Correlation of T cell receptor V beta gene family with MHC restriction
We have studied a panel of DBA/2 T cell clones specific for sperm whale myoglobin (SpW Mb) for TCR (T cell receptor) beta chain gene expression by FACS analysis using the monoclonal antibodies F23.1 and KJ16 specific for the V beta 8 family of the TCR beta chain genes. Within any given specificity g...
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1987
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ftpubmed:oai:pubmedcentral.nih.gov:2189600 2023-05-15T18:26:43+02:00 Correlation of T cell receptor V beta gene family with MHC restriction 1987-08-01 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189600 http://www.ncbi.nlm.nih.gov/pubmed/3598467 en eng The Rockefeller University Press http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189600 http://www.ncbi.nlm.nih.gov/pubmed/3598467 Articles Text 1987 ftpubmed 2013-09-01T12:40:04Z We have studied a panel of DBA/2 T cell clones specific for sperm whale myoglobin (SpW Mb) for TCR (T cell receptor) beta chain gene expression by FACS analysis using the monoclonal antibodies F23.1 and KJ16 specific for the V beta 8 family of the TCR beta chain genes. Within any given specificity group, all the clones tested came from different mice. 10 of 11 I-Ed-restricted SpW Mb-specific T cell clones were F23.1+; 8 of these were also KJ16+. Only one of the three I-Ad- restricted clones tested was F23.1+; this clone was KJ16 negative. This study has demonstrated that I-Ed-restricted T cell clones from DBA/2 mice express members of the TCR V beta 8 family irrespective of the epitopes of SpW Mb recognized. These data suggest an apparent correlation between TCR V beta expression and MHC restriction. Text Sperm whale PubMed Central (PMC) |
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Articles Correlation of T cell receptor V beta gene family with MHC restriction |
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We have studied a panel of DBA/2 T cell clones specific for sperm whale myoglobin (SpW Mb) for TCR (T cell receptor) beta chain gene expression by FACS analysis using the monoclonal antibodies F23.1 and KJ16 specific for the V beta 8 family of the TCR beta chain genes. Within any given specificity group, all the clones tested came from different mice. 10 of 11 I-Ed-restricted SpW Mb-specific T cell clones were F23.1+; 8 of these were also KJ16+. Only one of the three I-Ad- restricted clones tested was F23.1+; this clone was KJ16 negative. This study has demonstrated that I-Ed-restricted T cell clones from DBA/2 mice express members of the TCR V beta 8 family irrespective of the epitopes of SpW Mb recognized. These data suggest an apparent correlation between TCR V beta expression and MHC restriction. |
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Text |
title |
Correlation of T cell receptor V beta gene family with MHC restriction |
title_short |
Correlation of T cell receptor V beta gene family with MHC restriction |
title_full |
Correlation of T cell receptor V beta gene family with MHC restriction |
title_fullStr |
Correlation of T cell receptor V beta gene family with MHC restriction |
title_full_unstemmed |
Correlation of T cell receptor V beta gene family with MHC restriction |
title_sort |
correlation of t cell receptor v beta gene family with mhc restriction |
publisher |
The Rockefeller University Press |
publishDate |
1987 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189600 http://www.ncbi.nlm.nih.gov/pubmed/3598467 |
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Sperm whale |
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Sperm whale |
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2189600 http://www.ncbi.nlm.nih.gov/pubmed/3598467 |
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1766208697773588480 |