Were inefficient mitochondrial haplogroups selected during migrations of modern humans? A test using modular kinetic analysis of coupling in mitochondria from cybrid cell lines
We introduce a general test of the bioenergetic importance of mtDNA (mitochondrial DNA) variants: modular kinetic analysis of oxidative phosphorylation in mitochondria from cybrid cells with constant nuclear DNA but different mtDNA. We have applied this test to the hypothesis [Ruiz-Pesini, Mishmar,...
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Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1868799 http://www.ncbi.nlm.nih.gov/pubmed/17355224 https://doi.org/10.1042/BJ20061609 |
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ftpubmed:oai:pubmedcentral.nih.gov:1868799 2023-05-15T15:01:18+02:00 Were inefficient mitochondrial haplogroups selected during migrations of modern humans? A test using modular kinetic analysis of coupling in mitochondria from cybrid cell lines Amo, Taku Brand, Martin D. 2007-05-14 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1868799 http://www.ncbi.nlm.nih.gov/pubmed/17355224 https://doi.org/10.1042/BJ20061609 en eng Portland Press Ltd. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1868799 http://www.ncbi.nlm.nih.gov/pubmed/17355224 http://dx.doi.org/10.1042/BJ20061609 © 2007 Biochemical Society Research Article Text 2007 ftpubmed https://doi.org/10.1042/BJ20061609 2013-08-31T20:57:52Z We introduce a general test of the bioenergetic importance of mtDNA (mitochondrial DNA) variants: modular kinetic analysis of oxidative phosphorylation in mitochondria from cybrid cells with constant nuclear DNA but different mtDNA. We have applied this test to the hypothesis [Ruiz-Pesini, Mishmar, Brandon, Procaccio and Wallace (2004) Science 303, 223–226] that particular mtDNA haplogroups (specific combinations of polymorphisms) that cause lowered coupling efficiency, leading to generation of less ATP and more heat, were positively selected during radiations of modern humans into colder climates. Contrary to the predictions of this hypothesis, mitochondria from Arctic haplogroups had similar or even greater coupling efficiency than mitochondria from tropical haplogroups. Text Arctic PubMed Central (PMC) Arctic Biochemical Journal 404 2 345 351 |
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Research Article Amo, Taku Brand, Martin D. Were inefficient mitochondrial haplogroups selected during migrations of modern humans? A test using modular kinetic analysis of coupling in mitochondria from cybrid cell lines |
topic_facet |
Research Article |
description |
We introduce a general test of the bioenergetic importance of mtDNA (mitochondrial DNA) variants: modular kinetic analysis of oxidative phosphorylation in mitochondria from cybrid cells with constant nuclear DNA but different mtDNA. We have applied this test to the hypothesis [Ruiz-Pesini, Mishmar, Brandon, Procaccio and Wallace (2004) Science 303, 223–226] that particular mtDNA haplogroups (specific combinations of polymorphisms) that cause lowered coupling efficiency, leading to generation of less ATP and more heat, were positively selected during radiations of modern humans into colder climates. Contrary to the predictions of this hypothesis, mitochondria from Arctic haplogroups had similar or even greater coupling efficiency than mitochondria from tropical haplogroups. |
format |
Text |
author |
Amo, Taku Brand, Martin D. |
author_facet |
Amo, Taku Brand, Martin D. |
author_sort |
Amo, Taku |
title |
Were inefficient mitochondrial haplogroups selected during migrations of modern humans? A test using modular kinetic analysis of coupling in mitochondria from cybrid cell lines |
title_short |
Were inefficient mitochondrial haplogroups selected during migrations of modern humans? A test using modular kinetic analysis of coupling in mitochondria from cybrid cell lines |
title_full |
Were inefficient mitochondrial haplogroups selected during migrations of modern humans? A test using modular kinetic analysis of coupling in mitochondria from cybrid cell lines |
title_fullStr |
Were inefficient mitochondrial haplogroups selected during migrations of modern humans? A test using modular kinetic analysis of coupling in mitochondria from cybrid cell lines |
title_full_unstemmed |
Were inefficient mitochondrial haplogroups selected during migrations of modern humans? A test using modular kinetic analysis of coupling in mitochondria from cybrid cell lines |
title_sort |
were inefficient mitochondrial haplogroups selected during migrations of modern humans? a test using modular kinetic analysis of coupling in mitochondria from cybrid cell lines |
publisher |
Portland Press Ltd. |
publishDate |
2007 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1868799 http://www.ncbi.nlm.nih.gov/pubmed/17355224 https://doi.org/10.1042/BJ20061609 |
geographic |
Arctic |
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Arctic |
genre |
Arctic |
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Arctic |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1868799 http://www.ncbi.nlm.nih.gov/pubmed/17355224 http://dx.doi.org/10.1042/BJ20061609 |
op_rights |
© 2007 Biochemical Society |
op_doi |
https://doi.org/10.1042/BJ20061609 |
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Biochemical Journal |
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404 |
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2 |
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345 |
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351 |
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1766333330908774400 |