Detection and prevalence of pneumococci with increased resistance to penicillin.
Susceptibility to penicillin was determined for 6000 strains of pneumococci isolated during 1974--76 from patients in Alberta and the adjacent region of the Northwest Territories. Strains were considered to be relatively resistant if the minimum inhibitory concentration (MIC) of penicillin was 0.16...
Main Authors: | , , |
---|---|
Format: | Text |
Language: | English |
Published: |
1977
|
Subjects: | |
Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1880287 http://www.ncbi.nlm.nih.gov/pubmed/23894 |
id |
ftpubmed:oai:pubmedcentral.nih.gov:1880287 |
---|---|
record_format |
openpolar |
spelling |
ftpubmed:oai:pubmedcentral.nih.gov:1880287 2023-05-15T17:46:40+02:00 Detection and prevalence of pneumococci with increased resistance to penicillin. Dixon, J. M. Lipinski, A. E. Graham, M. E. 1977-11-19 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1880287 http://www.ncbi.nlm.nih.gov/pubmed/23894 en eng http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1880287 http://www.ncbi.nlm.nih.gov/pubmed/23894 Research Article Text 1977 ftpubmed 2013-08-31T21:31:03Z Susceptibility to penicillin was determined for 6000 strains of pneumococci isolated during 1974--76 from patients in Alberta and the adjacent region of the Northwest Territories. Strains were considered to be relatively resistant if the minimum inhibitory concentration (MIC) of penicillin was 0.16 microgram (0.26 U)/mL or more, which is eight or more times greater than the MIC for fully susceptible strains. Resistance was detected in 143 strains (2.4%) isolated from 122 patients and belonging to four capsular types. The MIC of the most resistant strains was 0.32 microgram (0.53 U/mL. Penicillin-resistant strains were highly resistant to oxacillin, the MIC being at least 30 times greater than that for penicillin-susceptible strains. Pneumococci resistant to penicillin may readily be detected by the narrowness or absence of a zone of inhibition around a 1-microgram oxacillin disc in susceptibility tests on blood agar. The degree of resistance reported here is relative and does not necessarily preclude successful treatment with full therapeutic doses of penicillin G, but penicillin preparations that give low blood concentrations may not be suitable for treating infections caused by these strains. Text Northwest Territories PubMed Central (PMC) Northwest Territories |
institution |
Open Polar |
collection |
PubMed Central (PMC) |
op_collection_id |
ftpubmed |
language |
English |
topic |
Research Article |
spellingShingle |
Research Article Dixon, J. M. Lipinski, A. E. Graham, M. E. Detection and prevalence of pneumococci with increased resistance to penicillin. |
topic_facet |
Research Article |
description |
Susceptibility to penicillin was determined for 6000 strains of pneumococci isolated during 1974--76 from patients in Alberta and the adjacent region of the Northwest Territories. Strains were considered to be relatively resistant if the minimum inhibitory concentration (MIC) of penicillin was 0.16 microgram (0.26 U)/mL or more, which is eight or more times greater than the MIC for fully susceptible strains. Resistance was detected in 143 strains (2.4%) isolated from 122 patients and belonging to four capsular types. The MIC of the most resistant strains was 0.32 microgram (0.53 U/mL. Penicillin-resistant strains were highly resistant to oxacillin, the MIC being at least 30 times greater than that for penicillin-susceptible strains. Pneumococci resistant to penicillin may readily be detected by the narrowness or absence of a zone of inhibition around a 1-microgram oxacillin disc in susceptibility tests on blood agar. The degree of resistance reported here is relative and does not necessarily preclude successful treatment with full therapeutic doses of penicillin G, but penicillin preparations that give low blood concentrations may not be suitable for treating infections caused by these strains. |
format |
Text |
author |
Dixon, J. M. Lipinski, A. E. Graham, M. E. |
author_facet |
Dixon, J. M. Lipinski, A. E. Graham, M. E. |
author_sort |
Dixon, J. M. |
title |
Detection and prevalence of pneumococci with increased resistance to penicillin. |
title_short |
Detection and prevalence of pneumococci with increased resistance to penicillin. |
title_full |
Detection and prevalence of pneumococci with increased resistance to penicillin. |
title_fullStr |
Detection and prevalence of pneumococci with increased resistance to penicillin. |
title_full_unstemmed |
Detection and prevalence of pneumococci with increased resistance to penicillin. |
title_sort |
detection and prevalence of pneumococci with increased resistance to penicillin. |
publishDate |
1977 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1880287 http://www.ncbi.nlm.nih.gov/pubmed/23894 |
geographic |
Northwest Territories |
geographic_facet |
Northwest Territories |
genre |
Northwest Territories |
genre_facet |
Northwest Territories |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1880287 http://www.ncbi.nlm.nih.gov/pubmed/23894 |
_version_ |
1766150460029272064 |