Vitamin D receptor expression in hydatidiform mole and gestational trophoblastic neoplasia: A cross-sectional study
OBJECTIVE: Vitamin D receptor (VDR) exerts anti-cancer properties in a variety of cancers. The purpose of this study was to investigate the expression of VDR in patients with hydatidiform mole (HM) and gestational trophoblastic neoplasia (GTN). METHODS: This is a cross-sectional study involved 61 sp...
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Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692753/ http://www.ncbi.nlm.nih.gov/pubmed/38047239 https://doi.org/10.1016/j.jtumed.2023.09.006 |
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ftpubmed:oai:pubmedcentral.nih.gov:10692753 2024-01-07T09:43:44+01:00 Vitamin D receptor expression in hydatidiform mole and gestational trophoblastic neoplasia: A cross-sectional study Sasotya, RM Sonny Kustiandi, Arieff Hidayat, Yudi Mulyana Effendi, Jusuf Sulaeman Permadi, Wiryawan Harsono, Ali Budi Mulyantari, Ayu Insafi Hernowo, Bethy S. 2023-10-07 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692753/ http://www.ncbi.nlm.nih.gov/pubmed/38047239 https://doi.org/10.1016/j.jtumed.2023.09.006 en eng Taibah University http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692753/ http://www.ncbi.nlm.nih.gov/pubmed/38047239 http://dx.doi.org/10.1016/j.jtumed.2023.09.006 © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). J Taibah Univ Med Sci Original Article Text 2023 ftpubmed https://doi.org/10.1016/j.jtumed.2023.09.006 2023-12-10T01:43:29Z OBJECTIVE: Vitamin D receptor (VDR) exerts anti-cancer properties in a variety of cancers. The purpose of this study was to investigate the expression of VDR in patients with hydatidiform mole (HM) and gestational trophoblastic neoplasia (GTN). METHODS: This is a cross-sectional study involved 61 specimens of HM (n = 37, 60.7%) and GTN (n = 24, 39.3%) was collected from the biopsy. An immunohistochemistry was used to asses the VDR expression. Student's t-test and Mann–Whitney test were used to compare the expression of VDR, including VDR staining intensity, VDR distribution, and histoscore, between HM and GTN tissue specimens. RESULTS: No significant differences in age and parity were noted between patients with HM or GTN (p > 0.05). The VDR staining intensity of GTN tissue specimens was significantly lower than that of HM tissue specimens (2.3 ± 0.8 vs. 2.8 ± 0.5, p = 0.008). In addition, the histoscore for GTN tissues was significantly lower than that for HM tissues (7.3 ± 3.2 vs. 9.4 ± 28, p = 0.016). However, no significant differences in VDR distribution between GTN and HM tissues were observed (3.3 ± 0.8 vs. 3.3 ± 1.0, p = 0.525). CONCLUSION: Low VDR expression is associated with GTN, whereas high VDR expression is associated with HM, suggesting that the expression of VDR may regulate the severity of gestational trophoblastic disease. Text GTN-P PubMed Central (PMC) Journal of Taibah University Medical Sciences 19 1 184 189 |
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Original Article Sasotya, RM Sonny Kustiandi, Arieff Hidayat, Yudi Mulyana Effendi, Jusuf Sulaeman Permadi, Wiryawan Harsono, Ali Budi Mulyantari, Ayu Insafi Hernowo, Bethy S. Vitamin D receptor expression in hydatidiform mole and gestational trophoblastic neoplasia: A cross-sectional study |
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Original Article |
description |
OBJECTIVE: Vitamin D receptor (VDR) exerts anti-cancer properties in a variety of cancers. The purpose of this study was to investigate the expression of VDR in patients with hydatidiform mole (HM) and gestational trophoblastic neoplasia (GTN). METHODS: This is a cross-sectional study involved 61 specimens of HM (n = 37, 60.7%) and GTN (n = 24, 39.3%) was collected from the biopsy. An immunohistochemistry was used to asses the VDR expression. Student's t-test and Mann–Whitney test were used to compare the expression of VDR, including VDR staining intensity, VDR distribution, and histoscore, between HM and GTN tissue specimens. RESULTS: No significant differences in age and parity were noted between patients with HM or GTN (p > 0.05). The VDR staining intensity of GTN tissue specimens was significantly lower than that of HM tissue specimens (2.3 ± 0.8 vs. 2.8 ± 0.5, p = 0.008). In addition, the histoscore for GTN tissues was significantly lower than that for HM tissues (7.3 ± 3.2 vs. 9.4 ± 28, p = 0.016). However, no significant differences in VDR distribution between GTN and HM tissues were observed (3.3 ± 0.8 vs. 3.3 ± 1.0, p = 0.525). CONCLUSION: Low VDR expression is associated with GTN, whereas high VDR expression is associated with HM, suggesting that the expression of VDR may regulate the severity of gestational trophoblastic disease. |
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Text |
author |
Sasotya, RM Sonny Kustiandi, Arieff Hidayat, Yudi Mulyana Effendi, Jusuf Sulaeman Permadi, Wiryawan Harsono, Ali Budi Mulyantari, Ayu Insafi Hernowo, Bethy S. |
author_facet |
Sasotya, RM Sonny Kustiandi, Arieff Hidayat, Yudi Mulyana Effendi, Jusuf Sulaeman Permadi, Wiryawan Harsono, Ali Budi Mulyantari, Ayu Insafi Hernowo, Bethy S. |
author_sort |
Sasotya, RM Sonny |
title |
Vitamin D receptor expression in hydatidiform mole and gestational trophoblastic neoplasia: A cross-sectional study |
title_short |
Vitamin D receptor expression in hydatidiform mole and gestational trophoblastic neoplasia: A cross-sectional study |
title_full |
Vitamin D receptor expression in hydatidiform mole and gestational trophoblastic neoplasia: A cross-sectional study |
title_fullStr |
Vitamin D receptor expression in hydatidiform mole and gestational trophoblastic neoplasia: A cross-sectional study |
title_full_unstemmed |
Vitamin D receptor expression in hydatidiform mole and gestational trophoblastic neoplasia: A cross-sectional study |
title_sort |
vitamin d receptor expression in hydatidiform mole and gestational trophoblastic neoplasia: a cross-sectional study |
publisher |
Taibah University |
publishDate |
2023 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692753/ http://www.ncbi.nlm.nih.gov/pubmed/38047239 https://doi.org/10.1016/j.jtumed.2023.09.006 |
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GTN-P |
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GTN-P |
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J Taibah Univ Med Sci |
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10692753/ http://www.ncbi.nlm.nih.gov/pubmed/38047239 http://dx.doi.org/10.1016/j.jtumed.2023.09.006 |
op_rights |
© 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
op_doi |
https://doi.org/10.1016/j.jtumed.2023.09.006 |
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Journal of Taibah University Medical Sciences |
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19 |
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1 |
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184 |
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189 |
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1787425016246173696 |