Isolation and pharmacological characterization of a phospholipase A2 myotoxin from the venom of the Irian Jayan death adder (Acanthophis rugosus)

• Published in: British Journal of Pharmacology
• Main Authors: Wickramaratna, Janith C, Fry, Bryan G, Aguilar, Marie-Isabel, Kini, R Manjunatha, Hodgson, Wayne C
• Format: Text
• Language: English
• Published: 2003
• Subjects: Papers; Jaya; Antarc*; antarcticus
• Online Access: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1573671; http://www.ncbi.nlm.nih.gov/pubmed/12540524; https://doi.org/10.1038/sj.bjp.0705046

It has long been thought that death adder venoms are devoid of myotoxic activity based on studies done on Acanthophis antarcticus (Common death adder) venom. However, a recent clinical study reported rhabdomyolysis in patients following death adder envenomations, in Papua New Guinea, by a species th...