Umbilical Cord Mercury Concentration as Biomarker of Prenatal Exposure to Methylmercury
Biomarkers are often applied to assess prenatal exposure to methylmercury in research and surveillance. In a prospective study in the Faroe Islands, the main exposure biomarkers were the mercury concentrations in cord blood and maternal hair obtained at parturition. We have now supplemented these ex...
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ftpubmed:oai:pubmedcentral.nih.gov:1257654 2023-05-15T16:10:51+02:00 Umbilical Cord Mercury Concentration as Biomarker of Prenatal Exposure to Methylmercury Grandjean, Philippe Budtz-Jørgensen, Esben Jørgensen, Poul J. Weihe, Pál 2005-07 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1257654 http://www.ncbi.nlm.nih.gov/pubmed/16002381 https://doi.org/10.1289/ehp.7842 en eng National Institue of Environmental Health Sciences http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1257654 http://www.ncbi.nlm.nih.gov/pubmed/16002381 http://dx.doi.org/10.1289/ehp.7842 This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original DOI. Research Text 2005 ftpubmed https://doi.org/10.1289/ehp.7842 2013-08-30T15:54:39Z Biomarkers are often applied to assess prenatal exposure to methylmercury in research and surveillance. In a prospective study in the Faroe Islands, the main exposure biomarkers were the mercury concentrations in cord blood and maternal hair obtained at parturition. We have now supplemented these exposure biomarkers with mercury analyses of umbilical cord tissue from 447 births. In particular, when expressed in relation to the dry weight of the tissue, the cord mercury concentration correlated very well with that in cord blood. Structural equation model analysis showed that these two biomarkers have average total imprecision of about 30%, which is much higher than the laboratory error. The imprecision of the dry-weight–based concentration was lower than that of the wet-weight–based parameter, and it was intermediate between those of the cord blood and the hair biomarkers. In agreement with this finding, regression analyses showed that the dry-weight cord mercury concentration was almost as good a predictor of methylmercury-associated neuropsychologic deficits at 7 years of age as was the cord-blood mercury concentration. Cord mercury analysis can therefore be used as a valid measure of prenatal methylmercury exposure, but appropriate adjustment for the imprecision should be considered. Text Faroe Islands PubMed Central (PMC) Faroe Islands Environmental Health Perspectives 113 7 905 908 |
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Research Grandjean, Philippe Budtz-Jørgensen, Esben Jørgensen, Poul J. Weihe, Pál Umbilical Cord Mercury Concentration as Biomarker of Prenatal Exposure to Methylmercury |
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Biomarkers are often applied to assess prenatal exposure to methylmercury in research and surveillance. In a prospective study in the Faroe Islands, the main exposure biomarkers were the mercury concentrations in cord blood and maternal hair obtained at parturition. We have now supplemented these exposure biomarkers with mercury analyses of umbilical cord tissue from 447 births. In particular, when expressed in relation to the dry weight of the tissue, the cord mercury concentration correlated very well with that in cord blood. Structural equation model analysis showed that these two biomarkers have average total imprecision of about 30%, which is much higher than the laboratory error. The imprecision of the dry-weight–based concentration was lower than that of the wet-weight–based parameter, and it was intermediate between those of the cord blood and the hair biomarkers. In agreement with this finding, regression analyses showed that the dry-weight cord mercury concentration was almost as good a predictor of methylmercury-associated neuropsychologic deficits at 7 years of age as was the cord-blood mercury concentration. Cord mercury analysis can therefore be used as a valid measure of prenatal methylmercury exposure, but appropriate adjustment for the imprecision should be considered. |
format |
Text |
author |
Grandjean, Philippe Budtz-Jørgensen, Esben Jørgensen, Poul J. Weihe, Pál |
author_facet |
Grandjean, Philippe Budtz-Jørgensen, Esben Jørgensen, Poul J. Weihe, Pál |
author_sort |
Grandjean, Philippe |
title |
Umbilical Cord Mercury Concentration as Biomarker of Prenatal Exposure to Methylmercury |
title_short |
Umbilical Cord Mercury Concentration as Biomarker of Prenatal Exposure to Methylmercury |
title_full |
Umbilical Cord Mercury Concentration as Biomarker of Prenatal Exposure to Methylmercury |
title_fullStr |
Umbilical Cord Mercury Concentration as Biomarker of Prenatal Exposure to Methylmercury |
title_full_unstemmed |
Umbilical Cord Mercury Concentration as Biomarker of Prenatal Exposure to Methylmercury |
title_sort |
umbilical cord mercury concentration as biomarker of prenatal exposure to methylmercury |
publisher |
National Institue of Environmental Health Sciences |
publishDate |
2005 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1257654 http://www.ncbi.nlm.nih.gov/pubmed/16002381 https://doi.org/10.1289/ehp.7842 |
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Faroe Islands |
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Faroe Islands |
genre |
Faroe Islands |
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Faroe Islands |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1257654 http://www.ncbi.nlm.nih.gov/pubmed/16002381 http://dx.doi.org/10.1289/ehp.7842 |
op_rights |
This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original DOI. |
op_doi |
https://doi.org/10.1289/ehp.7842 |
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Environmental Health Perspectives |
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113 |
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7 |
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908 |
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