Association of pre-diagnostic physical exercise and peri-diagnostic body composition with mortality in non-metastatic colorectal cancer
PURPOSE: Sarcopenia and myosteatosis, quantified via computed tomography (CT), are associated with poor colorectal cancer outcomes. These body composition estimates can be influenced by physical exercise. We explored the correlation between pre-diagnostic physical exercise, body composition close to...
Published in: | International Journal of Colorectal Disease |
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Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10533590/ http://www.ncbi.nlm.nih.gov/pubmed/37755537 https://doi.org/10.1007/s00384-023-04536-0 |
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ftpubmed:oai:pubmedcentral.nih.gov:10533590 2023-10-29T02:38:59+01:00 Association of pre-diagnostic physical exercise and peri-diagnostic body composition with mortality in non-metastatic colorectal cancer Renman, David van Guelpen, Bethany Anderson, Fredrick Axelsson, Jan Riklund, Katrine Strigård, Karin Palmqvist, Richard Gunnarsson, Ulf Gylling, Björn 2023-09-27 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10533590/ http://www.ncbi.nlm.nih.gov/pubmed/37755537 https://doi.org/10.1007/s00384-023-04536-0 en eng Springer Berlin Heidelberg http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10533590/ http://www.ncbi.nlm.nih.gov/pubmed/37755537 http://dx.doi.org/10.1007/s00384-023-04536-0 © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . Int J Colorectal Dis Research Text 2023 ftpubmed https://doi.org/10.1007/s00384-023-04536-0 2023-10-01T01:17:08Z PURPOSE: Sarcopenia and myosteatosis, quantified via computed tomography (CT), are associated with poor colorectal cancer outcomes. These body composition estimates can be influenced by physical exercise. We explored the correlation between pre-diagnostic physical exercise, body composition close to diagnosis, and the combined prognosis impact of these factors. METHODS: We studied 519 stage I–III colorectal cancer (CRC) cases diagnosed 2000–2016 with pre-diagnostic self-reported recreational physical exercise data collected in the prospective, population-based Northern Sweden Health and Disease Study, and CT-estimated skeletal muscle index (SMI) or skeletal muscle density (SMD). Risk estimates were calculated by multivariable logistic regression and Cox proportional hazards models. RESULTS: No association was seen between low pre-diagnostic physical exercise and sarcopenia/myosteatosis in the multivariable model adjusted for age, sex, educational level, tumor stage, and tumor location. In multivariable Cox regression models, the combination of low pre-diagnostic physical exercise and either sarcopenia or myosteatosis at the time of diagnosis was associated with cancer-specific mortality compared to the reference group of high physical exercise combined with no sarcopenia/myosteatosis (adjusted HR 1.94 95% CI 1.00–3.76 for sarcopenia and adjusted HR 2.39 95% CI 1.16–4.94 for myosteatosis). CONCLUSIONS: The combined presence of low pre-diagnostic physical exercise and sarcopenia or myosteatosis was associated with increased CRC-specific mortality. Despite the positive effect on prognosis, physical exercise did not alter body composition estimates at diagnosis, which could indicate attenuation from other factors. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00384-023-04536-0. Text Northern Sweden PubMed Central (PMC) International Journal of Colorectal Disease 38 1 |
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Research |
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Research Renman, David van Guelpen, Bethany Anderson, Fredrick Axelsson, Jan Riklund, Katrine Strigård, Karin Palmqvist, Richard Gunnarsson, Ulf Gylling, Björn Association of pre-diagnostic physical exercise and peri-diagnostic body composition with mortality in non-metastatic colorectal cancer |
topic_facet |
Research |
description |
PURPOSE: Sarcopenia and myosteatosis, quantified via computed tomography (CT), are associated with poor colorectal cancer outcomes. These body composition estimates can be influenced by physical exercise. We explored the correlation between pre-diagnostic physical exercise, body composition close to diagnosis, and the combined prognosis impact of these factors. METHODS: We studied 519 stage I–III colorectal cancer (CRC) cases diagnosed 2000–2016 with pre-diagnostic self-reported recreational physical exercise data collected in the prospective, population-based Northern Sweden Health and Disease Study, and CT-estimated skeletal muscle index (SMI) or skeletal muscle density (SMD). Risk estimates were calculated by multivariable logistic regression and Cox proportional hazards models. RESULTS: No association was seen between low pre-diagnostic physical exercise and sarcopenia/myosteatosis in the multivariable model adjusted for age, sex, educational level, tumor stage, and tumor location. In multivariable Cox regression models, the combination of low pre-diagnostic physical exercise and either sarcopenia or myosteatosis at the time of diagnosis was associated with cancer-specific mortality compared to the reference group of high physical exercise combined with no sarcopenia/myosteatosis (adjusted HR 1.94 95% CI 1.00–3.76 for sarcopenia and adjusted HR 2.39 95% CI 1.16–4.94 for myosteatosis). CONCLUSIONS: The combined presence of low pre-diagnostic physical exercise and sarcopenia or myosteatosis was associated with increased CRC-specific mortality. Despite the positive effect on prognosis, physical exercise did not alter body composition estimates at diagnosis, which could indicate attenuation from other factors. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00384-023-04536-0. |
format |
Text |
author |
Renman, David van Guelpen, Bethany Anderson, Fredrick Axelsson, Jan Riklund, Katrine Strigård, Karin Palmqvist, Richard Gunnarsson, Ulf Gylling, Björn |
author_facet |
Renman, David van Guelpen, Bethany Anderson, Fredrick Axelsson, Jan Riklund, Katrine Strigård, Karin Palmqvist, Richard Gunnarsson, Ulf Gylling, Björn |
author_sort |
Renman, David |
title |
Association of pre-diagnostic physical exercise and peri-diagnostic body composition with mortality in non-metastatic colorectal cancer |
title_short |
Association of pre-diagnostic physical exercise and peri-diagnostic body composition with mortality in non-metastatic colorectal cancer |
title_full |
Association of pre-diagnostic physical exercise and peri-diagnostic body composition with mortality in non-metastatic colorectal cancer |
title_fullStr |
Association of pre-diagnostic physical exercise and peri-diagnostic body composition with mortality in non-metastatic colorectal cancer |
title_full_unstemmed |
Association of pre-diagnostic physical exercise and peri-diagnostic body composition with mortality in non-metastatic colorectal cancer |
title_sort |
association of pre-diagnostic physical exercise and peri-diagnostic body composition with mortality in non-metastatic colorectal cancer |
publisher |
Springer Berlin Heidelberg |
publishDate |
2023 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10533590/ http://www.ncbi.nlm.nih.gov/pubmed/37755537 https://doi.org/10.1007/s00384-023-04536-0 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_source |
Int J Colorectal Dis |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10533590/ http://www.ncbi.nlm.nih.gov/pubmed/37755537 http://dx.doi.org/10.1007/s00384-023-04536-0 |
op_rights |
© The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
op_doi |
https://doi.org/10.1007/s00384-023-04536-0 |
container_title |
International Journal of Colorectal Disease |
container_volume |
38 |
container_issue |
1 |
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1781065480274968576 |