Determination of chemical constituent yields in e-cigarette aerosol using partial and whole pod collections, a comparative analysis
Literature reports the chemical constituent yields of electronic nicotine delivery systems (ENDS) aerosol collected using a range of aerosol collection strategies. The number of puffs to deplete an ENDS product varies widely, but collections often consist of data from the first 50–100 puffs. However...
Published in: | Frontiers in Chemistry |
---|---|
Main Authors: | , , , , , , , , , , |
Format: | Text |
Language: | English |
Published: |
Frontiers Media S.A.
2023
|
Subjects: | |
Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10512464/ https://doi.org/10.3389/fchem.2023.1223967 |
id |
ftpubmed:oai:pubmedcentral.nih.gov:10512464 |
---|---|
record_format |
openpolar |
spelling |
ftpubmed:oai:pubmedcentral.nih.gov:10512464 2023-10-09T21:51:03+02:00 Determination of chemical constituent yields in e-cigarette aerosol using partial and whole pod collections, a comparative analysis Jameson, J. Brian Wang, Jiaming Bailey, Patrick C. Oldham, Michael J. Smith, Cameron R. Jeong, Lena N. Cook, David K. Bates, Austin L. Ullah, Sifat Pennington, Alexander S. C. Gillman, I. Gene 2023-09-07 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10512464/ https://doi.org/10.3389/fchem.2023.1223967 en eng Frontiers Media S.A. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10512464/ http://dx.doi.org/10.3389/fchem.2023.1223967 Copyright © 2023 Jameson, Wang, Bailey, Oldham, Smith, Jeong, Cook, Bates, Ullah, Pennington and Gillman. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Front Chem Chemistry Text 2023 ftpubmed https://doi.org/10.3389/fchem.2023.1223967 2023-09-24T01:01:32Z Literature reports the chemical constituent yields of electronic nicotine delivery systems (ENDS) aerosol collected using a range of aerosol collection strategies. The number of puffs to deplete an ENDS product varies widely, but collections often consist of data from the first 50–100 puffs. However, it is not clear whether these discrete puff blocks are representative of constituent yields over the life of a pod. We aimed to assess the effect of differing aerosol collection strategies on reported yields for select chemical constituents in the aerosol of closed pod-based ENDS products. Constituents analyzed were chosen to reflect important classes of compounds from the Final Premarket Tobacco Product Application Guidance. Yields were normalized to total device mass loss (DML). Collection strategies that consisted of partial pod collection were valid for determining yields of constituents whose DML normalized yields were consistent for the duration of pod life. These included primary aerosol constituents, such as propylene glycol, glycerol, and nicotine, and whole pod yields could be determined from initial puff blocks. However, changes were observed in the yields of some metals, some carbonyl compounds, and glycidol over pod life in a chemical constituent and product dependent manner. These results suggest that collection strategies consisting of initial puff block collections require validation per chemical constituent/product and are not appropriate for chemical constituents with variable yields over pod life. Whole pod collection increased sensitivity and accuracy in determining metal, carbonyl, and glycidol yields compared to puff block-based collection methodologies for all products tested. Text DML PubMed Central (PMC) Frontiers in Chemistry 11 |
institution |
Open Polar |
collection |
PubMed Central (PMC) |
op_collection_id |
ftpubmed |
language |
English |
topic |
Chemistry |
spellingShingle |
Chemistry Jameson, J. Brian Wang, Jiaming Bailey, Patrick C. Oldham, Michael J. Smith, Cameron R. Jeong, Lena N. Cook, David K. Bates, Austin L. Ullah, Sifat Pennington, Alexander S. C. Gillman, I. Gene Determination of chemical constituent yields in e-cigarette aerosol using partial and whole pod collections, a comparative analysis |
topic_facet |
Chemistry |
description |
Literature reports the chemical constituent yields of electronic nicotine delivery systems (ENDS) aerosol collected using a range of aerosol collection strategies. The number of puffs to deplete an ENDS product varies widely, but collections often consist of data from the first 50–100 puffs. However, it is not clear whether these discrete puff blocks are representative of constituent yields over the life of a pod. We aimed to assess the effect of differing aerosol collection strategies on reported yields for select chemical constituents in the aerosol of closed pod-based ENDS products. Constituents analyzed were chosen to reflect important classes of compounds from the Final Premarket Tobacco Product Application Guidance. Yields were normalized to total device mass loss (DML). Collection strategies that consisted of partial pod collection were valid for determining yields of constituents whose DML normalized yields were consistent for the duration of pod life. These included primary aerosol constituents, such as propylene glycol, glycerol, and nicotine, and whole pod yields could be determined from initial puff blocks. However, changes were observed in the yields of some metals, some carbonyl compounds, and glycidol over pod life in a chemical constituent and product dependent manner. These results suggest that collection strategies consisting of initial puff block collections require validation per chemical constituent/product and are not appropriate for chemical constituents with variable yields over pod life. Whole pod collection increased sensitivity and accuracy in determining metal, carbonyl, and glycidol yields compared to puff block-based collection methodologies for all products tested. |
format |
Text |
author |
Jameson, J. Brian Wang, Jiaming Bailey, Patrick C. Oldham, Michael J. Smith, Cameron R. Jeong, Lena N. Cook, David K. Bates, Austin L. Ullah, Sifat Pennington, Alexander S. C. Gillman, I. Gene |
author_facet |
Jameson, J. Brian Wang, Jiaming Bailey, Patrick C. Oldham, Michael J. Smith, Cameron R. Jeong, Lena N. Cook, David K. Bates, Austin L. Ullah, Sifat Pennington, Alexander S. C. Gillman, I. Gene |
author_sort |
Jameson, J. Brian |
title |
Determination of chemical constituent yields in e-cigarette aerosol using partial and whole pod collections, a comparative analysis |
title_short |
Determination of chemical constituent yields in e-cigarette aerosol using partial and whole pod collections, a comparative analysis |
title_full |
Determination of chemical constituent yields in e-cigarette aerosol using partial and whole pod collections, a comparative analysis |
title_fullStr |
Determination of chemical constituent yields in e-cigarette aerosol using partial and whole pod collections, a comparative analysis |
title_full_unstemmed |
Determination of chemical constituent yields in e-cigarette aerosol using partial and whole pod collections, a comparative analysis |
title_sort |
determination of chemical constituent yields in e-cigarette aerosol using partial and whole pod collections, a comparative analysis |
publisher |
Frontiers Media S.A. |
publishDate |
2023 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10512464/ https://doi.org/10.3389/fchem.2023.1223967 |
genre |
DML |
genre_facet |
DML |
op_source |
Front Chem |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10512464/ http://dx.doi.org/10.3389/fchem.2023.1223967 |
op_rights |
Copyright © 2023 Jameson, Wang, Bailey, Oldham, Smith, Jeong, Cook, Bates, Ullah, Pennington and Gillman. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
op_doi |
https://doi.org/10.3389/fchem.2023.1223967 |
container_title |
Frontiers in Chemistry |
container_volume |
11 |
_version_ |
1779314144754794496 |