A diet containing cod backbone proteins attenuated the development of mesangial sclerosis and tubular dysfunction in male obese BTBR ob/ob mice
PURPOSE: The obese black and tan, brachyuric (BTBR) ob/ob mouse spontaneously develops features comparable to human diabetic nephropathy. The primary aim of the present study was to investigate if a diet containing fish proteins would attenuate or delay the development of glomerular hypertrophy (glo...
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ftpubmed:oai:pubmedcentral.nih.gov:10611847 2023-12-03T10:19:03+01:00 A diet containing cod backbone proteins attenuated the development of mesangial sclerosis and tubular dysfunction in male obese BTBR ob/ob mice O’Keeffe, Maria Oterhals, Åge Weishaupt, Hrafn Leh, Sabine Ulvik, Arve Ueland, Per Magne Halstensen, Alfred Marti, Hans-Peter Gudbrandsen, Oddrun Anita 2023-08-07 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10611847/ http://www.ncbi.nlm.nih.gov/pubmed/37550593 https://doi.org/10.1007/s00394-023-03227-4 en eng Springer Berlin Heidelberg http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10611847/ http://www.ncbi.nlm.nih.gov/pubmed/37550593 http://dx.doi.org/10.1007/s00394-023-03227-4 © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . Eur J Nutr Original Contribution Text 2023 ftpubmed https://doi.org/10.1007/s00394-023-03227-4 2023-11-05T01:58:16Z PURPOSE: The obese black and tan, brachyuric (BTBR) ob/ob mouse spontaneously develops features comparable to human diabetic nephropathy. The primary aim of the present study was to investigate if a diet containing fish proteins would attenuate or delay the development of glomerular hypertrophy (glomerulomegaly), mesangial sclerosis and albuminuria in obese BTBR ob/ob mice. METHODS: Obese BTBR.CgLep(ob)/WiscJ male mice were fed diets containing 25% of protein from Atlantic cod backbones and 75% of protein from casein (Cod-BB group), or casein as the sole protein source (control group). Kidneys were analysed morphologically, and markers for renal dysfunction were analysed biochemically in urine and serum. RESULTS: The Cod-BB diet attenuated the development of mesangial sclerosis (P 0.040) without affecting the development of glomerular hypertrophy and albuminuria. The urine concentration of cystatin C (relative to creatinine) was lower in mice fed the Cod-BB diet (P 0.0044). CONCLUSION: A diet containing cod backbone protein powder attenuated the development of mesangial sclerosis and tubular dysfunction in obese BTBR ob/ob mice, but did not prevent the development of glomerular hypertrophy and albuminuria in these mice. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00394-023-03227-4. Text atlantic cod PubMed Central (PMC) European Journal of Nutrition 62 8 3227 3240 |
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Original Contribution |
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Original Contribution O’Keeffe, Maria Oterhals, Åge Weishaupt, Hrafn Leh, Sabine Ulvik, Arve Ueland, Per Magne Halstensen, Alfred Marti, Hans-Peter Gudbrandsen, Oddrun Anita A diet containing cod backbone proteins attenuated the development of mesangial sclerosis and tubular dysfunction in male obese BTBR ob/ob mice |
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Original Contribution |
description |
PURPOSE: The obese black and tan, brachyuric (BTBR) ob/ob mouse spontaneously develops features comparable to human diabetic nephropathy. The primary aim of the present study was to investigate if a diet containing fish proteins would attenuate or delay the development of glomerular hypertrophy (glomerulomegaly), mesangial sclerosis and albuminuria in obese BTBR ob/ob mice. METHODS: Obese BTBR.CgLep(ob)/WiscJ male mice were fed diets containing 25% of protein from Atlantic cod backbones and 75% of protein from casein (Cod-BB group), or casein as the sole protein source (control group). Kidneys were analysed morphologically, and markers for renal dysfunction were analysed biochemically in urine and serum. RESULTS: The Cod-BB diet attenuated the development of mesangial sclerosis (P 0.040) without affecting the development of glomerular hypertrophy and albuminuria. The urine concentration of cystatin C (relative to creatinine) was lower in mice fed the Cod-BB diet (P 0.0044). CONCLUSION: A diet containing cod backbone protein powder attenuated the development of mesangial sclerosis and tubular dysfunction in obese BTBR ob/ob mice, but did not prevent the development of glomerular hypertrophy and albuminuria in these mice. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00394-023-03227-4. |
format |
Text |
author |
O’Keeffe, Maria Oterhals, Åge Weishaupt, Hrafn Leh, Sabine Ulvik, Arve Ueland, Per Magne Halstensen, Alfred Marti, Hans-Peter Gudbrandsen, Oddrun Anita |
author_facet |
O’Keeffe, Maria Oterhals, Åge Weishaupt, Hrafn Leh, Sabine Ulvik, Arve Ueland, Per Magne Halstensen, Alfred Marti, Hans-Peter Gudbrandsen, Oddrun Anita |
author_sort |
O’Keeffe, Maria |
title |
A diet containing cod backbone proteins attenuated the development of mesangial sclerosis and tubular dysfunction in male obese BTBR ob/ob mice |
title_short |
A diet containing cod backbone proteins attenuated the development of mesangial sclerosis and tubular dysfunction in male obese BTBR ob/ob mice |
title_full |
A diet containing cod backbone proteins attenuated the development of mesangial sclerosis and tubular dysfunction in male obese BTBR ob/ob mice |
title_fullStr |
A diet containing cod backbone proteins attenuated the development of mesangial sclerosis and tubular dysfunction in male obese BTBR ob/ob mice |
title_full_unstemmed |
A diet containing cod backbone proteins attenuated the development of mesangial sclerosis and tubular dysfunction in male obese BTBR ob/ob mice |
title_sort |
diet containing cod backbone proteins attenuated the development of mesangial sclerosis and tubular dysfunction in male obese btbr ob/ob mice |
publisher |
Springer Berlin Heidelberg |
publishDate |
2023 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10611847/ http://www.ncbi.nlm.nih.gov/pubmed/37550593 https://doi.org/10.1007/s00394-023-03227-4 |
genre |
atlantic cod |
genre_facet |
atlantic cod |
op_source |
Eur J Nutr |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10611847/ http://www.ncbi.nlm.nih.gov/pubmed/37550593 http://dx.doi.org/10.1007/s00394-023-03227-4 |
op_rights |
© The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
op_doi |
https://doi.org/10.1007/s00394-023-03227-4 |
container_title |
European Journal of Nutrition |
container_volume |
62 |
container_issue |
8 |
container_start_page |
3227 |
op_container_end_page |
3240 |
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1784266194265571328 |