Natural selection acts on Atlantic salmon major histocompatibility (MH) variability in the wild
Pathogen-driven balancing selection is thought to maintain polymorphism in major histocompatibility (MH) genes. However, there have been few empirical demonstrations of selection acting on MH loci in natural populations. To determine whether natural selection on MH genes has fitness consequences for...
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ftpubmed:oai:pubmedcentral.nih.gov:2093966 2023-05-15T15:30:36+02:00 Natural selection acts on Atlantic salmon major histocompatibility (MH) variability in the wild de Eyto, Elvira McGinnity, Philip Consuegra, Sofia Coughlan, Jamie Tufto, Jarle Farrell, Killian Megens, Hendrik-Jan Jordan, William Cross, Tom Stet, René J.M 2007-01-04 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2093966 http://www.ncbi.nlm.nih.gov/pubmed/17251111 https://doi.org/10.1098/rspb.2006.0053 en eng The Royal Society http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2093966 http://www.ncbi.nlm.nih.gov/pubmed/17251111 http://dx.doi.org/10.1098/rspb.2006.0053 © 2007 The Royal Society Research Article Text 2007 ftpubmed https://doi.org/10.1098/rspb.2006.0053 2013-09-01T08:00:12Z Pathogen-driven balancing selection is thought to maintain polymorphism in major histocompatibility (MH) genes. However, there have been few empirical demonstrations of selection acting on MH loci in natural populations. To determine whether natural selection on MH genes has fitness consequences for wild Atlantic salmon in natural conditions, we compared observed genotype frequencies of Atlantic salmon (Salmo salar) surviving in a river six months after their introduction as eggs with frequencies expected from parental crosses. We found significant differences between expected and observed genotype frequencies at the MH class II alpha locus, but not at a MH class I-linked microsatellite or at seven non-MH-linked microsatellite loci. We therefore conclude that selection at the MH class II alpha locus was a result of disease-mediated natural selection, rather than any demographic event. We also show that survival was associated with additive allelic effects at the MH class II alpha locus. Our results have implications for both the conservation of wild salmon stocks and the management of disease in hatchery fish. We conclude that natural or hatchery populations have the best chance of dealing with episodic and variable disease challenges if MH genetic variation is preserved both within and among populations. Text Atlantic salmon Salmo salar PubMed Central (PMC) Proceedings of the Royal Society B: Biological Sciences 274 1611 861 869 |
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Research Article |
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Research Article de Eyto, Elvira McGinnity, Philip Consuegra, Sofia Coughlan, Jamie Tufto, Jarle Farrell, Killian Megens, Hendrik-Jan Jordan, William Cross, Tom Stet, René J.M Natural selection acts on Atlantic salmon major histocompatibility (MH) variability in the wild |
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Research Article |
description |
Pathogen-driven balancing selection is thought to maintain polymorphism in major histocompatibility (MH) genes. However, there have been few empirical demonstrations of selection acting on MH loci in natural populations. To determine whether natural selection on MH genes has fitness consequences for wild Atlantic salmon in natural conditions, we compared observed genotype frequencies of Atlantic salmon (Salmo salar) surviving in a river six months after their introduction as eggs with frequencies expected from parental crosses. We found significant differences between expected and observed genotype frequencies at the MH class II alpha locus, but not at a MH class I-linked microsatellite or at seven non-MH-linked microsatellite loci. We therefore conclude that selection at the MH class II alpha locus was a result of disease-mediated natural selection, rather than any demographic event. We also show that survival was associated with additive allelic effects at the MH class II alpha locus. Our results have implications for both the conservation of wild salmon stocks and the management of disease in hatchery fish. We conclude that natural or hatchery populations have the best chance of dealing with episodic and variable disease challenges if MH genetic variation is preserved both within and among populations. |
format |
Text |
author |
de Eyto, Elvira McGinnity, Philip Consuegra, Sofia Coughlan, Jamie Tufto, Jarle Farrell, Killian Megens, Hendrik-Jan Jordan, William Cross, Tom Stet, René J.M |
author_facet |
de Eyto, Elvira McGinnity, Philip Consuegra, Sofia Coughlan, Jamie Tufto, Jarle Farrell, Killian Megens, Hendrik-Jan Jordan, William Cross, Tom Stet, René J.M |
author_sort |
de Eyto, Elvira |
title |
Natural selection acts on Atlantic salmon major histocompatibility (MH) variability in the wild |
title_short |
Natural selection acts on Atlantic salmon major histocompatibility (MH) variability in the wild |
title_full |
Natural selection acts on Atlantic salmon major histocompatibility (MH) variability in the wild |
title_fullStr |
Natural selection acts on Atlantic salmon major histocompatibility (MH) variability in the wild |
title_full_unstemmed |
Natural selection acts on Atlantic salmon major histocompatibility (MH) variability in the wild |
title_sort |
natural selection acts on atlantic salmon major histocompatibility (mh) variability in the wild |
publisher |
The Royal Society |
publishDate |
2007 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2093966 http://www.ncbi.nlm.nih.gov/pubmed/17251111 https://doi.org/10.1098/rspb.2006.0053 |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2093966 http://www.ncbi.nlm.nih.gov/pubmed/17251111 http://dx.doi.org/10.1098/rspb.2006.0053 |
op_rights |
© 2007 The Royal Society |
op_doi |
https://doi.org/10.1098/rspb.2006.0053 |
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Proceedings of the Royal Society B: Biological Sciences |
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274 |
container_issue |
1611 |
container_start_page |
861 |
op_container_end_page |
869 |
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1766361057228488704 |