Characterization of a New Species of Adenovirus in Falcons

• Published in: Journal of Clinical Microbiology
• Main Authors: Schrenzel, Mark, Oaks, J. Lindsay, Rotstein, Dave, Maalouf, Gabriel, Snook, Eric, Sandfort, Cal, Rideout, Bruce
• Format: Text
• Language: English
• Published: American Society for Microbiology 2005
• Subjects: Clinical Veterinary Microbiology; Falco peregrinus; Falco rusticolus; gyrfalcon; peregrine falcon
• Online Access: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1169131; http://www.ncbi.nlm.nih.gov/pubmed/16000466; https://doi.org/10.1128/JCM.43.7.3402-3413.2005

In 1996, a disease outbreak occurred at a captive breeding facility in Idaho, causing anorexia, dehydration, and diarrhea or sudden death in 72 of 110 Northern aplomado falcons (Falco femoralis septentrionalis) from 9 to 35 days of age and in 6 of 102 peregrine falcons (Falco peregrinus) from 14 to 25 days of age. Sixty-two Northern aplomado and six peregrine falcons died. Epidemiologic analyses indicated a point source epizootic, horizontal transmission, and increased relative risk associated with cross-species brooding of eggs. Primary lesions in affected birds were inclusion body hepatitis, splenomegaly, and enteritis. The etiology in all mortalities was determined by molecular analyses to be a new species of adenovirus distantly related to the group I avian viruses, serotypes 1 and 4, Aviadenovirus. In situ hybridization and PCR demonstrated that the virus was epitheliotropic and lymphotropic and that infection was systemic in the majority of animals. Adeno-associated virus was also detected by PCR in most affected falcons, but no other infectious agents or predisposing factors were found in any birds. Subsequent to the 1996 epizootic, a similar disease caused by the same adenovirus was found over a 5-year period in orange-breasted falcons (Falco deiroleucus), teita falcons (Falco fasciinucha), a merlin (Falco columbarius), a Vanuatu peregrine falcon (Falco peregrinus nesiotes), and gyrfalcon × peregrine falcon hybrids (Falco rusticolus/peregrinus) that died in Wyoming, Oklahoma, Minnesota, and California. These findings indicate that this newly recognized adenovirus is widespread in western and midwestern North America and can be a primary pathogen in different falcon species.