
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ftpubmed:oai:pubmedcentral.nih.gov:2386729 2023-05-15T18:34:35+02:00 Association of Albuminuria and Cancer Incidence Jørgensen, Lone Heuch, Ivar Jenssen, Trond Jacobsen, Bjarne K. 2008-05 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2386729 http://www.ncbi.nlm.nih.gov/pubmed/18256361 https://doi.org/10.1681/ASN.2007060712 en eng American Society of Nephrology http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2386729 http://www.ncbi.nlm.nih.gov/pubmed/18256361 http://dx.doi.org/10.1681/ASN.2007060712 Copyright © 2008 by the American Society of Nephrology Clinical Epidemiology Text 2008 ftpubmed https://doi.org/10.1681/ASN.2007060712 2013-09-01T22:29:02Z Albuminuria, which is associated with noncardiovascular mortality, might be a result of altered vascular permeability caused by cytokines and other tumor cell products. The aim of this population-based, longitudinal study was to examine whether elevated albumin-to-creatinine ratio (ACR) is associated with cancer incidence. A total of 5425 participants without diabetes or previous cancer in the Tromsø Study were followed; 590 had a first diagnosis of cancer during 10.3 yr of follow-up. The ACR at baseline significantly correlated with the incidence of cancer, even after adjustment for age, gender, body mass index, physical activity, and smoking (P < 0.001). Participants with ACR in the highest quintile were 8.3- and 2.4-fold more likely to receive a diagnosis of bladder cancer and lung cancer, respectively, compared with those with ACR in the lowest quintile after similar adjustments. It is concluded that albuminuria is associated with cancer incidence in individuals without a history of diabetes, macroalbuminuria, or previous cancer and that it might confer risks of varying magnitude for different types of cancer. Text Tromsø PubMed Central (PMC) Tromsø Journal of the American Society of Nephrology 19 5 992 998 |
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Clinical Epidemiology |
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Clinical Epidemiology Jørgensen, Lone Heuch, Ivar Jenssen, Trond Jacobsen, Bjarne K. Association of Albuminuria and Cancer Incidence |
topic_facet |
Clinical Epidemiology |
description |
Albuminuria, which is associated with noncardiovascular mortality, might be a result of altered vascular permeability caused by cytokines and other tumor cell products. The aim of this population-based, longitudinal study was to examine whether elevated albumin-to-creatinine ratio (ACR) is associated with cancer incidence. A total of 5425 participants without diabetes or previous cancer in the Tromsø Study were followed; 590 had a first diagnosis of cancer during 10.3 yr of follow-up. The ACR at baseline significantly correlated with the incidence of cancer, even after adjustment for age, gender, body mass index, physical activity, and smoking (P < 0.001). Participants with ACR in the highest quintile were 8.3- and 2.4-fold more likely to receive a diagnosis of bladder cancer and lung cancer, respectively, compared with those with ACR in the lowest quintile after similar adjustments. It is concluded that albuminuria is associated with cancer incidence in individuals without a history of diabetes, macroalbuminuria, or previous cancer and that it might confer risks of varying magnitude for different types of cancer. |
format |
Text |
author |
Jørgensen, Lone Heuch, Ivar Jenssen, Trond Jacobsen, Bjarne K. |
author_facet |
Jørgensen, Lone Heuch, Ivar Jenssen, Trond Jacobsen, Bjarne K. |
author_sort |
Jørgensen, Lone |
title |
Association of Albuminuria and Cancer Incidence |
title_short |
Association of Albuminuria and Cancer Incidence |
title_full |
Association of Albuminuria and Cancer Incidence |
title_fullStr |
Association of Albuminuria and Cancer Incidence |
title_full_unstemmed |
Association of Albuminuria and Cancer Incidence |
title_sort |
association of albuminuria and cancer incidence |
publisher |
American Society of Nephrology |
publishDate |
2008 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2386729 http://www.ncbi.nlm.nih.gov/pubmed/18256361 https://doi.org/10.1681/ASN.2007060712 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2386729 http://www.ncbi.nlm.nih.gov/pubmed/18256361 http://dx.doi.org/10.1681/ASN.2007060712 |
op_rights |
Copyright © 2008 by the American Society of Nephrology |
op_doi |
https://doi.org/10.1681/ASN.2007060712 |
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Journal of the American Society of Nephrology |
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19 |
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5 |
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992 |
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998 |
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1766219396082040832 |