The role of recombination dynamics in shaping signatures of direct and indirect selection across the Ficedula flycatcher genome(†)
Recombination is a central evolutionary process that reshuffles combinations of alleles along chromosomes, and consequently is expected to influence the efficacy of direct selection via Hill–Robertson interference. Additionally, the indirect effects of selection on neutral genetic diversity are expe...
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ftpubmed:oai:pubmedcentral.nih.gov:10791521 2024-02-11T10:09:04+01:00 The role of recombination dynamics in shaping signatures of direct and indirect selection across the Ficedula flycatcher genome(†) Chase, Madeline A. Vilcot, Maurine Mugal, Carina F. 2024-01-17 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10791521/ http://www.ncbi.nlm.nih.gov/pubmed/38228173 https://doi.org/10.1098/rspb.2023.2382 en eng The Royal Society http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10791521/ http://www.ncbi.nlm.nih.gov/pubmed/38228173 http://dx.doi.org/10.1098/rspb.2023.2382 © 2024 The Authors. https://creativecommons.org/licenses/by/4.0/Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, provided the original author and source are credited. Proc Biol Sci Evolution Text 2024 ftpubmed https://doi.org/10.1098/rspb.2023.2382 2024-01-21T01:51:31Z Recombination is a central evolutionary process that reshuffles combinations of alleles along chromosomes, and consequently is expected to influence the efficacy of direct selection via Hill–Robertson interference. Additionally, the indirect effects of selection on neutral genetic diversity are expected to show a negative relationship with recombination rate, as background selection and genetic hitchhiking are stronger when recombination rate is low. However, owing to the limited availability of recombination rate estimates across divergent species, the impact of evolutionary changes in recombination rate on genomic signatures of selection remains largely unexplored. To address this question, we estimate recombination rate in two Ficedula flycatcher species, the taiga flycatcher (Ficedula albicilla) and collared flycatcher (Ficedula albicollis). We show that recombination rate is strongly correlated with signatures of indirect selection, and that evolutionary changes in recombination rate between species have observable impacts on this relationship. Conversely, signatures of direct selection on coding sequences show little to no relationship with recombination rate, even when restricted to genes where recombination rate is conserved between species. Thus, using measures of indirect and direct selection that bridge micro- and macro-evolutionary timescales, we demonstrate that the role of recombination rate and its dynamics varies for different signatures of selection. Text taiga PubMed Central (PMC) Proceedings of the Royal Society B: Biological Sciences 291 2015 |
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English |
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Evolution |
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Evolution Chase, Madeline A. Vilcot, Maurine Mugal, Carina F. The role of recombination dynamics in shaping signatures of direct and indirect selection across the Ficedula flycatcher genome(†) |
topic_facet |
Evolution |
description |
Recombination is a central evolutionary process that reshuffles combinations of alleles along chromosomes, and consequently is expected to influence the efficacy of direct selection via Hill–Robertson interference. Additionally, the indirect effects of selection on neutral genetic diversity are expected to show a negative relationship with recombination rate, as background selection and genetic hitchhiking are stronger when recombination rate is low. However, owing to the limited availability of recombination rate estimates across divergent species, the impact of evolutionary changes in recombination rate on genomic signatures of selection remains largely unexplored. To address this question, we estimate recombination rate in two Ficedula flycatcher species, the taiga flycatcher (Ficedula albicilla) and collared flycatcher (Ficedula albicollis). We show that recombination rate is strongly correlated with signatures of indirect selection, and that evolutionary changes in recombination rate between species have observable impacts on this relationship. Conversely, signatures of direct selection on coding sequences show little to no relationship with recombination rate, even when restricted to genes where recombination rate is conserved between species. Thus, using measures of indirect and direct selection that bridge micro- and macro-evolutionary timescales, we demonstrate that the role of recombination rate and its dynamics varies for different signatures of selection. |
format |
Text |
author |
Chase, Madeline A. Vilcot, Maurine Mugal, Carina F. |
author_facet |
Chase, Madeline A. Vilcot, Maurine Mugal, Carina F. |
author_sort |
Chase, Madeline A. |
title |
The role of recombination dynamics in shaping signatures of direct and indirect selection across the Ficedula flycatcher genome(†) |
title_short |
The role of recombination dynamics in shaping signatures of direct and indirect selection across the Ficedula flycatcher genome(†) |
title_full |
The role of recombination dynamics in shaping signatures of direct and indirect selection across the Ficedula flycatcher genome(†) |
title_fullStr |
The role of recombination dynamics in shaping signatures of direct and indirect selection across the Ficedula flycatcher genome(†) |
title_full_unstemmed |
The role of recombination dynamics in shaping signatures of direct and indirect selection across the Ficedula flycatcher genome(†) |
title_sort |
role of recombination dynamics in shaping signatures of direct and indirect selection across the ficedula flycatcher genome(†) |
publisher |
The Royal Society |
publishDate |
2024 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10791521/ http://www.ncbi.nlm.nih.gov/pubmed/38228173 https://doi.org/10.1098/rspb.2023.2382 |
genre |
taiga |
genre_facet |
taiga |
op_source |
Proc Biol Sci |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10791521/ http://www.ncbi.nlm.nih.gov/pubmed/38228173 http://dx.doi.org/10.1098/rspb.2023.2382 |
op_rights |
© 2024 The Authors. https://creativecommons.org/licenses/by/4.0/Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, provided the original author and source are credited. |
op_doi |
https://doi.org/10.1098/rspb.2023.2382 |
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Proceedings of the Royal Society B: Biological Sciences |
container_volume |
291 |
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2015 |
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1790608788943798272 |