Toxicity and mutagenicity of 2,4,-6-trinitrotoluene and its microbial metabolites.

TNT (2,4,6-trinitrotoluene) of explosive grade is highly toxic to marine forms that included fresh water unicellular green algae (Selenastrum capricornutum), tidepool copepods (Tigriopus californicus), and oyster larvae (Crassostrea gigas), and mutagenic to Salmonella typhimurium. On the basis of mu...

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Bibliographic Details
Main Authors: Won, W D, DiSalvo, L H, Ng, J
Format: Text
Language:English
Published: 1976
Subjects:
Research Article
Crassostrea gigas
Copepods
Online Access:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC169821
http://www.ncbi.nlm.nih.gov/pubmed/773306
id ftpubmed:oai:pubmedcentral.nih.gov:169821
record_format openpolar
spelling ftpubmed:oai:pubmedcentral.nih.gov:169821 2023-05-15T15:58:05+02:00 Toxicity and mutagenicity of 2,4,-6-trinitrotoluene and its microbial metabolites. Won, W D DiSalvo, L H Ng, J 1976-04 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC169821 http://www.ncbi.nlm.nih.gov/pubmed/773306 en eng http://www.ncbi.nlm.nih.gov/pmc/articles/PMC169821 http://www.ncbi.nlm.nih.gov/pubmed/773306 Research Article Text 1976 ftpubmed 2013-08-29T12:45:05Z TNT (2,4,6-trinitrotoluene) of explosive grade is highly toxic to marine forms that included fresh water unicellular green algae (Selenastrum capricornutum), tidepool copepods (Tigriopus californicus), and oyster larvae (Crassostrea gigas), and mutagenic to Salmonella typhimurium. On the basis of mutagenic assays carried out with a set of histidine-requiring strains of the bacterium, TNT was detected as a frameshift mutagen that significantly accelerates the reversion rate of a frameshift tester, TA-98. In contrast, the major microbial metabolites of TNT appeared to be nontoxic and nonmutagenic. Text Crassostrea gigas Copepods PubMed Central (PMC)
institution Open Polar
collection PubMed Central (PMC)
op_collection_id ftpubmed
language English
topic Research Article
spellingShingle Research Article
Won, W D
DiSalvo, L H
Ng, J
Toxicity and mutagenicity of 2,4,-6-trinitrotoluene and its microbial metabolites.
topic_facet Research Article
description TNT (2,4,6-trinitrotoluene) of explosive grade is highly toxic to marine forms that included fresh water unicellular green algae (Selenastrum capricornutum), tidepool copepods (Tigriopus californicus), and oyster larvae (Crassostrea gigas), and mutagenic to Salmonella typhimurium. On the basis of mutagenic assays carried out with a set of histidine-requiring strains of the bacterium, TNT was detected as a frameshift mutagen that significantly accelerates the reversion rate of a frameshift tester, TA-98. In contrast, the major microbial metabolites of TNT appeared to be nontoxic and nonmutagenic.
format Text
author Won, W D
DiSalvo, L H
Ng, J
author_facet Won, W D
DiSalvo, L H
Ng, J
author_sort Won, W D
title Toxicity and mutagenicity of 2,4,-6-trinitrotoluene and its microbial metabolites.
title_short Toxicity and mutagenicity of 2,4,-6-trinitrotoluene and its microbial metabolites.
title_full Toxicity and mutagenicity of 2,4,-6-trinitrotoluene and its microbial metabolites.
title_fullStr Toxicity and mutagenicity of 2,4,-6-trinitrotoluene and its microbial metabolites.
title_full_unstemmed Toxicity and mutagenicity of 2,4,-6-trinitrotoluene and its microbial metabolites.
title_sort toxicity and mutagenicity of 2,4,-6-trinitrotoluene and its microbial metabolites.
publishDate 1976
url http://www.ncbi.nlm.nih.gov/pmc/articles/PMC169821
http://www.ncbi.nlm.nih.gov/pubmed/773306
genre Crassostrea gigas
Copepods
genre_facet Crassostrea gigas
Copepods
op_relation http://www.ncbi.nlm.nih.gov/pmc/articles/PMC169821
http://www.ncbi.nlm.nih.gov/pubmed/773306
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