Radioallergosorbent testing for penicillin allergy in family practice.
OBJECTIVES: To determine (a) the prevalence of patients supposedly allergic to penicillin who have a positive radioallergosorbent test (RAST) result for penicillin G or V and (b) the predictive power of family physicians' clinical judgement that a patient who is supposedly allergic to penicilli...
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ftpubmed:oai:pubmedcentral.nih.gov:1485808 2023-05-15T17:22:34+02:00 Radioallergosorbent testing for penicillin allergy in family practice. Worrall, G J Hull, C Briffett, E 1994-01-01 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1485808 http://www.ncbi.nlm.nih.gov/pubmed/8275407 en eng http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1485808 http://www.ncbi.nlm.nih.gov/pubmed/8275407 Research Article Text 1994 ftpubmed 2013-08-31T02:40:08Z OBJECTIVES: To determine (a) the prevalence of patients supposedly allergic to penicillin who have a positive radioallergosorbent test (RAST) result for penicillin G or V and (b) the predictive power of family physicians' clinical judgement that a patient who is supposedly allergic to penicillin will have a positive RAST result. DESIGN: Prospective multicentre cross-sectional observational study. SETTING: Eleven primary care practices in Newfoundland; 10 were in a rural setting. PATIENTS: Of 110 consecutive adult patients with a supposed allergy to penicillin 97 agreed to participate in the study; 92 underwent RAST. INTERVENTIONS: Patients helped physicians complete a questionnaire and had a venous blood sample taken for the RAST. Physicians examined the clinical history and judged whether the patient was likely to have a positive RAST result. MEAN OUTCOME MEASURES: Rates of positive and negative RAST results for penicillin V and G. RESULTS: Of the 92 patients 8 had a positive RAST result and 84 a negative one. The positive predictive power of a "good" clinical history (e.g., urticaria, swollen eyes, tongue or lips, or an anaphylactic reaction witnessed by a physician) was low (10%); the negative predictive power of a "poor" clinical history (e.g., nausea, vomiting, diarrhea, fever, nonspecific rash or fainting) was 92%. CONCLUSIONS: Less than 10% of primary care patients with a supposed allergy to penicillin will have a positive RAST result. In addition, physicians' predictions of allergy in such patients are imprecise. Text Newfoundland PubMed Central (PMC) |
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Research Article Worrall, G J Hull, C Briffett, E Radioallergosorbent testing for penicillin allergy in family practice. |
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OBJECTIVES: To determine (a) the prevalence of patients supposedly allergic to penicillin who have a positive radioallergosorbent test (RAST) result for penicillin G or V and (b) the predictive power of family physicians' clinical judgement that a patient who is supposedly allergic to penicillin will have a positive RAST result. DESIGN: Prospective multicentre cross-sectional observational study. SETTING: Eleven primary care practices in Newfoundland; 10 were in a rural setting. PATIENTS: Of 110 consecutive adult patients with a supposed allergy to penicillin 97 agreed to participate in the study; 92 underwent RAST. INTERVENTIONS: Patients helped physicians complete a questionnaire and had a venous blood sample taken for the RAST. Physicians examined the clinical history and judged whether the patient was likely to have a positive RAST result. MEAN OUTCOME MEASURES: Rates of positive and negative RAST results for penicillin V and G. RESULTS: Of the 92 patients 8 had a positive RAST result and 84 a negative one. The positive predictive power of a "good" clinical history (e.g., urticaria, swollen eyes, tongue or lips, or an anaphylactic reaction witnessed by a physician) was low (10%); the negative predictive power of a "poor" clinical history (e.g., nausea, vomiting, diarrhea, fever, nonspecific rash or fainting) was 92%. CONCLUSIONS: Less than 10% of primary care patients with a supposed allergy to penicillin will have a positive RAST result. In addition, physicians' predictions of allergy in such patients are imprecise. |
format |
Text |
author |
Worrall, G J Hull, C Briffett, E |
author_facet |
Worrall, G J Hull, C Briffett, E |
author_sort |
Worrall, G J |
title |
Radioallergosorbent testing for penicillin allergy in family practice. |
title_short |
Radioallergosorbent testing for penicillin allergy in family practice. |
title_full |
Radioallergosorbent testing for penicillin allergy in family practice. |
title_fullStr |
Radioallergosorbent testing for penicillin allergy in family practice. |
title_full_unstemmed |
Radioallergosorbent testing for penicillin allergy in family practice. |
title_sort |
radioallergosorbent testing for penicillin allergy in family practice. |
publishDate |
1994 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1485808 http://www.ncbi.nlm.nih.gov/pubmed/8275407 |
genre |
Newfoundland |
genre_facet |
Newfoundland |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1485808 http://www.ncbi.nlm.nih.gov/pubmed/8275407 |
_version_ |
1766109295372402688 |