A Single Residue Change in Vibrio harveyi Hemolysin Results in the Loss of Phospholipase and Hemolytic Activities and Pathogenicity for Turbot (Scophthalmus maximus)▿

Vibrio harveyi hemolysin, an important virulence determinant in fish pathogenesis, was further characterized, and the enzyme was identified as a phospholipase B by gas chromatography. Site-directed mutagenesis revealed that a specific residue, Ser153, was critical for its enzymatic activity and for...

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Published in:Journal of Bacteriology
Main Authors: Sun, Boguang, Zhang, Xiao-Hua, Tang, Xuexi, Wang, Shushan, Zhong, Yingbin, Chen, Jixiang, Austin, Brian
Format: Text
Language:English
Published: American Society for Microbiology 2007
Subjects:
Enzymes and Proteins
Scophthalmus maximus
Turbot
Online Access:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1899364
http://www.ncbi.nlm.nih.gov/pubmed/17220231
https://doi.org/10.1128/JB.01650-06
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spelling ftpubmed:oai:pubmedcentral.nih.gov:1899364 2023-05-15T18:15:41+02:00 A Single Residue Change in Vibrio harveyi Hemolysin Results in the Loss of Phospholipase and Hemolytic Activities and Pathogenicity for Turbot (Scophthalmus maximus)▿ Sun, Boguang Zhang, Xiao-Hua Tang, Xuexi Wang, Shushan Zhong, Yingbin Chen, Jixiang Austin, Brian 2007-03 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1899364 http://www.ncbi.nlm.nih.gov/pubmed/17220231 https://doi.org/10.1128/JB.01650-06 en eng American Society for Microbiology http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1899364 http://www.ncbi.nlm.nih.gov/pubmed/17220231 http://dx.doi.org/10.1128/JB.01650-06 Copyright © 2007, American Society for Microbiology Enzymes and Proteins Text 2007 ftpubmed https://doi.org/10.1128/JB.01650-06 2013-08-31T22:26:05Z Vibrio harveyi hemolysin, an important virulence determinant in fish pathogenesis, was further characterized, and the enzyme was identified as a phospholipase B by gas chromatography. Site-directed mutagenesis revealed that a specific residue, Ser153, was critical for its enzymatic activity and for its virulence in fish. Text Scophthalmus maximus Turbot PubMed Central (PMC) Journal of Bacteriology 189 6 2575 2579
institution Open Polar
collection PubMed Central (PMC)
op_collection_id ftpubmed
language English
topic Enzymes and Proteins
spellingShingle Enzymes and Proteins
Sun, Boguang
Zhang, Xiao-Hua
Tang, Xuexi
Wang, Shushan
Zhong, Yingbin
Chen, Jixiang
Austin, Brian
A Single Residue Change in Vibrio harveyi Hemolysin Results in the Loss of Phospholipase and Hemolytic Activities and Pathogenicity for Turbot (Scophthalmus maximus)▿
topic_facet Enzymes and Proteins
description Vibrio harveyi hemolysin, an important virulence determinant in fish pathogenesis, was further characterized, and the enzyme was identified as a phospholipase B by gas chromatography. Site-directed mutagenesis revealed that a specific residue, Ser153, was critical for its enzymatic activity and for its virulence in fish.
format Text
author Sun, Boguang
Zhang, Xiao-Hua
Tang, Xuexi
Wang, Shushan
Zhong, Yingbin
Chen, Jixiang
Austin, Brian
author_facet Sun, Boguang
Zhang, Xiao-Hua
Tang, Xuexi
Wang, Shushan
Zhong, Yingbin
Chen, Jixiang
Austin, Brian
author_sort Sun, Boguang
title A Single Residue Change in Vibrio harveyi Hemolysin Results in the Loss of Phospholipase and Hemolytic Activities and Pathogenicity for Turbot (Scophthalmus maximus)▿
title_short A Single Residue Change in Vibrio harveyi Hemolysin Results in the Loss of Phospholipase and Hemolytic Activities and Pathogenicity for Turbot (Scophthalmus maximus)▿
title_full A Single Residue Change in Vibrio harveyi Hemolysin Results in the Loss of Phospholipase and Hemolytic Activities and Pathogenicity for Turbot (Scophthalmus maximus)▿
title_fullStr A Single Residue Change in Vibrio harveyi Hemolysin Results in the Loss of Phospholipase and Hemolytic Activities and Pathogenicity for Turbot (Scophthalmus maximus)▿
title_full_unstemmed A Single Residue Change in Vibrio harveyi Hemolysin Results in the Loss of Phospholipase and Hemolytic Activities and Pathogenicity for Turbot (Scophthalmus maximus)▿
title_sort single residue change in vibrio harveyi hemolysin results in the loss of phospholipase and hemolytic activities and pathogenicity for turbot (scophthalmus maximus)▿
publisher American Society for Microbiology
publishDate 2007
url http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1899364
http://www.ncbi.nlm.nih.gov/pubmed/17220231
https://doi.org/10.1128/JB.01650-06
genre Scophthalmus maximus
Turbot
genre_facet Scophthalmus maximus
Turbot
op_relation http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1899364
http://www.ncbi.nlm.nih.gov/pubmed/17220231
http://dx.doi.org/10.1128/JB.01650-06
op_rights Copyright © 2007, American Society for Microbiology
op_doi https://doi.org/10.1128/JB.01650-06
container_title Journal of Bacteriology
container_volume 189
container_issue 6
container_start_page 2575
op_container_end_page 2579
_version_ 1766188875743494144

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