Variants of the group-specific component system as demonstrated by immunofixation electrophoresis. Report of a new variant, Gc Boston (Ge B).

• Main Authors: Johnson, A M, Cleve, H, Alper, C
• Format: Text
• Language: English
• Published: 1975
• Subjects: Research Article; Norway; eskimo*
• Online Access: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1762900; http://www.ncbi.nlm.nih.gov/pubmed/1239191

Immunofixation electrophoresis is a relatively simple and reliable method for the genetic phenotyping of the group-specific component (Gc) of serum. This method permits direct comparison of electrophoretic mobilities and band concentrations, with no interference by other proteins. The variants Gc Ab and Gc Y appear identical by this technique; the Eskimo variant appears to be similar to Gc D but not to Gc Ab as previously reported. Gc Norway, also designated Gc 1C, is electrophoretically cathodal to the slower band of Gc 1 and therefore appears to be a distinct variant. A new variant, Gc Boston, is single banded with mobility between the two bands of Gc 1.