In vitro susceptibility of Helicobacter pylori to protolichesterinic acid from the lichen Cetraria islandica.

With reference to the traditional use of Cetraria islandica (Iceland moss) for relief of gastric and duodenal ulcer, plant extracts were screened for in vitro activity against Helicobacter pylori. (+)-Protolichesterinic acid, an aliphatic alpha-methylene-gamma-lactone, was identified as an active co...

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Bibliographic Details
Main Authors: Ingolfsdottir, K, Hjalmarsdottir, M A, Sigurdsson, A, Gudjonsdottir, G A, Brynjolfsdottir, A, Steingrimsson, O
Format: Text
Language:English
Published: 1997
Subjects:
Research Article
Iceland
Online Access:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC163690
http://www.ncbi.nlm.nih.gov/pubmed/8980785
Description
Summary:With reference to the traditional use of Cetraria islandica (Iceland moss) for relief of gastric and duodenal ulcer, plant extracts were screened for in vitro activity against Helicobacter pylori. (+)-Protolichesterinic acid, an aliphatic alpha-methylene-gamma-lactone, was identified as an active component. The MIC range of protolichesterinic acid, in free as well as salt form, was 16 to 64 micrograms/ml.

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