Environmental exposure to polychlorinated biphenyls and placental CYP1A1 activity in Inuit women from northern Québec.
Some polychlorinated biphenyl (PCB) congeners are CYP1A1 inducers, and induction of this enzyme in the placenta has been linked to adverse effects on fetal development. The objective of this study was to determine if the body burden of PCBs is related to placental CYP1A1 activity in Inuit women from...
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ftpubmed:oai:pubmedcentral.nih.gov:1240878 2023-05-15T16:54:44+02:00 Environmental exposure to polychlorinated biphenyls and placental CYP1A1 activity in Inuit women from northern Québec. Pereg, Daria Dewailly, Eric Poirier, Guy G Ayotte, Pierre 2002-06 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1240878 http://www.ncbi.nlm.nih.gov/pubmed/12055053 en eng http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1240878 http://www.ncbi.nlm.nih.gov/pubmed/12055053 Research Article Text 2002 ftpubmed 2013-08-30T15:06:24Z Some polychlorinated biphenyl (PCB) congeners are CYP1A1 inducers, and induction of this enzyme in the placenta has been linked to adverse effects on fetal development. The objective of this study was to determine if the body burden of PCBs is related to placental CYP1A1 activity in Inuit women from Nunavik (northern Québec), a population highly exposed to organochlorines. Placenta and cord blood samples were obtained from 35 Inuit women and 30 women from a southern Québec community exposed to background levels of organochlorines. We measured PCB concentrations in all cord plasma samples and in a subset of placenta samples from the Nunavik group and assessed CYP1A1 activity (ethoxyresorufin-O-deethylase; EROD) in placental microsomes from all participants. Concentrations of PCBs in cord plasma were strongly correlated to those in placenta (Pearson's r) = 0.77-0.97, p < 0.001) and were on average 4-fold higher in Inuit women than in southern Québec women [for PCB 153, the geometric means (geometric SDs) were 83.3 (1.9) ng/g lipid vs. 16.9 (1.6) ng/g lipid, respectively]. Despite this difference in PCB body burden, both study groups had similar EROD activities when data were stratified according to tobacco smoking. Although simple correlation analysis first showed that placental EROD activity was correlated with PCB 153 plasma concentration in the Nunavik group, a multivariate analysis failed to demonstrate a significant contribution of PCBs to EROD activity when tobacco smoking was included in the analysis. We conclude that dietary exposure to PCBs in Inuit women from Nunavik does not significantly influence EROD activity in the placenta, implicating tobacco smoking as the major modulating factor. Text inuit Nunavik PubMed Central (PMC) Nunavik |
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Research Article Pereg, Daria Dewailly, Eric Poirier, Guy G Ayotte, Pierre Environmental exposure to polychlorinated biphenyls and placental CYP1A1 activity in Inuit women from northern Québec. |
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Research Article |
description |
Some polychlorinated biphenyl (PCB) congeners are CYP1A1 inducers, and induction of this enzyme in the placenta has been linked to adverse effects on fetal development. The objective of this study was to determine if the body burden of PCBs is related to placental CYP1A1 activity in Inuit women from Nunavik (northern Québec), a population highly exposed to organochlorines. Placenta and cord blood samples were obtained from 35 Inuit women and 30 women from a southern Québec community exposed to background levels of organochlorines. We measured PCB concentrations in all cord plasma samples and in a subset of placenta samples from the Nunavik group and assessed CYP1A1 activity (ethoxyresorufin-O-deethylase; EROD) in placental microsomes from all participants. Concentrations of PCBs in cord plasma were strongly correlated to those in placenta (Pearson's r) = 0.77-0.97, p < 0.001) and were on average 4-fold higher in Inuit women than in southern Québec women [for PCB 153, the geometric means (geometric SDs) were 83.3 (1.9) ng/g lipid vs. 16.9 (1.6) ng/g lipid, respectively]. Despite this difference in PCB body burden, both study groups had similar EROD activities when data were stratified according to tobacco smoking. Although simple correlation analysis first showed that placental EROD activity was correlated with PCB 153 plasma concentration in the Nunavik group, a multivariate analysis failed to demonstrate a significant contribution of PCBs to EROD activity when tobacco smoking was included in the analysis. We conclude that dietary exposure to PCBs in Inuit women from Nunavik does not significantly influence EROD activity in the placenta, implicating tobacco smoking as the major modulating factor. |
format |
Text |
author |
Pereg, Daria Dewailly, Eric Poirier, Guy G Ayotte, Pierre |
author_facet |
Pereg, Daria Dewailly, Eric Poirier, Guy G Ayotte, Pierre |
author_sort |
Pereg, Daria |
title |
Environmental exposure to polychlorinated biphenyls and placental CYP1A1 activity in Inuit women from northern Québec. |
title_short |
Environmental exposure to polychlorinated biphenyls and placental CYP1A1 activity in Inuit women from northern Québec. |
title_full |
Environmental exposure to polychlorinated biphenyls and placental CYP1A1 activity in Inuit women from northern Québec. |
title_fullStr |
Environmental exposure to polychlorinated biphenyls and placental CYP1A1 activity in Inuit women from northern Québec. |
title_full_unstemmed |
Environmental exposure to polychlorinated biphenyls and placental CYP1A1 activity in Inuit women from northern Québec. |
title_sort |
environmental exposure to polychlorinated biphenyls and placental cyp1a1 activity in inuit women from northern québec. |
publishDate |
2002 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1240878 http://www.ncbi.nlm.nih.gov/pubmed/12055053 |
geographic |
Nunavik |
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Nunavik |
genre |
inuit Nunavik |
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inuit Nunavik |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1240878 http://www.ncbi.nlm.nih.gov/pubmed/12055053 |
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1766045491553894400 |