Immunohistochemical localization of BDNF-, TrkB- and TrkA-like proteins in the teleost lateral line system
The lateral line system, formed of both superficial (pit organs) and canal neuromasts, is one of the major mechanosensory systems in fish. It has always been assumed that this system depends on neurotrophins and their cognate Trk receptors for development and maintenance, as has been shown in other...
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ftpubmed:oai:pubmedcentral.nih.gov:1570709 2023-05-15T18:09:55+02:00 Immunohistochemical localization of BDNF-, TrkB- and TrkA-like proteins in the teleost lateral line system Germana, A Catania, S Cavallaro, M González-Martínez, T Ciriaco, E Hannestad, J Vega, JA 2002-05 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1570709 http://www.ncbi.nlm.nih.gov/pubmed/12090394 https://doi.org/10.1046/j.1469-7580.2002.00055.x en eng Blackwell Science Inc http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1570709 http://www.ncbi.nlm.nih.gov/pubmed/12090394 http://dx.doi.org/10.1046/j.1469-7580.2002.00055.x © Anatomical Society of Great Britain and Ireland 2002 Original Articles Text 2002 ftpubmed https://doi.org/10.1046/j.1469-7580.2002.00055.x 2013-08-31T06:52:21Z The lateral line system, formed of both superficial (pit organs) and canal neuromasts, is one of the major mechanosensory systems in fish. It has always been assumed that this system depends on neurotrophins and their cognate Trk receptors for development and maintenance, as has been shown in other mechanosensitive systems of vertebrates. However, until now this issue has not been specifically addressed. In this study we used immunohistochemistry to investigate the occurrence and localization both of neurotrophins (NGF-, BDNF- and NT-3-like) and of Trk-like proteins (TrkA-, TrkB-, TrkC-like) in alevins of Salmo salar and S. trutta. All cells in the pit organs of S. salar displayed strong immunoreactivity for TrkB-like and BDNF-like, whereas they were restricted to the hair cells in S. trutta. The hair, supporting and mantle cells of S. salar, and the mantle cells of S. trutta, also expressed TrkA-like immunoreactivity. In the canal neuromasts BDNF-, TrkA- and TrkB-like proteins were present in all cells, without differences between species. NGF-, NT-3- and TrkC-like immunoreactivity were never detected. The present results suggest that mechanoreceptive hair cells, as well as supporting cells, in the lateral line system are under the control of the BDNF–TrkB-like complex, and probably of ligands of TrkA-like receptors. Text Salmo salar PubMed Central (PMC) Journal of Anatomy 200 5 477 485 |
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Original Articles Germana, A Catania, S Cavallaro, M González-Martínez, T Ciriaco, E Hannestad, J Vega, JA Immunohistochemical localization of BDNF-, TrkB- and TrkA-like proteins in the teleost lateral line system |
topic_facet |
Original Articles |
description |
The lateral line system, formed of both superficial (pit organs) and canal neuromasts, is one of the major mechanosensory systems in fish. It has always been assumed that this system depends on neurotrophins and their cognate Trk receptors for development and maintenance, as has been shown in other mechanosensitive systems of vertebrates. However, until now this issue has not been specifically addressed. In this study we used immunohistochemistry to investigate the occurrence and localization both of neurotrophins (NGF-, BDNF- and NT-3-like) and of Trk-like proteins (TrkA-, TrkB-, TrkC-like) in alevins of Salmo salar and S. trutta. All cells in the pit organs of S. salar displayed strong immunoreactivity for TrkB-like and BDNF-like, whereas they were restricted to the hair cells in S. trutta. The hair, supporting and mantle cells of S. salar, and the mantle cells of S. trutta, also expressed TrkA-like immunoreactivity. In the canal neuromasts BDNF-, TrkA- and TrkB-like proteins were present in all cells, without differences between species. NGF-, NT-3- and TrkC-like immunoreactivity were never detected. The present results suggest that mechanoreceptive hair cells, as well as supporting cells, in the lateral line system are under the control of the BDNF–TrkB-like complex, and probably of ligands of TrkA-like receptors. |
format |
Text |
author |
Germana, A Catania, S Cavallaro, M González-Martínez, T Ciriaco, E Hannestad, J Vega, JA |
author_facet |
Germana, A Catania, S Cavallaro, M González-Martínez, T Ciriaco, E Hannestad, J Vega, JA |
author_sort |
Germana, A |
title |
Immunohistochemical localization of BDNF-, TrkB- and TrkA-like proteins in the teleost lateral line system |
title_short |
Immunohistochemical localization of BDNF-, TrkB- and TrkA-like proteins in the teleost lateral line system |
title_full |
Immunohistochemical localization of BDNF-, TrkB- and TrkA-like proteins in the teleost lateral line system |
title_fullStr |
Immunohistochemical localization of BDNF-, TrkB- and TrkA-like proteins in the teleost lateral line system |
title_full_unstemmed |
Immunohistochemical localization of BDNF-, TrkB- and TrkA-like proteins in the teleost lateral line system |
title_sort |
immunohistochemical localization of bdnf-, trkb- and trka-like proteins in the teleost lateral line system |
publisher |
Blackwell Science Inc |
publishDate |
2002 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1570709 http://www.ncbi.nlm.nih.gov/pubmed/12090394 https://doi.org/10.1046/j.1469-7580.2002.00055.x |
genre |
Salmo salar |
genre_facet |
Salmo salar |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1570709 http://www.ncbi.nlm.nih.gov/pubmed/12090394 http://dx.doi.org/10.1046/j.1469-7580.2002.00055.x |
op_rights |
© Anatomical Society of Great Britain and Ireland 2002 |
op_doi |
https://doi.org/10.1046/j.1469-7580.2002.00055.x |
container_title |
Journal of Anatomy |
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200 |
container_issue |
5 |
container_start_page |
477 |
op_container_end_page |
485 |
_version_ |
1766182612475314176 |