Genetic studies of low-abundance human plasma proteins. XIII. Population genetics of C1R complement subcomponent and description of new variants.
Isoelectric focusing and immunoblotting reveals considerable biochemical and genetic variation in the C1R subcomponent of the first complement component. The nature of the intraindividual biochemical variation can be explained by differences in sialic acid content because after digestion with neuram...
Main Authors: | , , |
---|---|
Format: | Text |
Language: | English |
Published: |
1989
|
Subjects: | |
Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1715479 http://www.ncbi.nlm.nih.gov/pubmed/2535773 |
id |
ftpubmed:oai:pubmedcentral.nih.gov:1715479 |
---|---|
record_format |
openpolar |
spelling |
ftpubmed:oai:pubmedcentral.nih.gov:1715479 2023-05-15T13:14:31+02:00 Genetic studies of low-abundance human plasma proteins. XIII. Population genetics of C1R complement subcomponent and description of new variants. Kamboh, M I Lyons, L A Ferrell, R E 1989-01 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1715479 http://www.ncbi.nlm.nih.gov/pubmed/2535773 en eng http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1715479 http://www.ncbi.nlm.nih.gov/pubmed/2535773 Research Article Text 1989 ftpubmed 2013-08-31T13:42:29Z Isoelectric focusing and immunoblotting reveals considerable biochemical and genetic variation in the C1R subcomponent of the first complement component. The nature of the intraindividual biochemical variation can be explained by differences in sialic acid content because after digestion with neuraminidase the terminal sialic acids are removed to yield a single major band corresponding to the C1R polypeptide. Plasma samples from a large number of different ethnic groups, consisting of U.S. whites, U.S. blacks, Nigerian blacks, and Inuit, Aleut, and Amerindian populations from the Western Hemisphere have revealed genetically determined charge variation with heterozygous phenotypes consisting of two major asialo bands, indicating that the underlying variation is not due to variation in sialic acid content. Two previously reported common alleles, C1R*1 and CIR*2, have been observed in all studied populations, the notable exception being the Dogrib Indian population, which is devoid of the C1R*2 allele. Several new alleles--designated C1R*3, C1R*4, C1R*5, C1R*6, and C1R*7-have been observed, with variable frequencies ranging from the occurrence in a single individual and related family members to the polymorphic occurrence of certain alleles in several populations. Of these new alleles, the C1R*5 is of considerable interest in population and anthropological genetics studies. The C1R*5 allele is widely distributed, at a frequency of .03 to .17, in all of the North American aboriginal populations screened. This allele is not present in U.S. whites but is present at a polymorphic frequency in U.S. and Nigerian blacks.(ABSTRACT TRUNCATED AT 250 WORDS) Text aleut Dogrib inuit PubMed Central (PMC) Indian |
institution |
Open Polar |
collection |
PubMed Central (PMC) |
op_collection_id |
ftpubmed |
language |
English |
topic |
Research Article |
spellingShingle |
Research Article Kamboh, M I Lyons, L A Ferrell, R E Genetic studies of low-abundance human plasma proteins. XIII. Population genetics of C1R complement subcomponent and description of new variants. |
topic_facet |
Research Article |
description |
Isoelectric focusing and immunoblotting reveals considerable biochemical and genetic variation in the C1R subcomponent of the first complement component. The nature of the intraindividual biochemical variation can be explained by differences in sialic acid content because after digestion with neuraminidase the terminal sialic acids are removed to yield a single major band corresponding to the C1R polypeptide. Plasma samples from a large number of different ethnic groups, consisting of U.S. whites, U.S. blacks, Nigerian blacks, and Inuit, Aleut, and Amerindian populations from the Western Hemisphere have revealed genetically determined charge variation with heterozygous phenotypes consisting of two major asialo bands, indicating that the underlying variation is not due to variation in sialic acid content. Two previously reported common alleles, C1R*1 and CIR*2, have been observed in all studied populations, the notable exception being the Dogrib Indian population, which is devoid of the C1R*2 allele. Several new alleles--designated C1R*3, C1R*4, C1R*5, C1R*6, and C1R*7-have been observed, with variable frequencies ranging from the occurrence in a single individual and related family members to the polymorphic occurrence of certain alleles in several populations. Of these new alleles, the C1R*5 is of considerable interest in population and anthropological genetics studies. The C1R*5 allele is widely distributed, at a frequency of .03 to .17, in all of the North American aboriginal populations screened. This allele is not present in U.S. whites but is present at a polymorphic frequency in U.S. and Nigerian blacks.(ABSTRACT TRUNCATED AT 250 WORDS) |
format |
Text |
author |
Kamboh, M I Lyons, L A Ferrell, R E |
author_facet |
Kamboh, M I Lyons, L A Ferrell, R E |
author_sort |
Kamboh, M I |
title |
Genetic studies of low-abundance human plasma proteins. XIII. Population genetics of C1R complement subcomponent and description of new variants. |
title_short |
Genetic studies of low-abundance human plasma proteins. XIII. Population genetics of C1R complement subcomponent and description of new variants. |
title_full |
Genetic studies of low-abundance human plasma proteins. XIII. Population genetics of C1R complement subcomponent and description of new variants. |
title_fullStr |
Genetic studies of low-abundance human plasma proteins. XIII. Population genetics of C1R complement subcomponent and description of new variants. |
title_full_unstemmed |
Genetic studies of low-abundance human plasma proteins. XIII. Population genetics of C1R complement subcomponent and description of new variants. |
title_sort |
genetic studies of low-abundance human plasma proteins. xiii. population genetics of c1r complement subcomponent and description of new variants. |
publishDate |
1989 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1715479 http://www.ncbi.nlm.nih.gov/pubmed/2535773 |
geographic |
Indian |
geographic_facet |
Indian |
genre |
aleut Dogrib inuit |
genre_facet |
aleut Dogrib inuit |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1715479 http://www.ncbi.nlm.nih.gov/pubmed/2535773 |
_version_ |
1766264029224894464 |