Acute Infections and Environmental Exposure to Organochlorines in Inuit Infants from Nunavik
The Inuit population of Nunavik (Canada) is exposed to immunotoxic organochlorines (OCs) mainly through the consumption of fish and marine mammal fat. We investigated the effect of perinatal exposure to polychlorinated biphenyls (PCBs) and dichlorodiphenyldichloroethylene (DDE) on the incidence of a...
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ftpubmed:oai:pubmedcentral.nih.gov:1247560 2023-05-15T16:54:40+02:00 Acute Infections and Environmental Exposure to Organochlorines in Inuit Infants from Nunavik Dallaire, Frédéric Dewailly, Éric Muckle, Gina Vézina, Carole Jacobson, Sandra W. Jacobson, Joseph L. Ayotte, Pierre 2004-10 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1247560 http://www.ncbi.nlm.nih.gov/pubmed/15471725 https://doi.org/10.1289/ehp.7255 en eng National Institue of Environmental Health Sciences http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1247560 http://www.ncbi.nlm.nih.gov/pubmed/15471725 http://dx.doi.org/10.1289/ehp.7255 This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original DOI. Environmental Medicine Text 2004 ftpubmed https://doi.org/10.1289/ehp.7255 2013-08-30T15:26:13Z The Inuit population of Nunavik (Canada) is exposed to immunotoxic organochlorines (OCs) mainly through the consumption of fish and marine mammal fat. We investigated the effect of perinatal exposure to polychlorinated biphenyls (PCBs) and dichlorodiphenyldichloroethylene (DDE) on the incidence of acute infections in Inuit infants. We reviewed the medical charts of a cohort of 199 Inuit infants during the first 12 months of life and evaluated the incidence rates of upper and lower respiratory tract infections (URTI and LRTIs, respectively), otitis media, and gastrointestinal (GI) infections. Maternal plasma during delivery and infant plasma at 7 months of age were sampled and assayed for PCBs and DDE. Compared to rates for infants in the first quartile of exposure to PCBs (least exposed), adjusted rate ratios for infants in higher quartiles ranged between 1.09 and 1.32 for URTIs, 0.99 and 1.39 for otitis, 1.52 and 1.89 for GI infections, and 1.16 and 1.68 for LRTIs during the first 6 months of follow-up. For all infections combined, the rate ratios ranged from 1.17 to 1.27. The effect size was similar for DDE exposure but was lower for the full 12-month follow-up. Globally, most rate ratios were > 1.0, but few were statistically significant (p < 0.05). No association was found when postnatal exposure was considered. These results show a possible association between prenatal exposure to OCs and acute infections early in life in this Inuit population. Text inuit Nunavik PubMed Central (PMC) Canada Nunavik Environmental Health Perspectives 112 14 1359 1364 |
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English |
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Environmental Medicine |
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Environmental Medicine Dallaire, Frédéric Dewailly, Éric Muckle, Gina Vézina, Carole Jacobson, Sandra W. Jacobson, Joseph L. Ayotte, Pierre Acute Infections and Environmental Exposure to Organochlorines in Inuit Infants from Nunavik |
topic_facet |
Environmental Medicine |
description |
The Inuit population of Nunavik (Canada) is exposed to immunotoxic organochlorines (OCs) mainly through the consumption of fish and marine mammal fat. We investigated the effect of perinatal exposure to polychlorinated biphenyls (PCBs) and dichlorodiphenyldichloroethylene (DDE) on the incidence of acute infections in Inuit infants. We reviewed the medical charts of a cohort of 199 Inuit infants during the first 12 months of life and evaluated the incidence rates of upper and lower respiratory tract infections (URTI and LRTIs, respectively), otitis media, and gastrointestinal (GI) infections. Maternal plasma during delivery and infant plasma at 7 months of age were sampled and assayed for PCBs and DDE. Compared to rates for infants in the first quartile of exposure to PCBs (least exposed), adjusted rate ratios for infants in higher quartiles ranged between 1.09 and 1.32 for URTIs, 0.99 and 1.39 for otitis, 1.52 and 1.89 for GI infections, and 1.16 and 1.68 for LRTIs during the first 6 months of follow-up. For all infections combined, the rate ratios ranged from 1.17 to 1.27. The effect size was similar for DDE exposure but was lower for the full 12-month follow-up. Globally, most rate ratios were > 1.0, but few were statistically significant (p < 0.05). No association was found when postnatal exposure was considered. These results show a possible association between prenatal exposure to OCs and acute infections early in life in this Inuit population. |
format |
Text |
author |
Dallaire, Frédéric Dewailly, Éric Muckle, Gina Vézina, Carole Jacobson, Sandra W. Jacobson, Joseph L. Ayotte, Pierre |
author_facet |
Dallaire, Frédéric Dewailly, Éric Muckle, Gina Vézina, Carole Jacobson, Sandra W. Jacobson, Joseph L. Ayotte, Pierre |
author_sort |
Dallaire, Frédéric |
title |
Acute Infections and Environmental Exposure to Organochlorines in Inuit Infants from Nunavik |
title_short |
Acute Infections and Environmental Exposure to Organochlorines in Inuit Infants from Nunavik |
title_full |
Acute Infections and Environmental Exposure to Organochlorines in Inuit Infants from Nunavik |
title_fullStr |
Acute Infections and Environmental Exposure to Organochlorines in Inuit Infants from Nunavik |
title_full_unstemmed |
Acute Infections and Environmental Exposure to Organochlorines in Inuit Infants from Nunavik |
title_sort |
acute infections and environmental exposure to organochlorines in inuit infants from nunavik |
publisher |
National Institue of Environmental Health Sciences |
publishDate |
2004 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1247560 http://www.ncbi.nlm.nih.gov/pubmed/15471725 https://doi.org/10.1289/ehp.7255 |
geographic |
Canada Nunavik |
geographic_facet |
Canada Nunavik |
genre |
inuit Nunavik |
genre_facet |
inuit Nunavik |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1247560 http://www.ncbi.nlm.nih.gov/pubmed/15471725 http://dx.doi.org/10.1289/ehp.7255 |
op_rights |
This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original DOI. |
op_doi |
https://doi.org/10.1289/ehp.7255 |
container_title |
Environmental Health Perspectives |
container_volume |
112 |
container_issue |
14 |
container_start_page |
1359 |
op_container_end_page |
1364 |
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1766045379568074752 |