A diet containing cod backbone proteins attenuated the development of mesangial sclerosis and tubular dysfunction in male obese BTBR ob/ob mice

PURPOSE: The obese black and tan, brachyuric (BTBR) ob/ob mouse spontaneously develops features comparable to human diabetic nephropathy. The primary aim of the present study was to investigate if a diet containing fish proteins would attenuate or delay the development of glomerular hypertrophy (glo...

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Bibliographic Details
Published in:European Journal of Nutrition
Main Authors: O’Keeffe, Maria, Oterhals, Åge, Weishaupt, Hrafn, Leh, Sabine, Ulvik, Arve, Ueland, Per Magne, Halstensen, Alfred, Marti, Hans-Peter, Gudbrandsen, Oddrun Anita
Format: Text
Language:English
Published: Springer Berlin Heidelberg 2023
Subjects:
Original Contribution
atlantic cod
Online Access:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10611847/
http://www.ncbi.nlm.nih.gov/pubmed/37550593
https://doi.org/10.1007/s00394-023-03227-4
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Summary:PURPOSE: The obese black and tan, brachyuric (BTBR) ob/ob mouse spontaneously develops features comparable to human diabetic nephropathy. The primary aim of the present study was to investigate if a diet containing fish proteins would attenuate or delay the development of glomerular hypertrophy (glomerulomegaly), mesangial sclerosis and albuminuria in obese BTBR ob/ob mice. METHODS: Obese BTBR.CgLep(ob)/WiscJ male mice were fed diets containing 25% of protein from Atlantic cod backbones and 75% of protein from casein (Cod-BB group), or casein as the sole protein source (control group). Kidneys were analysed morphologically, and markers for renal dysfunction were analysed biochemically in urine and serum. RESULTS: The Cod-BB diet attenuated the development of mesangial sclerosis (P 0.040) without affecting the development of glomerular hypertrophy and albuminuria. The urine concentration of cystatin C (relative to creatinine) was lower in mice fed the Cod-BB diet (P 0.0044). CONCLUSION: A diet containing cod backbone protein powder attenuated the development of mesangial sclerosis and tubular dysfunction in obese BTBR ob/ob mice, but did not prevent the development of glomerular hypertrophy and albuminuria in these mice. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00394-023-03227-4.

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