Disseminated tuberculoid lesions in infants following BCG vaccination.
The records of 830 consecutive autopsies at Children's Hospital, Winnipeg revealed that 26 of the 36 infants (34 Canadian Indian, 1 Inuit and 1 Caucasian) given BCG vaccine shortly after birth had tuberculoid granulomas in various sites, including the vaccination site, regional lymph nodes, liv...
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ftpubmed:oai:pubmedcentral.nih.gov:1862059 2023-05-15T16:55:04+02:00 Disseminated tuberculoid lesions in infants following BCG vaccination. Trevenen, C. L. Pagtakhan, R. D. 1982-09-15 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1862059 http://www.ncbi.nlm.nih.gov/pubmed/6749273 en eng http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1862059 http://www.ncbi.nlm.nih.gov/pubmed/6749273 Research Article Text 1982 ftpubmed 2013-08-31T20:36:59Z The records of 830 consecutive autopsies at Children's Hospital, Winnipeg revealed that 26 of the 36 infants (34 Canadian Indian, 1 Inuit and 1 Caucasian) given BCG vaccine shortly after birth had tuberculoid granulomas in various sites, including the vaccination site, regional lymph nodes, liver, spleen, lung, bone marrow and salivary gland. Mycobacterium bovis, BCG type, was identified in three of the four cases in which isolation was attempted. The principal causes of death had been sudden infant death syndrome and respiratory tract infections. None of the infants had histologic evidence of an immune deficiency. However, it is possible that in two cases the dissemination of BCG was enhanced by a temporary immunologic defect induced by malnutrition. Text inuit PubMed Central (PMC) Indian |
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Research Article Trevenen, C. L. Pagtakhan, R. D. Disseminated tuberculoid lesions in infants following BCG vaccination. |
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Research Article |
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The records of 830 consecutive autopsies at Children's Hospital, Winnipeg revealed that 26 of the 36 infants (34 Canadian Indian, 1 Inuit and 1 Caucasian) given BCG vaccine shortly after birth had tuberculoid granulomas in various sites, including the vaccination site, regional lymph nodes, liver, spleen, lung, bone marrow and salivary gland. Mycobacterium bovis, BCG type, was identified in three of the four cases in which isolation was attempted. The principal causes of death had been sudden infant death syndrome and respiratory tract infections. None of the infants had histologic evidence of an immune deficiency. However, it is possible that in two cases the dissemination of BCG was enhanced by a temporary immunologic defect induced by malnutrition. |
format |
Text |
author |
Trevenen, C. L. Pagtakhan, R. D. |
author_facet |
Trevenen, C. L. Pagtakhan, R. D. |
author_sort |
Trevenen, C. L. |
title |
Disseminated tuberculoid lesions in infants following BCG vaccination. |
title_short |
Disseminated tuberculoid lesions in infants following BCG vaccination. |
title_full |
Disseminated tuberculoid lesions in infants following BCG vaccination. |
title_fullStr |
Disseminated tuberculoid lesions in infants following BCG vaccination. |
title_full_unstemmed |
Disseminated tuberculoid lesions in infants following BCG vaccination. |
title_sort |
disseminated tuberculoid lesions in infants following bcg vaccination. |
publishDate |
1982 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1862059 http://www.ncbi.nlm.nih.gov/pubmed/6749273 |
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Indian |
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Indian |
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inuit |
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inuit |
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1862059 http://www.ncbi.nlm.nih.gov/pubmed/6749273 |
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