Genetic linkage analysis of manic depression in Iceland.
Genetic linkage analysis has been used to study five Icelandic pedigrees multiply affected with manic depression. Genetic markers were chosen from regions which had been implicated by other studies or to which candidate genes had been localized. The transmission model used was of a dominant gene wit...
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ftpubmed:oai:pubmedcentral.nih.gov:1294094 2023-05-15T16:49:17+02:00 Genetic linkage analysis of manic depression in Iceland. Curtis, D Sherrington, R Brett, P Holmes, D S Kalsi, G Brynjolfsson, J Petursson, H Rifkin, L Murphy, P Moloney, E 1993-09 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1294094 http://www.ncbi.nlm.nih.gov/pubmed/8105081 en eng http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1294094 http://www.ncbi.nlm.nih.gov/pubmed/8105081 Research Article Text 1993 ftpubmed 2013-08-30T17:36:58Z Genetic linkage analysis has been used to study five Icelandic pedigrees multiply affected with manic depression. Genetic markers were chosen from regions which had been implicated by other studies or to which candidate genes had been localized. The transmission model used was of a dominant gene with incomplete penetrance and allowing for a large number of phenocopies, especially for unipolar rather than bipolar cases. Multipoint analysis with linked markers enabled information to be gained from regions spanning large distances. Using this approach we have excluded regions of chromosome 11p, 11q, 8q, 5q, 9q and Xq. Candidate genes excluded include those for tyrosine hydroxylase, the dopamine type 2 receptor, proenkephalin, the 5HT1A receptor and dopamine beta hydroxylase. Nevertheless, we remain optimistic that this approach will eventually identify at least some of the genes predisposing to manic depression. Text Iceland PubMed Central (PMC) |
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Research Article |
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Research Article Curtis, D Sherrington, R Brett, P Holmes, D S Kalsi, G Brynjolfsson, J Petursson, H Rifkin, L Murphy, P Moloney, E Genetic linkage analysis of manic depression in Iceland. |
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Research Article |
description |
Genetic linkage analysis has been used to study five Icelandic pedigrees multiply affected with manic depression. Genetic markers were chosen from regions which had been implicated by other studies or to which candidate genes had been localized. The transmission model used was of a dominant gene with incomplete penetrance and allowing for a large number of phenocopies, especially for unipolar rather than bipolar cases. Multipoint analysis with linked markers enabled information to be gained from regions spanning large distances. Using this approach we have excluded regions of chromosome 11p, 11q, 8q, 5q, 9q and Xq. Candidate genes excluded include those for tyrosine hydroxylase, the dopamine type 2 receptor, proenkephalin, the 5HT1A receptor and dopamine beta hydroxylase. Nevertheless, we remain optimistic that this approach will eventually identify at least some of the genes predisposing to manic depression. |
format |
Text |
author |
Curtis, D Sherrington, R Brett, P Holmes, D S Kalsi, G Brynjolfsson, J Petursson, H Rifkin, L Murphy, P Moloney, E |
author_facet |
Curtis, D Sherrington, R Brett, P Holmes, D S Kalsi, G Brynjolfsson, J Petursson, H Rifkin, L Murphy, P Moloney, E |
author_sort |
Curtis, D |
title |
Genetic linkage analysis of manic depression in Iceland. |
title_short |
Genetic linkage analysis of manic depression in Iceland. |
title_full |
Genetic linkage analysis of manic depression in Iceland. |
title_fullStr |
Genetic linkage analysis of manic depression in Iceland. |
title_full_unstemmed |
Genetic linkage analysis of manic depression in Iceland. |
title_sort |
genetic linkage analysis of manic depression in iceland. |
publishDate |
1993 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1294094 http://www.ncbi.nlm.nih.gov/pubmed/8105081 |
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Iceland |
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Iceland |
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1294094 http://www.ncbi.nlm.nih.gov/pubmed/8105081 |
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1766039448279056384 |