Localization of a Gene for Migraine without Aura to Chromosome 4q21
Migraine is a common form of headache and has a significant genetic component. Here, we report linkage results from a study in Iceland of migraine without aura (MO). The study group comprised patients with migraine recruited by neurologists and from the registry of the Icelandic Migraine Society, as...
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ftpubmed:oai:pubmedcentral.nih.gov:1180504 2023-05-15T16:50:08+02:00 Localization of a Gene for Migraine without Aura to Chromosome 4q21 Björnsson, Ásgeir Gudmundsson, Grétar Gudfinnsson, Einar Hrafnsdóttir, María Benedikz, John Skúladóttir, Svanhildur Kristjánsson, Kristleifur Frigge, Michael L. Kong, Augustine Stefánsson, Kári Gulcher, Jeffrey R. 2003-11 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1180504 http://www.ncbi.nlm.nih.gov/pubmed/14513409 en eng The American Society of Human Genetics http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1180504 http://www.ncbi.nlm.nih.gov/pubmed/14513409 © 2003 by The American Society of Human Genetics. All rights reserved. Articles Text 2003 ftpubmed 2013-08-30T12:05:11Z Migraine is a common form of headache and has a significant genetic component. Here, we report linkage results from a study in Iceland of migraine without aura (MO). The study group comprised patients with migraine recruited by neurologists and from the registry of the Icelandic Migraine Society, as well as through the use of a questionnaire sent to a random sample of 20,000 Icelanders. Migraine diagnoses were made and confirmed using diagnostic criteria established by the International Headache Society. A genomewide scan with multipoint allele-sharing methods was performed on 289 patients suffering from MO. Linkage was observed to a locus on chromosome 4q21 (LOD=2.05; P=.001). The locus reported here overlaps a locus (MGR1) reported elsewhere for patients with migraine with aura (MA) in the Finnish population. This replication of the MGR1 locus in families with MO indicates that the gene we have mapped may contribute to both MA and MO. Further analysis indicates that the linkage evidence improves for affected females and, especially, with a slightly relaxed definition of MO (LOD=4.08; P=7.2×10-6). Text Iceland PubMed Central (PMC) |
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Articles Björnsson, Ásgeir Gudmundsson, Grétar Gudfinnsson, Einar Hrafnsdóttir, María Benedikz, John Skúladóttir, Svanhildur Kristjánsson, Kristleifur Frigge, Michael L. Kong, Augustine Stefánsson, Kári Gulcher, Jeffrey R. Localization of a Gene for Migraine without Aura to Chromosome 4q21 |
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Migraine is a common form of headache and has a significant genetic component. Here, we report linkage results from a study in Iceland of migraine without aura (MO). The study group comprised patients with migraine recruited by neurologists and from the registry of the Icelandic Migraine Society, as well as through the use of a questionnaire sent to a random sample of 20,000 Icelanders. Migraine diagnoses were made and confirmed using diagnostic criteria established by the International Headache Society. A genomewide scan with multipoint allele-sharing methods was performed on 289 patients suffering from MO. Linkage was observed to a locus on chromosome 4q21 (LOD=2.05; P=.001). The locus reported here overlaps a locus (MGR1) reported elsewhere for patients with migraine with aura (MA) in the Finnish population. This replication of the MGR1 locus in families with MO indicates that the gene we have mapped may contribute to both MA and MO. Further analysis indicates that the linkage evidence improves for affected females and, especially, with a slightly relaxed definition of MO (LOD=4.08; P=7.2×10-6). |
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Text |
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Björnsson, Ásgeir Gudmundsson, Grétar Gudfinnsson, Einar Hrafnsdóttir, María Benedikz, John Skúladóttir, Svanhildur Kristjánsson, Kristleifur Frigge, Michael L. Kong, Augustine Stefánsson, Kári Gulcher, Jeffrey R. |
author_facet |
Björnsson, Ásgeir Gudmundsson, Grétar Gudfinnsson, Einar Hrafnsdóttir, María Benedikz, John Skúladóttir, Svanhildur Kristjánsson, Kristleifur Frigge, Michael L. Kong, Augustine Stefánsson, Kári Gulcher, Jeffrey R. |
author_sort |
Björnsson, Ásgeir |
title |
Localization of a Gene for Migraine without Aura to Chromosome 4q21 |
title_short |
Localization of a Gene for Migraine without Aura to Chromosome 4q21 |
title_full |
Localization of a Gene for Migraine without Aura to Chromosome 4q21 |
title_fullStr |
Localization of a Gene for Migraine without Aura to Chromosome 4q21 |
title_full_unstemmed |
Localization of a Gene for Migraine without Aura to Chromosome 4q21 |
title_sort |
localization of a gene for migraine without aura to chromosome 4q21 |
publisher |
The American Society of Human Genetics |
publishDate |
2003 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1180504 http://www.ncbi.nlm.nih.gov/pubmed/14513409 |
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Iceland |
genre_facet |
Iceland |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1180504 http://www.ncbi.nlm.nih.gov/pubmed/14513409 |
op_rights |
© 2003 by The American Society of Human Genetics. All rights reserved. |
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