Genetic studies of low-abundance human plasma proteins. V. Evidence for a second orosomucoid structural locus (ORM2) expressed in plasma.
Orosomucoid (ORM) or alpha-1-acid glycoprotein is an acute-phase protein of human plasma whose function is suggested to be the competitive inhibition of cellular recognition by infective agents. Genetically determined variation in ORM has been reported, with two major alleles segregating in all popu...
Main Authors: | , , |
---|---|
Format: | Text |
Language: | English |
Published: |
1987
|
Subjects: | |
Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1684184 http://www.ncbi.nlm.nih.gov/pubmed/3631077 |
id |
ftpubmed:oai:pubmedcentral.nih.gov:1684184 |
---|---|
record_format |
openpolar |
spelling |
ftpubmed:oai:pubmedcentral.nih.gov:1684184 2023-05-15T16:07:13+02:00 Genetic studies of low-abundance human plasma proteins. V. Evidence for a second orosomucoid structural locus (ORM2) expressed in plasma. Escallon, M H Ferrell, R E Kamboh, M I 1987-09 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1684184 http://www.ncbi.nlm.nih.gov/pubmed/3631077 en eng http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1684184 http://www.ncbi.nlm.nih.gov/pubmed/3631077 Research Article Text 1987 ftpubmed 2013-08-31T12:14:47Z Orosomucoid (ORM) or alpha-1-acid glycoprotein is an acute-phase protein of human plasma whose function is suggested to be the competitive inhibition of cellular recognition by infective agents. Genetically determined variation in ORM has been reported, with two major alleles segregating in all populations studied to date. Isoelectric focusing-immunoblotting studies of ORM revealed the presence of isoprotein species that did not segregate with the predominant alleles at the ORM locus and suggested the expression of a second structural gene locus for orosomucoid (ORM2). Genetically independent variation consistent with expression of the ORM2 locus was observed in plasma samples from American blacks but was not observed in U.S. whites or sampled populations of North- and South-American Indians, Eskimos, Aleuts, or New Guinea Highlanders. The population allele frequencies for this locus were .958, .025, .006, and .011 for alleles ORM*1, ORM2*2, ORM2*3, and ORM2*4, respectively. Family studies confirm the autosomal codominant inheritance of the observed phenotypes. Text eskimo* PubMed Central (PMC) |
institution |
Open Polar |
collection |
PubMed Central (PMC) |
op_collection_id |
ftpubmed |
language |
English |
topic |
Research Article |
spellingShingle |
Research Article Escallon, M H Ferrell, R E Kamboh, M I Genetic studies of low-abundance human plasma proteins. V. Evidence for a second orosomucoid structural locus (ORM2) expressed in plasma. |
topic_facet |
Research Article |
description |
Orosomucoid (ORM) or alpha-1-acid glycoprotein is an acute-phase protein of human plasma whose function is suggested to be the competitive inhibition of cellular recognition by infective agents. Genetically determined variation in ORM has been reported, with two major alleles segregating in all populations studied to date. Isoelectric focusing-immunoblotting studies of ORM revealed the presence of isoprotein species that did not segregate with the predominant alleles at the ORM locus and suggested the expression of a second structural gene locus for orosomucoid (ORM2). Genetically independent variation consistent with expression of the ORM2 locus was observed in plasma samples from American blacks but was not observed in U.S. whites or sampled populations of North- and South-American Indians, Eskimos, Aleuts, or New Guinea Highlanders. The population allele frequencies for this locus were .958, .025, .006, and .011 for alleles ORM*1, ORM2*2, ORM2*3, and ORM2*4, respectively. Family studies confirm the autosomal codominant inheritance of the observed phenotypes. |
format |
Text |
author |
Escallon, M H Ferrell, R E Kamboh, M I |
author_facet |
Escallon, M H Ferrell, R E Kamboh, M I |
author_sort |
Escallon, M H |
title |
Genetic studies of low-abundance human plasma proteins. V. Evidence for a second orosomucoid structural locus (ORM2) expressed in plasma. |
title_short |
Genetic studies of low-abundance human plasma proteins. V. Evidence for a second orosomucoid structural locus (ORM2) expressed in plasma. |
title_full |
Genetic studies of low-abundance human plasma proteins. V. Evidence for a second orosomucoid structural locus (ORM2) expressed in plasma. |
title_fullStr |
Genetic studies of low-abundance human plasma proteins. V. Evidence for a second orosomucoid structural locus (ORM2) expressed in plasma. |
title_full_unstemmed |
Genetic studies of low-abundance human plasma proteins. V. Evidence for a second orosomucoid structural locus (ORM2) expressed in plasma. |
title_sort |
genetic studies of low-abundance human plasma proteins. v. evidence for a second orosomucoid structural locus (orm2) expressed in plasma. |
publishDate |
1987 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1684184 http://www.ncbi.nlm.nih.gov/pubmed/3631077 |
genre |
eskimo* |
genre_facet |
eskimo* |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1684184 http://www.ncbi.nlm.nih.gov/pubmed/3631077 |
_version_ |
1766403280183754752 |