Adherence to oral antiretroviral therapy in Canada, 2010–2020
OBJECTIVE: To assess antiretroviral therapy (ART) adherence among people with HIV (PWH) in Canada and identify baseline characteristics associated with suboptimal adherence (<95%). DESIGN: Retrospective observational study using data from the National Prescription Drug Utilization Information Sys...
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ftpubmed:oai:pubmedcentral.nih.gov:10552836 2023-11-05T03:43:34+01:00 Adherence to oral antiretroviral therapy in Canada, 2010–2020 Angel, Jonathan B. Freilich, Jonatan Arthurs, Erin Ban, Joann K. Lachaine, Jean Chounta, Vasiliki Harris, Marianne 2023-11-01 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10552836/ http://www.ncbi.nlm.nih.gov/pubmed/37418513 https://doi.org/10.1097/QAD.0000000000003648 en eng Lippincott Williams & Wilkins http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10552836/ http://www.ncbi.nlm.nih.gov/pubmed/37418513 http://dx.doi.org/10.1097/QAD.0000000000003648 Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) AIDS Epidemiology and Social Text 2023 ftpubmed https://doi.org/10.1097/QAD.0000000000003648 2023-10-08T01:16:52Z OBJECTIVE: To assess antiretroviral therapy (ART) adherence among people with HIV (PWH) in Canada and identify baseline characteristics associated with suboptimal adherence (<95%). DESIGN: Retrospective observational study using data from the National Prescription Drug Utilization Information System and Régie de l’assurance maladie Quebec (RAMQ) Public Prescription Drug Insurance Plan. METHODS: This analysis included PWH aged 18 years or older who initiated an ART regimen and were followed for at least 12 months (2010–2020). Patient characteristics were summarized using medical/pharmacy claims data from seven provinces (Alberta, Manitoba, New Brunswick, Newfoundland and Labrador, Ontario, Saskatchewan, and Quebec). ART regimen at index date (first dispensing of a regimen including a core agent) was defined as a single-tablet or multitablet regimen (MTR). Adherence was calculated using a Proportion of Days Covered approach, based on ART dispensing, recorded between April 2010 and the last available date. Multivariate linear regression analysis was used to determine correlations between suboptimal adherence and baseline characteristics. RESULTS: We identified 19 322 eligible PWH, 44.7% of whom had suboptimal adherence (<95%). Among 12 594 PWH with evaluable baseline data, 10 673 (84.8%) were ART-naive, 74.2% were men, mean age was 42.9 years, and 54.1% received a MTR as their ART. Based on multivariate regression analysis, suboptimal adherence was significantly associated with multitablet ART (P < 0.001) and younger age (P < 0.001) but not sex. CONCLUSION: Almost half of adult PWH in Canada had suboptimal adherence to ART. Better understanding of factors influencing adherence may help address gaps in current care practices that may impact adherence. Text Newfoundland PubMed Central (PMC) AIDS 37 13 2031 2040 |
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Epidemiology and Social |
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Epidemiology and Social Angel, Jonathan B. Freilich, Jonatan Arthurs, Erin Ban, Joann K. Lachaine, Jean Chounta, Vasiliki Harris, Marianne Adherence to oral antiretroviral therapy in Canada, 2010–2020 |
topic_facet |
Epidemiology and Social |
description |
OBJECTIVE: To assess antiretroviral therapy (ART) adherence among people with HIV (PWH) in Canada and identify baseline characteristics associated with suboptimal adherence (<95%). DESIGN: Retrospective observational study using data from the National Prescription Drug Utilization Information System and Régie de l’assurance maladie Quebec (RAMQ) Public Prescription Drug Insurance Plan. METHODS: This analysis included PWH aged 18 years or older who initiated an ART regimen and were followed for at least 12 months (2010–2020). Patient characteristics were summarized using medical/pharmacy claims data from seven provinces (Alberta, Manitoba, New Brunswick, Newfoundland and Labrador, Ontario, Saskatchewan, and Quebec). ART regimen at index date (first dispensing of a regimen including a core agent) was defined as a single-tablet or multitablet regimen (MTR). Adherence was calculated using a Proportion of Days Covered approach, based on ART dispensing, recorded between April 2010 and the last available date. Multivariate linear regression analysis was used to determine correlations between suboptimal adherence and baseline characteristics. RESULTS: We identified 19 322 eligible PWH, 44.7% of whom had suboptimal adherence (<95%). Among 12 594 PWH with evaluable baseline data, 10 673 (84.8%) were ART-naive, 74.2% were men, mean age was 42.9 years, and 54.1% received a MTR as their ART. Based on multivariate regression analysis, suboptimal adherence was significantly associated with multitablet ART (P < 0.001) and younger age (P < 0.001) but not sex. CONCLUSION: Almost half of adult PWH in Canada had suboptimal adherence to ART. Better understanding of factors influencing adherence may help address gaps in current care practices that may impact adherence. |
format |
Text |
author |
Angel, Jonathan B. Freilich, Jonatan Arthurs, Erin Ban, Joann K. Lachaine, Jean Chounta, Vasiliki Harris, Marianne |
author_facet |
Angel, Jonathan B. Freilich, Jonatan Arthurs, Erin Ban, Joann K. Lachaine, Jean Chounta, Vasiliki Harris, Marianne |
author_sort |
Angel, Jonathan B. |
title |
Adherence to oral antiretroviral therapy in Canada, 2010–2020 |
title_short |
Adherence to oral antiretroviral therapy in Canada, 2010–2020 |
title_full |
Adherence to oral antiretroviral therapy in Canada, 2010–2020 |
title_fullStr |
Adherence to oral antiretroviral therapy in Canada, 2010–2020 |
title_full_unstemmed |
Adherence to oral antiretroviral therapy in Canada, 2010–2020 |
title_sort |
adherence to oral antiretroviral therapy in canada, 2010–2020 |
publisher |
Lippincott Williams & Wilkins |
publishDate |
2023 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10552836/ http://www.ncbi.nlm.nih.gov/pubmed/37418513 https://doi.org/10.1097/QAD.0000000000003648 |
genre |
Newfoundland |
genre_facet |
Newfoundland |
op_source |
AIDS |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10552836/ http://www.ncbi.nlm.nih.gov/pubmed/37418513 http://dx.doi.org/10.1097/QAD.0000000000003648 |
op_rights |
Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) |
op_doi |
https://doi.org/10.1097/QAD.0000000000003648 |
container_title |
AIDS |
container_volume |
37 |
container_issue |
13 |
container_start_page |
2031 |
op_container_end_page |
2040 |
_version_ |
1781702103673077760 |