A segmental pattern of alkaline phosphatase activity within the notochord coincides with the initial formation of the vertebral bodies
This study shows that segmental expression of alkaline phosphatase (ALP) activity by the notochord of the Atlantic salmon (Salmo salar L.) coincides with the initial mineralization of the vertebral body (chordacentrum), and precedes ALP expression by presumed somite-derived cells external to the not...
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2005
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ftpubmed:oai:pubmedcentral.nih.gov:1571508 2023-05-15T15:32:08+02:00 A segmental pattern of alkaline phosphatase activity within the notochord coincides with the initial formation of the vertebral bodies Sindre, Grotmol Kari, Nordvik Harald, Kryvi Geir, K Totland 2005-05 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1571508 http://www.ncbi.nlm.nih.gov/pubmed/15857363 https://doi.org/10.1111/j.1469-7580.2005.00408.x en eng Blackwell Science Inc http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1571508 http://www.ncbi.nlm.nih.gov/pubmed/15857363 http://dx.doi.org/10.1111/j.1469-7580.2005.00408.x © Anatomical Society of Great Britain and Ireland 2005 Original Articles Text 2005 ftpubmed https://doi.org/10.1111/j.1469-7580.2005.00408.x 2013-08-31T06:54:48Z This study shows that segmental expression of alkaline phosphatase (ALP) activity by the notochord of the Atlantic salmon (Salmo salar L.) coincides with the initial mineralization of the vertebral body (chordacentrum), and precedes ALP expression by presumed somite-derived cells external to the notochordal sheath. The early expression of ALP indicates that the notochord plays an instructive role in the segmental patterning of the vertebral column. The chordacentra form segmentally as mineralized rings within the notochordal sheath, and ALP activity spreads within the chordoblast layer from ventral to dorsal, displaying the same progression and spatial distribution as the mineralization process. No ALP activity was observed in sclerotomal mesenchyme surrounding the notochordal sheath during initial formation of the chordacentra. Our results support previous findings indicating that the chordoblasts initiate a segmental differentiation of the notochordal sheath into chordacentra and intervertebral regions. Text Atlantic salmon Salmo salar PubMed Central (PMC) Journal of Anatomy 206 5 427 436 |
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Original Articles |
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Original Articles Sindre, Grotmol Kari, Nordvik Harald, Kryvi Geir, K Totland A segmental pattern of alkaline phosphatase activity within the notochord coincides with the initial formation of the vertebral bodies |
topic_facet |
Original Articles |
description |
This study shows that segmental expression of alkaline phosphatase (ALP) activity by the notochord of the Atlantic salmon (Salmo salar L.) coincides with the initial mineralization of the vertebral body (chordacentrum), and precedes ALP expression by presumed somite-derived cells external to the notochordal sheath. The early expression of ALP indicates that the notochord plays an instructive role in the segmental patterning of the vertebral column. The chordacentra form segmentally as mineralized rings within the notochordal sheath, and ALP activity spreads within the chordoblast layer from ventral to dorsal, displaying the same progression and spatial distribution as the mineralization process. No ALP activity was observed in sclerotomal mesenchyme surrounding the notochordal sheath during initial formation of the chordacentra. Our results support previous findings indicating that the chordoblasts initiate a segmental differentiation of the notochordal sheath into chordacentra and intervertebral regions. |
format |
Text |
author |
Sindre, Grotmol Kari, Nordvik Harald, Kryvi Geir, K Totland |
author_facet |
Sindre, Grotmol Kari, Nordvik Harald, Kryvi Geir, K Totland |
author_sort |
Sindre, Grotmol |
title |
A segmental pattern of alkaline phosphatase activity within the notochord coincides with the initial formation of the vertebral bodies |
title_short |
A segmental pattern of alkaline phosphatase activity within the notochord coincides with the initial formation of the vertebral bodies |
title_full |
A segmental pattern of alkaline phosphatase activity within the notochord coincides with the initial formation of the vertebral bodies |
title_fullStr |
A segmental pattern of alkaline phosphatase activity within the notochord coincides with the initial formation of the vertebral bodies |
title_full_unstemmed |
A segmental pattern of alkaline phosphatase activity within the notochord coincides with the initial formation of the vertebral bodies |
title_sort |
segmental pattern of alkaline phosphatase activity within the notochord coincides with the initial formation of the vertebral bodies |
publisher |
Blackwell Science Inc |
publishDate |
2005 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1571508 http://www.ncbi.nlm.nih.gov/pubmed/15857363 https://doi.org/10.1111/j.1469-7580.2005.00408.x |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1571508 http://www.ncbi.nlm.nih.gov/pubmed/15857363 http://dx.doi.org/10.1111/j.1469-7580.2005.00408.x |
op_rights |
© Anatomical Society of Great Britain and Ireland 2005 |
op_doi |
https://doi.org/10.1111/j.1469-7580.2005.00408.x |
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Journal of Anatomy |
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206 |
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5 |
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427 |
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436 |
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1766362638100463616 |