Salmo salar Skin and Gill Microbiome during Piscirickettsia salmonis Infection

• Published in: Animals
• Main Authors: Godoy, Marcos, Coca, Yoandy, Suárez, Rudy, Montes de Oca, Marco, Bledsoe, Jacob W., Burbulis, Ian, Caro, Diego, Pontigo, Juan Pablo, Maracaja-Coutinho, Vinicius, Arias-Carrasco, Raúl, Rodríguez-Córdova, Leonardo, Sáez-Navarrete, César
• Format: Text
• Language: English
• Published: MDPI 2023
• Subjects: Article; Atlantic salmon; Salmo salar
• Online Access: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10778177/; http://www.ncbi.nlm.nih.gov/pubmed/38200828; https://doi.org/10.3390/ani14010097

SIMPLE SUMMARY: Farmed Atlantic salmon are routinely exposed to bacterial pathogens, e.g., Piscirickettsia salmonis. Infection by Piscirickettsia sp. leads to a complex array of skin ulcers that can be difficult to treat and increases susceptibility to opportunistic infections. Evidence indicates that bacterial networks residing on salmon skin protect against developing ulcers by excluding pathogen colonization. A collapse of these beneficial interactions is thought to promote susceptibility to pathogen colonization during early stages of infection. We characterized the types and abundances of bacterial constituents on the skin of healthy Atlantic salmon compared with fish suffering from P. salmonis infection to test this hypothesis. The knowledge we gained can be used to optimize methods for early detection and prevention of skin ulcers by disrupting cooperative interactions between pathogenic bacteria. ABSTRACT: Maintaining the high overall health of farmed animals is a central tenant of their well-being and care. Intense animal crowding in aquaculture promotes animal morbidity especially in the absence of straightforward methods for monitoring their health. Here, we used bacterial 16S ribosomal RNA gene sequencing to measure bacterial population dynamics during P. salmonis infection. We observed a complex bacterial community consisting of a previously undescribed core pathobiome. Notably, we detected Aliivibrio wodanis and Tenacibaculum dicentrarchi on the skin ulcers of salmon infected with P. salmonis, while Vibrio spp. were enriched on infected gills. The prevalence of these co-occurring networks indicated that coinfection with other pathogens may enhance P. salmonis pathogenicity.