Absence of the Asian-specific region V mitochondrial marker in Native Beringians.
The Asian-specific 9-bp deletion between the genes for mitochondrial cytochrome oxidase II and lysine transfer RNA has been used to trace aboriginal human movements out of Southeast Asia and into portions of the South Pacific. Although it has been used to estimate the number of independent lineages...
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ftpubmed:oai:pubmedcentral.nih.gov:1682655 2023-05-15T15:54:36+02:00 Absence of the Asian-specific region V mitochondrial marker in Native Beringians. Shields, G F Hecker, K Voevoda, M I Reed, J K 1992-04 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1682655 http://www.ncbi.nlm.nih.gov/pubmed/1550120 en eng http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1682655 http://www.ncbi.nlm.nih.gov/pubmed/1550120 Research Article Text 1992 ftpubmed 2013-08-31T12:10:26Z The Asian-specific 9-bp deletion between the genes for mitochondrial cytochrome oxidase II and lysine transfer RNA has been used to trace aboriginal human movements out of Southeast Asia and into portions of the South Pacific. Although it has been used to estimate the number of independent lineages that occur in the New World, it has not been studied in native peoples of the Beringian region. Thus, we have used PCR to amplify and compare the lengths of DNA segments surrounding this deletion in native peoples of Beringia and the adjacent regions, as well as natives of the Altai Mountains of Southwestern Siberia. Of the 176 individuals analyzed here, the deletion was found in only 3 of 25 individuals from the Ust-Kan region of the Altai Mountains. We comment on the distribution of this marker and on potential relationships between Beringians and other Native American groups in which this marker has been surveyed. One Chukchi possessed three copies of the 9-bp sequence, which suggests (1) that the number of copies of this sequence in humans may be more variable than had been believed and (2) that a mechanism of replication based on tandem duplication may be a potential explanation for the origin of this length mutation in humans. Text Chukchi Beringia Siberia PubMed Central (PMC) Pacific |
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Research Article Shields, G F Hecker, K Voevoda, M I Reed, J K Absence of the Asian-specific region V mitochondrial marker in Native Beringians. |
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Research Article |
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The Asian-specific 9-bp deletion between the genes for mitochondrial cytochrome oxidase II and lysine transfer RNA has been used to trace aboriginal human movements out of Southeast Asia and into portions of the South Pacific. Although it has been used to estimate the number of independent lineages that occur in the New World, it has not been studied in native peoples of the Beringian region. Thus, we have used PCR to amplify and compare the lengths of DNA segments surrounding this deletion in native peoples of Beringia and the adjacent regions, as well as natives of the Altai Mountains of Southwestern Siberia. Of the 176 individuals analyzed here, the deletion was found in only 3 of 25 individuals from the Ust-Kan region of the Altai Mountains. We comment on the distribution of this marker and on potential relationships between Beringians and other Native American groups in which this marker has been surveyed. One Chukchi possessed three copies of the 9-bp sequence, which suggests (1) that the number of copies of this sequence in humans may be more variable than had been believed and (2) that a mechanism of replication based on tandem duplication may be a potential explanation for the origin of this length mutation in humans. |
format |
Text |
author |
Shields, G F Hecker, K Voevoda, M I Reed, J K |
author_facet |
Shields, G F Hecker, K Voevoda, M I Reed, J K |
author_sort |
Shields, G F |
title |
Absence of the Asian-specific region V mitochondrial marker in Native Beringians. |
title_short |
Absence of the Asian-specific region V mitochondrial marker in Native Beringians. |
title_full |
Absence of the Asian-specific region V mitochondrial marker in Native Beringians. |
title_fullStr |
Absence of the Asian-specific region V mitochondrial marker in Native Beringians. |
title_full_unstemmed |
Absence of the Asian-specific region V mitochondrial marker in Native Beringians. |
title_sort |
absence of the asian-specific region v mitochondrial marker in native beringians. |
publishDate |
1992 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1682655 http://www.ncbi.nlm.nih.gov/pubmed/1550120 |
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Pacific |
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Pacific |
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Chukchi Beringia Siberia |
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Chukchi Beringia Siberia |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1682655 http://www.ncbi.nlm.nih.gov/pubmed/1550120 |
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1766389842606817280 |