Anti-Hyperlipidemic Effect of Fucoidan Fractions Prepared from Iceland Brown Algae Ascophyllum nodosum in an Hyperlipidemic Mice Model
Ascophyllum nodosum, a brown algae abundantly found along the North Atlantic coast, is recognized for its high polysaccharide content. In this study, we investigated the anti-hyperlipidemic effect of fucoidans derived from A. nodosum, aiming to provide information for their potential application in...
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Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10533094/ http://www.ncbi.nlm.nih.gov/pubmed/37755081 https://doi.org/10.3390/md21090468 |
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ftpubmed:oai:pubmedcentral.nih.gov:10533094 2023-10-29T02:37:20+01:00 Anti-Hyperlipidemic Effect of Fucoidan Fractions Prepared from Iceland Brown Algae Ascophyllum nodosum in an Hyperlipidemic Mice Model He, Yunhai Li, Yutong Shen, Peili Li, Shangkun Zhang, Linsong Wang, Qiukuan Ren, Dandan Liu, Shu Zhang, Demeng Zhou, Hui 2023-08-26 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10533094/ http://www.ncbi.nlm.nih.gov/pubmed/37755081 https://doi.org/10.3390/md21090468 en eng MDPI http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10533094/ http://www.ncbi.nlm.nih.gov/pubmed/37755081 http://dx.doi.org/10.3390/md21090468 © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Mar Drugs Article Text 2023 ftpubmed https://doi.org/10.3390/md21090468 2023-10-01T01:16:17Z Ascophyllum nodosum, a brown algae abundantly found along the North Atlantic coast, is recognized for its high polysaccharide content. In this study, we investigated the anti-hyperlipidemic effect of fucoidans derived from A. nodosum, aiming to provide information for their potential application in anti-hyperlipidemic therapies and to explore comprehensive utilization of this Iceland brown seaweed. The crude fucoidan prepared from A. nodosum was separated using a diethylethanolamine column, resulting in two fucoidan fractions, AFC-1 and AFC-2. Both fractions were predominantly composed of fucose and xylose. AFC-1 exhibited a higher sulfate content of 27.8% compared to AFC-2 with 17.0%. AFC-2 was primarily sulfated at the hydroxy group of C2, whereas AFC-1 was sulfated at both the hydroxy groups of C2 and C4. To evaluate the anti-hyperlipidemic effect, a hyperlipidemia mouse model was established by feeding mice a high-fat diet. The effects of AFC-1, AFC-2, and the crude extract were investigated, with the drug atorvastatin used as a positive comparison. Among the different fucoidan fractions and doses, the high dose of AFC-2 administration demonstrated the most significant anti-hyperlipidemic effect across various aspects, including physiological parameters, blood glucose levels, lipid profile, histological analysis, and the activities of oxidative stress-related enzymes and lipoprotein-metabolism-related enzymes (p < 0.05 for the final body weight and p < 0.01 for the rest indicators, compared with the model group), and its effect is comparable to the atorvastatin administration. Furthermore, fucoidan administration resulted in a lower degree of loss in gut flora diversity compared to atorvastatin administration. These findings highlight the significant biomedical potential of fucoidans derived from A. nodosum as a promising therapeutic solution for hypolipidemia. Text Iceland North Atlantic PubMed Central (PMC) Marine Drugs 21 9 468 |
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Article He, Yunhai Li, Yutong Shen, Peili Li, Shangkun Zhang, Linsong Wang, Qiukuan Ren, Dandan Liu, Shu Zhang, Demeng Zhou, Hui Anti-Hyperlipidemic Effect of Fucoidan Fractions Prepared from Iceland Brown Algae Ascophyllum nodosum in an Hyperlipidemic Mice Model |
topic_facet |
Article |
description |
Ascophyllum nodosum, a brown algae abundantly found along the North Atlantic coast, is recognized for its high polysaccharide content. In this study, we investigated the anti-hyperlipidemic effect of fucoidans derived from A. nodosum, aiming to provide information for their potential application in anti-hyperlipidemic therapies and to explore comprehensive utilization of this Iceland brown seaweed. The crude fucoidan prepared from A. nodosum was separated using a diethylethanolamine column, resulting in two fucoidan fractions, AFC-1 and AFC-2. Both fractions were predominantly composed of fucose and xylose. AFC-1 exhibited a higher sulfate content of 27.8% compared to AFC-2 with 17.0%. AFC-2 was primarily sulfated at the hydroxy group of C2, whereas AFC-1 was sulfated at both the hydroxy groups of C2 and C4. To evaluate the anti-hyperlipidemic effect, a hyperlipidemia mouse model was established by feeding mice a high-fat diet. The effects of AFC-1, AFC-2, and the crude extract were investigated, with the drug atorvastatin used as a positive comparison. Among the different fucoidan fractions and doses, the high dose of AFC-2 administration demonstrated the most significant anti-hyperlipidemic effect across various aspects, including physiological parameters, blood glucose levels, lipid profile, histological analysis, and the activities of oxidative stress-related enzymes and lipoprotein-metabolism-related enzymes (p < 0.05 for the final body weight and p < 0.01 for the rest indicators, compared with the model group), and its effect is comparable to the atorvastatin administration. Furthermore, fucoidan administration resulted in a lower degree of loss in gut flora diversity compared to atorvastatin administration. These findings highlight the significant biomedical potential of fucoidans derived from A. nodosum as a promising therapeutic solution for hypolipidemia. |
format |
Text |
author |
He, Yunhai Li, Yutong Shen, Peili Li, Shangkun Zhang, Linsong Wang, Qiukuan Ren, Dandan Liu, Shu Zhang, Demeng Zhou, Hui |
author_facet |
He, Yunhai Li, Yutong Shen, Peili Li, Shangkun Zhang, Linsong Wang, Qiukuan Ren, Dandan Liu, Shu Zhang, Demeng Zhou, Hui |
author_sort |
He, Yunhai |
title |
Anti-Hyperlipidemic Effect of Fucoidan Fractions Prepared from Iceland Brown Algae Ascophyllum nodosum in an Hyperlipidemic Mice Model |
title_short |
Anti-Hyperlipidemic Effect of Fucoidan Fractions Prepared from Iceland Brown Algae Ascophyllum nodosum in an Hyperlipidemic Mice Model |
title_full |
Anti-Hyperlipidemic Effect of Fucoidan Fractions Prepared from Iceland Brown Algae Ascophyllum nodosum in an Hyperlipidemic Mice Model |
title_fullStr |
Anti-Hyperlipidemic Effect of Fucoidan Fractions Prepared from Iceland Brown Algae Ascophyllum nodosum in an Hyperlipidemic Mice Model |
title_full_unstemmed |
Anti-Hyperlipidemic Effect of Fucoidan Fractions Prepared from Iceland Brown Algae Ascophyllum nodosum in an Hyperlipidemic Mice Model |
title_sort |
anti-hyperlipidemic effect of fucoidan fractions prepared from iceland brown algae ascophyllum nodosum in an hyperlipidemic mice model |
publisher |
MDPI |
publishDate |
2023 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10533094/ http://www.ncbi.nlm.nih.gov/pubmed/37755081 https://doi.org/10.3390/md21090468 |
genre |
Iceland North Atlantic |
genre_facet |
Iceland North Atlantic |
op_source |
Mar Drugs |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10533094/ http://www.ncbi.nlm.nih.gov/pubmed/37755081 http://dx.doi.org/10.3390/md21090468 |
op_rights |
© 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
op_doi |
https://doi.org/10.3390/md21090468 |
container_title |
Marine Drugs |
container_volume |
21 |
container_issue |
9 |
container_start_page |
468 |
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1781061966354186240 |