A population-based analysis of the epidemiology of penile cancer in Newfoundland and Labrador
INTRODUCTION: Penile cancers are a rare subset of carcinomas accounting for <1% of all diagnosed malignancies. There have been recent reports of increasing incidence globally; however, there is limited Canadian literature pertaining to these neoplasms. The province of Newfoundland and Labrador (N...
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ftpubmed:oai:pubmedcentral.nih.gov:10766332 2024-02-04T10:02:11+01:00 A population-based analysis of the epidemiology of penile cancer in Newfoundland and Labrador Janes, W.C. Ian Johnston, Paul H. 2024-01 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10766332/ http://www.ncbi.nlm.nih.gov/pubmed/37812793 https://doi.org/10.5489/cuaj.8451 en eng Canadian Medical Association http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10766332/ http://www.ncbi.nlm.nih.gov/pubmed/37812793 http://dx.doi.org/10.5489/cuaj.8451 Copyright: © 2024 Canadian Urological Association or its licensors Can Urol Assoc J Original Research Text 2024 ftpubmed https://doi.org/10.5489/cuaj.8451 2024-01-07T02:09:35Z INTRODUCTION: Penile cancers are a rare subset of carcinomas accounting for <1% of all diagnosed malignancies. There have been recent reports of increasing incidence globally; however, there is limited Canadian literature pertaining to these neoplasms. The province of Newfoundland and Labrador (NL ) represents an important entity to study, possessing the highest national incidence of cancer, along with a plethora of relevant risk factors for penile cancer. METHODS: A retrospective chart analysis of all patients with a diagnosis of penile cancer in NL between the years of 2006 and 2018 was conducted. The main outcomes included overall incidence, proportion with metastatic disease, tumor demographics, and overall survival (OS ). Incidence among the male population was calculated using Statistics Canada annual reports. RESULTS: An identified 81 cases satisfied the inclusion criteria, with a median age at diagnosis of 65 (interquartile range 20) years. Crude incidence of penile cancer ranged from 1.20–4.27/100 000 males in 2007 and 2010, respectively, while the average age-standardized incidence was 2.34/100 000 males across the study timeframe. Metastatic disease was noted in 17 (21.0%) patients, with a five-year OS of 74% for all penile malignancies, decreasing to 66% in those with invasive squamous cell carcinoma. CONCLUSIONS: The incidence of penile cancer in our population was higher than reported Western jurisdictions and showed frequent rates of metastatic spread. These observations are likely multifactorial, resultant of chronic inflammation paired with high rates of modifiable risk factors and diagnostic delays. An evident need for greater examination and improved reporting of these malignancies in the province was identified. Text Newfoundland PubMed Central (PMC) Newfoundland Canada Canadian Urological Association Journal 18 1 |
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Original Research Janes, W.C. Ian Johnston, Paul H. A population-based analysis of the epidemiology of penile cancer in Newfoundland and Labrador |
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Original Research |
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INTRODUCTION: Penile cancers are a rare subset of carcinomas accounting for <1% of all diagnosed malignancies. There have been recent reports of increasing incidence globally; however, there is limited Canadian literature pertaining to these neoplasms. The province of Newfoundland and Labrador (NL ) represents an important entity to study, possessing the highest national incidence of cancer, along with a plethora of relevant risk factors for penile cancer. METHODS: A retrospective chart analysis of all patients with a diagnosis of penile cancer in NL between the years of 2006 and 2018 was conducted. The main outcomes included overall incidence, proportion with metastatic disease, tumor demographics, and overall survival (OS ). Incidence among the male population was calculated using Statistics Canada annual reports. RESULTS: An identified 81 cases satisfied the inclusion criteria, with a median age at diagnosis of 65 (interquartile range 20) years. Crude incidence of penile cancer ranged from 1.20–4.27/100 000 males in 2007 and 2010, respectively, while the average age-standardized incidence was 2.34/100 000 males across the study timeframe. Metastatic disease was noted in 17 (21.0%) patients, with a five-year OS of 74% for all penile malignancies, decreasing to 66% in those with invasive squamous cell carcinoma. CONCLUSIONS: The incidence of penile cancer in our population was higher than reported Western jurisdictions and showed frequent rates of metastatic spread. These observations are likely multifactorial, resultant of chronic inflammation paired with high rates of modifiable risk factors and diagnostic delays. An evident need for greater examination and improved reporting of these malignancies in the province was identified. |
format |
Text |
author |
Janes, W.C. Ian Johnston, Paul H. |
author_facet |
Janes, W.C. Ian Johnston, Paul H. |
author_sort |
Janes, W.C. Ian |
title |
A population-based analysis of the epidemiology of penile cancer in Newfoundland and Labrador |
title_short |
A population-based analysis of the epidemiology of penile cancer in Newfoundland and Labrador |
title_full |
A population-based analysis of the epidemiology of penile cancer in Newfoundland and Labrador |
title_fullStr |
A population-based analysis of the epidemiology of penile cancer in Newfoundland and Labrador |
title_full_unstemmed |
A population-based analysis of the epidemiology of penile cancer in Newfoundland and Labrador |
title_sort |
population-based analysis of the epidemiology of penile cancer in newfoundland and labrador |
publisher |
Canadian Medical Association |
publishDate |
2024 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10766332/ http://www.ncbi.nlm.nih.gov/pubmed/37812793 https://doi.org/10.5489/cuaj.8451 |
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Newfoundland Canada |
geographic_facet |
Newfoundland Canada |
genre |
Newfoundland |
genre_facet |
Newfoundland |
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Can Urol Assoc J |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10766332/ http://www.ncbi.nlm.nih.gov/pubmed/37812793 http://dx.doi.org/10.5489/cuaj.8451 |
op_rights |
Copyright: © 2024 Canadian Urological Association or its licensors |
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https://doi.org/10.5489/cuaj.8451 |
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Canadian Urological Association Journal |
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18 |
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1 |
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