Ethnic variation of Fcγ receptor polymorphism in Sami and Norwegian populations

Receptors for the Fc domain of IgG (FcγR) play a critical role in linking cellular and humoral immunity. The various FcγR genotypes may contribute to differences in infectious and immune-related diseases in various ethnic populations. The Samis are the aboriginal inhabitants of Norway and Fennoscand...

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Published in:Immunology
Main Authors: Torkildsen, Øivind, Utsi, Egil, Mellgren, Svein Ivar, Harbo, Hanne F, Vedeler, Christian A, Myhr, Kjell-Morten
Format: Text
Language:English
Published: Blackwell Science Inc 2005
Subjects:
Online Access:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1782156
http://www.ncbi.nlm.nih.gov/pubmed/15946259
https://doi.org/10.1111/j.1365-2567.2005.02158.x
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spelling ftpubmed:oai:pubmedcentral.nih.gov:1782156 2023-05-15T18:10:43+02:00 Ethnic variation of Fcγ receptor polymorphism in Sami and Norwegian populations Torkildsen, Øivind Utsi, Egil Mellgren, Svein Ivar Harbo, Hanne F Vedeler, Christian A Myhr, Kjell-Morten 2005-07 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1782156 http://www.ncbi.nlm.nih.gov/pubmed/15946259 https://doi.org/10.1111/j.1365-2567.2005.02158.x en eng Blackwell Science Inc http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1782156 http://www.ncbi.nlm.nih.gov/pubmed/15946259 http://dx.doi.org/10.1111/j.1365-2567.2005.02158.x © 2005 Blackwell Publishing Ltd Original Articles Text 2005 ftpubmed https://doi.org/10.1111/j.1365-2567.2005.02158.x 2013-08-31T16:53:17Z Receptors for the Fc domain of IgG (FcγR) play a critical role in linking cellular and humoral immunity. The various FcγR genotypes may contribute to differences in infectious and immune-related diseases in various ethnic populations. The Samis are the aboriginal inhabitants of Norway and Fennoscandinavia and differ ethnically from the Norwegians. The distribution of various immune-related diseases has been reported to differ between Sami and Norwegians. This is the first study to evaluate the distribution of FcγR polymorphisms in a Sami population. Two hundred Samis were genotyped for polymorphisms in the FcγRIIA, FcγRIIIA and FcγRIIIB genes. The genotype and allele frequencies were compared with those of 272 healthy Norwegians. The Sami and Norwegian FcγRIIA, FcγRIIIA and FcγRIIIB genotypes differed significantly. The Samis had higher frequencies of the FcγRIIa-H/H131, FcγRIIIa-F/F158 and FcγRIIIb-NA1/NA1 genotypes. The FcγR genotypes were non-randomly distributed in both populations. These findings may be important for the prevalence of autoimmune and infectious diseases in the two populations. Text sami PubMed Central (PMC) Norway Immunology 115 3 416 421
institution Open Polar
collection PubMed Central (PMC)
op_collection_id ftpubmed
language English
topic Original Articles
spellingShingle Original Articles
Torkildsen, Øivind
Utsi, Egil
Mellgren, Svein Ivar
Harbo, Hanne F
Vedeler, Christian A
Myhr, Kjell-Morten
Ethnic variation of Fcγ receptor polymorphism in Sami and Norwegian populations
topic_facet Original Articles
description Receptors for the Fc domain of IgG (FcγR) play a critical role in linking cellular and humoral immunity. The various FcγR genotypes may contribute to differences in infectious and immune-related diseases in various ethnic populations. The Samis are the aboriginal inhabitants of Norway and Fennoscandinavia and differ ethnically from the Norwegians. The distribution of various immune-related diseases has been reported to differ between Sami and Norwegians. This is the first study to evaluate the distribution of FcγR polymorphisms in a Sami population. Two hundred Samis were genotyped for polymorphisms in the FcγRIIA, FcγRIIIA and FcγRIIIB genes. The genotype and allele frequencies were compared with those of 272 healthy Norwegians. The Sami and Norwegian FcγRIIA, FcγRIIIA and FcγRIIIB genotypes differed significantly. The Samis had higher frequencies of the FcγRIIa-H/H131, FcγRIIIa-F/F158 and FcγRIIIb-NA1/NA1 genotypes. The FcγR genotypes were non-randomly distributed in both populations. These findings may be important for the prevalence of autoimmune and infectious diseases in the two populations.
format Text
author Torkildsen, Øivind
Utsi, Egil
Mellgren, Svein Ivar
Harbo, Hanne F
Vedeler, Christian A
Myhr, Kjell-Morten
author_facet Torkildsen, Øivind
Utsi, Egil
Mellgren, Svein Ivar
Harbo, Hanne F
Vedeler, Christian A
Myhr, Kjell-Morten
author_sort Torkildsen, Øivind
title Ethnic variation of Fcγ receptor polymorphism in Sami and Norwegian populations
title_short Ethnic variation of Fcγ receptor polymorphism in Sami and Norwegian populations
title_full Ethnic variation of Fcγ receptor polymorphism in Sami and Norwegian populations
title_fullStr Ethnic variation of Fcγ receptor polymorphism in Sami and Norwegian populations
title_full_unstemmed Ethnic variation of Fcγ receptor polymorphism in Sami and Norwegian populations
title_sort ethnic variation of fcγ receptor polymorphism in sami and norwegian populations
publisher Blackwell Science Inc
publishDate 2005
url http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1782156
http://www.ncbi.nlm.nih.gov/pubmed/15946259
https://doi.org/10.1111/j.1365-2567.2005.02158.x
geographic Norway
geographic_facet Norway
genre sami
genre_facet sami
op_relation http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1782156
http://www.ncbi.nlm.nih.gov/pubmed/15946259
http://dx.doi.org/10.1111/j.1365-2567.2005.02158.x
op_rights © 2005 Blackwell Publishing Ltd
op_doi https://doi.org/10.1111/j.1365-2567.2005.02158.x
container_title Immunology
container_volume 115
container_issue 3
container_start_page 416
op_container_end_page 421
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