Major Quantitative Trait Loci Affect Resistance to Infectious Pancreatic Necrosis in Atlantic Salmon (Salmo salar)
Infectious pancreatic necrosis (IPN) is a viral disease currently presenting a major problem in the production of Atlantic salmon (Salmon salar). IPN can cause significant mortality to salmon fry within freshwater hatcheries and to smolts following transfer to seawater, although challenged populatio...
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ftpubmed:oai:pubmedcentral.nih.gov:2248365 2023-05-15T15:30:35+02:00 Major Quantitative Trait Loci Affect Resistance to Infectious Pancreatic Necrosis in Atlantic Salmon (Salmo salar) Houston, Ross D. Haley, Chris S. Hamilton, Alastair Guy, Derrick R. Tinch, Alan E. Taggart, John B. McAndrew, Brendan J. Bishop, Stephen C. 2008-02 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2248365 http://www.ncbi.nlm.nih.gov/pubmed/18245341 https://doi.org/10.1534/genetics.107.082974 en eng Genetics Society of America http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2248365 http://www.ncbi.nlm.nih.gov/pubmed/18245341 http://dx.doi.org/10.1534/genetics.107.082974 Copyright © 2008 by the Genetics Society of America Investigations Text 2008 ftpubmed https://doi.org/10.1534/genetics.107.082974 2013-09-01T15:32:47Z Infectious pancreatic necrosis (IPN) is a viral disease currently presenting a major problem in the production of Atlantic salmon (Salmon salar). IPN can cause significant mortality to salmon fry within freshwater hatcheries and to smolts following transfer to seawater, although challenged populations show clear genetic variation in resistance. To determine whether this genetic variation includes loci of major effect, a genomewide quantitative trait loci (QTL) scan was performed within 10 full-sib families that had received a natural seawater IPN challenge. To utilize the large difference between Atlantic salmon male and female recombination rates, a two-stage mapping strategy was employed. Initially, a sire-based QTL analysis was used to detect linkage groups with significant effects on IPN resistance, using two to three microsatellite markers per linkage group. A dam-based analysis with additional markers was then used to confirm and position any detected QTL. Two genomewide significant QTL and one suggestive QTL were detected in the genome scan. The most significant QTL was mapped to linkage group 21 and was significant at the genomewide level in both the sire and the dam-based analyses. The identified QTL can be applied in marker-assisted selection programs to improve the resistance of salmon to IPN and reduce disease-related mortality. Text Atlantic salmon Salmo salar PubMed Central (PMC) Genetics 178 2 1109 1115 |
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Investigations Houston, Ross D. Haley, Chris S. Hamilton, Alastair Guy, Derrick R. Tinch, Alan E. Taggart, John B. McAndrew, Brendan J. Bishop, Stephen C. Major Quantitative Trait Loci Affect Resistance to Infectious Pancreatic Necrosis in Atlantic Salmon (Salmo salar) |
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Investigations |
description |
Infectious pancreatic necrosis (IPN) is a viral disease currently presenting a major problem in the production of Atlantic salmon (Salmon salar). IPN can cause significant mortality to salmon fry within freshwater hatcheries and to smolts following transfer to seawater, although challenged populations show clear genetic variation in resistance. To determine whether this genetic variation includes loci of major effect, a genomewide quantitative trait loci (QTL) scan was performed within 10 full-sib families that had received a natural seawater IPN challenge. To utilize the large difference between Atlantic salmon male and female recombination rates, a two-stage mapping strategy was employed. Initially, a sire-based QTL analysis was used to detect linkage groups with significant effects on IPN resistance, using two to three microsatellite markers per linkage group. A dam-based analysis with additional markers was then used to confirm and position any detected QTL. Two genomewide significant QTL and one suggestive QTL were detected in the genome scan. The most significant QTL was mapped to linkage group 21 and was significant at the genomewide level in both the sire and the dam-based analyses. The identified QTL can be applied in marker-assisted selection programs to improve the resistance of salmon to IPN and reduce disease-related mortality. |
format |
Text |
author |
Houston, Ross D. Haley, Chris S. Hamilton, Alastair Guy, Derrick R. Tinch, Alan E. Taggart, John B. McAndrew, Brendan J. Bishop, Stephen C. |
author_facet |
Houston, Ross D. Haley, Chris S. Hamilton, Alastair Guy, Derrick R. Tinch, Alan E. Taggart, John B. McAndrew, Brendan J. Bishop, Stephen C. |
author_sort |
Houston, Ross D. |
title |
Major Quantitative Trait Loci Affect Resistance to Infectious Pancreatic Necrosis in Atlantic Salmon (Salmo salar) |
title_short |
Major Quantitative Trait Loci Affect Resistance to Infectious Pancreatic Necrosis in Atlantic Salmon (Salmo salar) |
title_full |
Major Quantitative Trait Loci Affect Resistance to Infectious Pancreatic Necrosis in Atlantic Salmon (Salmo salar) |
title_fullStr |
Major Quantitative Trait Loci Affect Resistance to Infectious Pancreatic Necrosis in Atlantic Salmon (Salmo salar) |
title_full_unstemmed |
Major Quantitative Trait Loci Affect Resistance to Infectious Pancreatic Necrosis in Atlantic Salmon (Salmo salar) |
title_sort |
major quantitative trait loci affect resistance to infectious pancreatic necrosis in atlantic salmon (salmo salar) |
publisher |
Genetics Society of America |
publishDate |
2008 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2248365 http://www.ncbi.nlm.nih.gov/pubmed/18245341 https://doi.org/10.1534/genetics.107.082974 |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2248365 http://www.ncbi.nlm.nih.gov/pubmed/18245341 http://dx.doi.org/10.1534/genetics.107.082974 |
op_rights |
Copyright © 2008 by the Genetics Society of America |
op_doi |
https://doi.org/10.1534/genetics.107.082974 |
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Genetics |
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178 |
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2 |
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1109 |
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1115 |
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1766361037822492672 |