Sparteine oxidation polymorphism in Greenlanders living in Denmark.
Sparteine oxidation appeared to be polymorphic in 185 healthy Greenlanders living in Denmark. Six subjects (3.2%) were phenotyped as poor metabolizers (PM) and 179 subjects as extensive metabolizers (EM). The metabolic ratio (MR) between sparteine and 2- + 5-dehydrosparteine in a 12 h urine sample r...
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ftpubmed:oai:pubmedcentral.nih.gov:1401149 2023-05-15T16:30:57+02:00 Sparteine oxidation polymorphism in Greenlanders living in Denmark. Brøsen, K 1986-10 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1401149 http://www.ncbi.nlm.nih.gov/pubmed/3768256 en eng http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1401149 http://www.ncbi.nlm.nih.gov/pubmed/3768256 Research Article Text 1986 ftpubmed 2013-08-30T22:38:49Z Sparteine oxidation appeared to be polymorphic in 185 healthy Greenlanders living in Denmark. Six subjects (3.2%) were phenotyped as poor metabolizers (PM) and 179 subjects as extensive metabolizers (EM). The metabolic ratio (MR) between sparteine and 2- + 5-dehydrosparteine in a 12 h urine sample ranged from 0.06-3.12 in EM and from 30-480 in PM. The excretion of dehydrosparteines accounted for less than 2.2% of the dose in PM and ranged from 5.6%-63% in EM. The urinary recovery (% of dose) of sparteine, 2-dehydrosparteine and total sparteine + dehydrosparteines was lower in Greenlander EM than in Danish EM (Brøsen et al., 1985). Incomplete urine collection in a substantial proportion of the Greenlanders could explain these discrepancies. Text greenlander* PubMed Central (PMC) |
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Research Article Brøsen, K Sparteine oxidation polymorphism in Greenlanders living in Denmark. |
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Research Article |
description |
Sparteine oxidation appeared to be polymorphic in 185 healthy Greenlanders living in Denmark. Six subjects (3.2%) were phenotyped as poor metabolizers (PM) and 179 subjects as extensive metabolizers (EM). The metabolic ratio (MR) between sparteine and 2- + 5-dehydrosparteine in a 12 h urine sample ranged from 0.06-3.12 in EM and from 30-480 in PM. The excretion of dehydrosparteines accounted for less than 2.2% of the dose in PM and ranged from 5.6%-63% in EM. The urinary recovery (% of dose) of sparteine, 2-dehydrosparteine and total sparteine + dehydrosparteines was lower in Greenlander EM than in Danish EM (Brøsen et al., 1985). Incomplete urine collection in a substantial proportion of the Greenlanders could explain these discrepancies. |
format |
Text |
author |
Brøsen, K |
author_facet |
Brøsen, K |
author_sort |
Brøsen, K |
title |
Sparteine oxidation polymorphism in Greenlanders living in Denmark. |
title_short |
Sparteine oxidation polymorphism in Greenlanders living in Denmark. |
title_full |
Sparteine oxidation polymorphism in Greenlanders living in Denmark. |
title_fullStr |
Sparteine oxidation polymorphism in Greenlanders living in Denmark. |
title_full_unstemmed |
Sparteine oxidation polymorphism in Greenlanders living in Denmark. |
title_sort |
sparteine oxidation polymorphism in greenlanders living in denmark. |
publishDate |
1986 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1401149 http://www.ncbi.nlm.nih.gov/pubmed/3768256 |
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greenlander* |
genre_facet |
greenlander* |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1401149 http://www.ncbi.nlm.nih.gov/pubmed/3768256 |
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1766020772097163264 |