Population-based birth cohort study on diabetes in pregnancy and infant hospitalisations in Cree, other First Nations and non-Indigenous communities in Quebec
OBJECTIVES: Diabetes in pregnancy, whether pre-gestational (chronic) or gestational (de novo hyperglycaemia), increases the risk of adverse birth outcomes. It is unclear whether gestational diabetes increases the risk of postnatal morbidity in infants. Cree First Nations in Quebec are at high risk f...
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Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10693854/ http://www.ncbi.nlm.nih.gov/pubmed/38040430 https://doi.org/10.1136/bmjopen-2023-074518 |
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ftpubmed:oai:pubmedcentral.nih.gov:10693854 2024-01-07T09:43:14+01:00 Population-based birth cohort study on diabetes in pregnancy and infant hospitalisations in Cree, other First Nations and non-Indigenous communities in Quebec Huang, Rong Xiao, Lin Zhu, Jane Cheng, Justin Torrie, Jill McHugh, Nancy Gros-Louis Auger, Nathalie Luo, Zhong-Cheng 2023-12-01 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10693854/ http://www.ncbi.nlm.nih.gov/pubmed/38040430 https://doi.org/10.1136/bmjopen-2023-074518 en eng BMJ Publishing Group http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10693854/ http://www.ncbi.nlm.nih.gov/pubmed/38040430 http://dx.doi.org/10.1136/bmjopen-2023-074518 © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) . BMJ Open Epidemiology Text 2023 ftpubmed https://doi.org/10.1136/bmjopen-2023-074518 2023-12-10T01:45:47Z OBJECTIVES: Diabetes in pregnancy, whether pre-gestational (chronic) or gestational (de novo hyperglycaemia), increases the risk of adverse birth outcomes. It is unclear whether gestational diabetes increases the risk of postnatal morbidity in infants. Cree First Nations in Quebec are at high risk for diabetes in pregnancy. We assessed whether pre-gestational or gestational diabetes may increase infant hospitalisation (an infant morbidity indicator) incidence, and whether this may be related to more frequent infant hospitalisations in Cree and other First Nations in Quebec. DESIGN: Population-based birth cohort study through administrative health data linkage. SETTING AND PARTICIPANTS: Singleton infants (≤1 year) born to mothers in Cree (n=5070), other First Nations (9910) and non-Indigenous (48 200) communities in rural Quebec. RESULTS: Both diabetes in pregnancy and infant hospitalisation rates were much higher comparing Cree (23.7% and 29.0%) and other First Nations (12.4% and 34.1%) to non-Indigenous (5.9% and 15.5%) communities. Compared with non-diabetes, pre-gestational diabetes was associated with an increased risk of any infant hospitalisation to a greater extent in Cree and other First Nations (relative risk (RR) 1.56 (95% CI 1.28 to 1.91)) than non-Indigenous (RR 1.26 (1.15 to 1.39)) communities. Pre-gestational diabetes was associated with increased risks of infant hospitalisation due to diseases of multiple systems in all communities. There were no significant associations between gestational diabetes and risks of infant hospitalisation in all communities. The population attributable risk fraction of infant hospitalisations (overall) for pre-gestational diabetes was 6.2% in Cree, 1.6% in other First Nations and 0.3% in non-Indigenous communities. CONCLUSIONS: The study is the first to demonstrate that pre-gestational diabetes increases the risk of infant hospitalisation overall and due to diseases of multiple systems, but gestational diabetes does not. High prevalence of pre-gestational diabetes may ... Text First Nations PubMed Central (PMC) BMJ Open 13 12 e074518 |
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Epidemiology |
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Epidemiology Huang, Rong Xiao, Lin Zhu, Jane Cheng, Justin Torrie, Jill McHugh, Nancy Gros-Louis Auger, Nathalie Luo, Zhong-Cheng Population-based birth cohort study on diabetes in pregnancy and infant hospitalisations in Cree, other First Nations and non-Indigenous communities in Quebec |
topic_facet |
Epidemiology |
description |
OBJECTIVES: Diabetes in pregnancy, whether pre-gestational (chronic) or gestational (de novo hyperglycaemia), increases the risk of adverse birth outcomes. It is unclear whether gestational diabetes increases the risk of postnatal morbidity in infants. Cree First Nations in Quebec are at high risk for diabetes in pregnancy. We assessed whether pre-gestational or gestational diabetes may increase infant hospitalisation (an infant morbidity indicator) incidence, and whether this may be related to more frequent infant hospitalisations in Cree and other First Nations in Quebec. DESIGN: Population-based birth cohort study through administrative health data linkage. SETTING AND PARTICIPANTS: Singleton infants (≤1 year) born to mothers in Cree (n=5070), other First Nations (9910) and non-Indigenous (48 200) communities in rural Quebec. RESULTS: Both diabetes in pregnancy and infant hospitalisation rates were much higher comparing Cree (23.7% and 29.0%) and other First Nations (12.4% and 34.1%) to non-Indigenous (5.9% and 15.5%) communities. Compared with non-diabetes, pre-gestational diabetes was associated with an increased risk of any infant hospitalisation to a greater extent in Cree and other First Nations (relative risk (RR) 1.56 (95% CI 1.28 to 1.91)) than non-Indigenous (RR 1.26 (1.15 to 1.39)) communities. Pre-gestational diabetes was associated with increased risks of infant hospitalisation due to diseases of multiple systems in all communities. There were no significant associations between gestational diabetes and risks of infant hospitalisation in all communities. The population attributable risk fraction of infant hospitalisations (overall) for pre-gestational diabetes was 6.2% in Cree, 1.6% in other First Nations and 0.3% in non-Indigenous communities. CONCLUSIONS: The study is the first to demonstrate that pre-gestational diabetes increases the risk of infant hospitalisation overall and due to diseases of multiple systems, but gestational diabetes does not. High prevalence of pre-gestational diabetes may ... |
format |
Text |
author |
Huang, Rong Xiao, Lin Zhu, Jane Cheng, Justin Torrie, Jill McHugh, Nancy Gros-Louis Auger, Nathalie Luo, Zhong-Cheng |
author_facet |
Huang, Rong Xiao, Lin Zhu, Jane Cheng, Justin Torrie, Jill McHugh, Nancy Gros-Louis Auger, Nathalie Luo, Zhong-Cheng |
author_sort |
Huang, Rong |
title |
Population-based birth cohort study on diabetes in pregnancy and infant hospitalisations in Cree, other First Nations and non-Indigenous communities in Quebec |
title_short |
Population-based birth cohort study on diabetes in pregnancy and infant hospitalisations in Cree, other First Nations and non-Indigenous communities in Quebec |
title_full |
Population-based birth cohort study on diabetes in pregnancy and infant hospitalisations in Cree, other First Nations and non-Indigenous communities in Quebec |
title_fullStr |
Population-based birth cohort study on diabetes in pregnancy and infant hospitalisations in Cree, other First Nations and non-Indigenous communities in Quebec |
title_full_unstemmed |
Population-based birth cohort study on diabetes in pregnancy and infant hospitalisations in Cree, other First Nations and non-Indigenous communities in Quebec |
title_sort |
population-based birth cohort study on diabetes in pregnancy and infant hospitalisations in cree, other first nations and non-indigenous communities in quebec |
publisher |
BMJ Publishing Group |
publishDate |
2023 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10693854/ http://www.ncbi.nlm.nih.gov/pubmed/38040430 https://doi.org/10.1136/bmjopen-2023-074518 |
genre |
First Nations |
genre_facet |
First Nations |
op_source |
BMJ Open |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10693854/ http://www.ncbi.nlm.nih.gov/pubmed/38040430 http://dx.doi.org/10.1136/bmjopen-2023-074518 |
op_rights |
© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) . |
op_doi |
https://doi.org/10.1136/bmjopen-2023-074518 |
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BMJ Open |
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13 |
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12 |
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e074518 |
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