Genetic Variation and Population Structure in Native Americans
We examined genetic diversity and population structure in the American landmass using 678 autosomal microsatellite markers genotyped in 422 individuals representing 24 Native American populations sampled from North, Central, and South America. These data were analyzed jointly with similar data avail...
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ftpubmed:oai:pubmedcentral.nih.gov:2082466 2023-05-15T15:44:14+02:00 Genetic Variation and Population Structure in Native Americans Wang, Sijia Lewis, Cecil M Jakobsson, Mattias Ramachandran, Sohini Ray, Nicolas Bedoya, Gabriel Rojas, Winston Parra, Maria V Molina, Julio A Gallo, Carla Mazzotti, Guido Poletti, Giovanni Hill, Kim Hurtado, Ana M Labuda, Damian Klitz, William Barrantes, Ramiro Bortolini, Maria Cátira Salzano, Francisco M Petzl-Erler, Maria Luiza Tsuneto, Luiza T Llop, Elena Rothhammer, Francisco Excoffier, Laurent Feldman, Marcus W Rosenberg, Noah A Ruiz-Linares, Andrés 2007-11 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2082466 http://www.ncbi.nlm.nih.gov/pubmed/18039031 https://doi.org/10.1371/journal.pgen.0030185 en eng Public Library of Science http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2082466 http://www.ncbi.nlm.nih.gov/pubmed/18039031 http://dx.doi.org/10.1371/journal.pgen.0030185 Copyright: © 2007 Wang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. CC-BY Research Article Text 2007 ftpubmed https://doi.org/10.1371/journal.pgen.0030185 2013-09-01T07:26:15Z We examined genetic diversity and population structure in the American landmass using 678 autosomal microsatellite markers genotyped in 422 individuals representing 24 Native American populations sampled from North, Central, and South America. These data were analyzed jointly with similar data available in 54 other indigenous populations worldwide, including an additional five Native American groups. The Native American populations have lower genetic diversity and greater differentiation than populations from other continental regions. We observe gradients both of decreasing genetic diversity as a function of geographic distance from the Bering Strait and of decreasing genetic similarity to Siberians—signals of the southward dispersal of human populations from the northwestern tip of the Americas. We also observe evidence of: (1) a higher level of diversity and lower level of population structure in western South America compared to eastern South America, (2) a relative lack of differentiation between Mesoamerican and Andean populations, (3) a scenario in which coastal routes were easier for migrating peoples to traverse in comparison with inland routes, and (4) a partial agreement on a local scale between genetic similarity and the linguistic classification of populations. These findings offer new insights into the process of population dispersal and differentiation during the peopling of the Americas. Text Bering Strait PubMed Central (PMC) Bering Strait PLoS Genetics 3 11 e185 |
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Research Article Wang, Sijia Lewis, Cecil M Jakobsson, Mattias Ramachandran, Sohini Ray, Nicolas Bedoya, Gabriel Rojas, Winston Parra, Maria V Molina, Julio A Gallo, Carla Mazzotti, Guido Poletti, Giovanni Hill, Kim Hurtado, Ana M Labuda, Damian Klitz, William Barrantes, Ramiro Bortolini, Maria Cátira Salzano, Francisco M Petzl-Erler, Maria Luiza Tsuneto, Luiza T Llop, Elena Rothhammer, Francisco Excoffier, Laurent Feldman, Marcus W Rosenberg, Noah A Ruiz-Linares, Andrés Genetic Variation and Population Structure in Native Americans |
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Research Article |
description |
We examined genetic diversity and population structure in the American landmass using 678 autosomal microsatellite markers genotyped in 422 individuals representing 24 Native American populations sampled from North, Central, and South America. These data were analyzed jointly with similar data available in 54 other indigenous populations worldwide, including an additional five Native American groups. The Native American populations have lower genetic diversity and greater differentiation than populations from other continental regions. We observe gradients both of decreasing genetic diversity as a function of geographic distance from the Bering Strait and of decreasing genetic similarity to Siberians—signals of the southward dispersal of human populations from the northwestern tip of the Americas. We also observe evidence of: (1) a higher level of diversity and lower level of population structure in western South America compared to eastern South America, (2) a relative lack of differentiation between Mesoamerican and Andean populations, (3) a scenario in which coastal routes were easier for migrating peoples to traverse in comparison with inland routes, and (4) a partial agreement on a local scale between genetic similarity and the linguistic classification of populations. These findings offer new insights into the process of population dispersal and differentiation during the peopling of the Americas. |
format |
Text |
author |
Wang, Sijia Lewis, Cecil M Jakobsson, Mattias Ramachandran, Sohini Ray, Nicolas Bedoya, Gabriel Rojas, Winston Parra, Maria V Molina, Julio A Gallo, Carla Mazzotti, Guido Poletti, Giovanni Hill, Kim Hurtado, Ana M Labuda, Damian Klitz, William Barrantes, Ramiro Bortolini, Maria Cátira Salzano, Francisco M Petzl-Erler, Maria Luiza Tsuneto, Luiza T Llop, Elena Rothhammer, Francisco Excoffier, Laurent Feldman, Marcus W Rosenberg, Noah A Ruiz-Linares, Andrés |
author_facet |
Wang, Sijia Lewis, Cecil M Jakobsson, Mattias Ramachandran, Sohini Ray, Nicolas Bedoya, Gabriel Rojas, Winston Parra, Maria V Molina, Julio A Gallo, Carla Mazzotti, Guido Poletti, Giovanni Hill, Kim Hurtado, Ana M Labuda, Damian Klitz, William Barrantes, Ramiro Bortolini, Maria Cátira Salzano, Francisco M Petzl-Erler, Maria Luiza Tsuneto, Luiza T Llop, Elena Rothhammer, Francisco Excoffier, Laurent Feldman, Marcus W Rosenberg, Noah A Ruiz-Linares, Andrés |
author_sort |
Wang, Sijia |
title |
Genetic Variation and Population Structure in Native Americans |
title_short |
Genetic Variation and Population Structure in Native Americans |
title_full |
Genetic Variation and Population Structure in Native Americans |
title_fullStr |
Genetic Variation and Population Structure in Native Americans |
title_full_unstemmed |
Genetic Variation and Population Structure in Native Americans |
title_sort |
genetic variation and population structure in native americans |
publisher |
Public Library of Science |
publishDate |
2007 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2082466 http://www.ncbi.nlm.nih.gov/pubmed/18039031 https://doi.org/10.1371/journal.pgen.0030185 |
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Bering Strait |
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Bering Strait |
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Bering Strait |
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Bering Strait |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2082466 http://www.ncbi.nlm.nih.gov/pubmed/18039031 http://dx.doi.org/10.1371/journal.pgen.0030185 |
op_rights |
Copyright: © 2007 Wang et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1371/journal.pgen.0030185 |
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PLoS Genetics |
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3 |
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11 |
container_start_page |
e185 |
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1766378529928249344 |