The mechanism of the inhibition by carbonic acid of the smooth muscle contraction produced by histamine and oxytocin
Carbonic acid inhibited the stimulating action of histamine on guinea-pig intestine and of oxytocin on the uterus of many animal species. This effect was relatively specific. Under the same conditions the actions of acetylcholine, KCl, adrenaline (on rabbit uterus), and ergot alkaloids were not inhi...
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ftpubmed:oai:pubmedcentral.nih.gov:1481818 2023-05-15T15:52:07+02:00 The mechanism of the inhibition by carbonic acid of the smooth muscle contraction produced by histamine and oxytocin Halpern, B. N. Binaghi, R. Mayer, M. Bugnard, C. 1959-03 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1481818 http://www.ncbi.nlm.nih.gov/pubmed/13651574 en eng http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1481818 http://www.ncbi.nlm.nih.gov/pubmed/13651574 Articles Text 1959 ftpubmed 2013-08-31T02:28:59Z Carbonic acid inhibited the stimulating action of histamine on guinea-pig intestine and of oxytocin on the uterus of many animal species. This effect was relatively specific. Under the same conditions the actions of acetylcholine, KCl, adrenaline (on rabbit uterus), and ergot alkaloids were not inhibited. The electrical excitability of smooth muscle was similarly not affected. The inhibitory action of carbonic acid is directly proportional to its concentration in the medium in which the isolated organ is maintained. The study of the activity of histamine and oxytocin at different pH in a medium free of NaHCO3 and buffered with a mixture of sodium maleate and maleic acid suggested that the inhibitory action exerted by carbonic acid was specific and independent of the simultaneous modifications of the hydrogen ion concentration. The mechanism of these phenomena is discussed. Text Carbonic acid PubMed Central (PMC) |
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Articles Halpern, B. N. Binaghi, R. Mayer, M. Bugnard, C. The mechanism of the inhibition by carbonic acid of the smooth muscle contraction produced by histamine and oxytocin |
topic_facet |
Articles |
description |
Carbonic acid inhibited the stimulating action of histamine on guinea-pig intestine and of oxytocin on the uterus of many animal species. This effect was relatively specific. Under the same conditions the actions of acetylcholine, KCl, adrenaline (on rabbit uterus), and ergot alkaloids were not inhibited. The electrical excitability of smooth muscle was similarly not affected. The inhibitory action of carbonic acid is directly proportional to its concentration in the medium in which the isolated organ is maintained. The study of the activity of histamine and oxytocin at different pH in a medium free of NaHCO3 and buffered with a mixture of sodium maleate and maleic acid suggested that the inhibitory action exerted by carbonic acid was specific and independent of the simultaneous modifications of the hydrogen ion concentration. The mechanism of these phenomena is discussed. |
format |
Text |
author |
Halpern, B. N. Binaghi, R. Mayer, M. Bugnard, C. |
author_facet |
Halpern, B. N. Binaghi, R. Mayer, M. Bugnard, C. |
author_sort |
Halpern, B. N. |
title |
The mechanism of the inhibition by carbonic acid of the smooth muscle contraction produced by histamine and oxytocin |
title_short |
The mechanism of the inhibition by carbonic acid of the smooth muscle contraction produced by histamine and oxytocin |
title_full |
The mechanism of the inhibition by carbonic acid of the smooth muscle contraction produced by histamine and oxytocin |
title_fullStr |
The mechanism of the inhibition by carbonic acid of the smooth muscle contraction produced by histamine and oxytocin |
title_full_unstemmed |
The mechanism of the inhibition by carbonic acid of the smooth muscle contraction produced by histamine and oxytocin |
title_sort |
mechanism of the inhibition by carbonic acid of the smooth muscle contraction produced by histamine and oxytocin |
publishDate |
1959 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1481818 http://www.ncbi.nlm.nih.gov/pubmed/13651574 |
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Carbonic acid |
genre_facet |
Carbonic acid |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1481818 http://www.ncbi.nlm.nih.gov/pubmed/13651574 |
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1766387417836683264 |