Structural determinants of fluoride and formate binding to hemoglobin and myoglobin: crystallographic and 1H-NMR relaxometric study.

• Main Authors: Aime, S, Fasano, M, Paoletti, S, Cutruzzolà, F, Desideri, A, Bolognesi, M, Rizzi, M, Ascenzi, P
• Format: Text
• Language: English
• Published: 1996
• Subjects: Research Article; Catodon; Sperm whale
• Online Access: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1224947; http://www.ncbi.nlm.nih.gov/pubmed/8770225

The x-ray crystal structure of the fluoride derivative of ferric sperm whale (Physeter catodon) myoglobin (Mb) has been determined at 2.5 A resolution (R = 0.187) by difference Fourier techniques. The fluoride anion, sitting in the central part of the heme distal site and coordinated to the heme iro...