Case report: Canine distemper virus infection as a cause of central nervous system disease in a Eurasian lynx (Lynx lynx)
The Eurasian lynx (Lynx lynx) represents an endangered species with only small populations remaining in Central Europe. Knowledge about the threat posed by potential infectious agents to these animals is crucial for informing ongoing protection measures. Canine distemper virus (CDV) is known to have...
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ftpubmed:oai:pubmedcentral.nih.gov:10461803 2023-10-01T04:00:09+02:00 Case report: Canine distemper virus infection as a cause of central nervous system disease in a Eurasian lynx (Lynx lynx) Lombardo, Mara Sophie Mirolo, Monica Brandes, Florian Osterhaus, Albert D. M. E. Schütte, Karolin Ludlow, Martin Barkhoff, Michael Baumgärtner, Wolfgang Puff, Christina 2023-08-14 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10461803/ http://www.ncbi.nlm.nih.gov/pubmed/37645675 https://doi.org/10.3389/fvets.2023.1251018 en eng Frontiers Media S.A. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10461803/ http://www.ncbi.nlm.nih.gov/pubmed/37645675 http://dx.doi.org/10.3389/fvets.2023.1251018 Copyright © 2023 Lombardo, Mirolo, Brandes, Osterhaus, Schütte, Ludlow, Barkhoff, Baumgärtner and Puff. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Front Vet Sci Veterinary Science Text 2023 ftpubmed https://doi.org/10.3389/fvets.2023.1251018 2023-09-03T01:13:50Z The Eurasian lynx (Lynx lynx) represents an endangered species with only small populations remaining in Central Europe. Knowledge about the threat posed by potential infectious agents to these animals is crucial for informing ongoing protection measures. Canine distemper virus (CDV) is known to have a wide host range with infection reported in many mammalian species including several lynx species (Lynx pardinus, Lynx canadensis, Lynx rufus), but is an extremely rare finding in the Eurasian lynx. The present report describes a case of a Eurasian lynx showing central nervous signs, including apathy and ataxia. A CT scan revealed multiple hypodense areas in different localizations within the brain as well as enlarged liquid filled areas, leading to the suspicion of a degenerative process. Due to clinical deterioration, the animal was euthanized and submitted for macroscopical and histological investigations. Histological investigations revealed multifocal demyelinations in the cerebellum, brain stem and cervical spinal cord as well as a multifocal, perivascular, lymphohistiocytic meningoencephalitis. A CDV infection was confirmed by immunohistochemistry and RT-PCR analyses. This CDV infection of a Eurasian lynx resembles a classical chronic manifestation of distemper in dogs and highlights the threat posed by canine distemper to this species. Text Lynx Lynx lynx lynx PubMed Central (PMC) Frontiers in Veterinary Science 10 |
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Veterinary Science Lombardo, Mara Sophie Mirolo, Monica Brandes, Florian Osterhaus, Albert D. M. E. Schütte, Karolin Ludlow, Martin Barkhoff, Michael Baumgärtner, Wolfgang Puff, Christina Case report: Canine distemper virus infection as a cause of central nervous system disease in a Eurasian lynx (Lynx lynx) |
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Veterinary Science |
description |
The Eurasian lynx (Lynx lynx) represents an endangered species with only small populations remaining in Central Europe. Knowledge about the threat posed by potential infectious agents to these animals is crucial for informing ongoing protection measures. Canine distemper virus (CDV) is known to have a wide host range with infection reported in many mammalian species including several lynx species (Lynx pardinus, Lynx canadensis, Lynx rufus), but is an extremely rare finding in the Eurasian lynx. The present report describes a case of a Eurasian lynx showing central nervous signs, including apathy and ataxia. A CT scan revealed multiple hypodense areas in different localizations within the brain as well as enlarged liquid filled areas, leading to the suspicion of a degenerative process. Due to clinical deterioration, the animal was euthanized and submitted for macroscopical and histological investigations. Histological investigations revealed multifocal demyelinations in the cerebellum, brain stem and cervical spinal cord as well as a multifocal, perivascular, lymphohistiocytic meningoencephalitis. A CDV infection was confirmed by immunohistochemistry and RT-PCR analyses. This CDV infection of a Eurasian lynx resembles a classical chronic manifestation of distemper in dogs and highlights the threat posed by canine distemper to this species. |
format |
Text |
author |
Lombardo, Mara Sophie Mirolo, Monica Brandes, Florian Osterhaus, Albert D. M. E. Schütte, Karolin Ludlow, Martin Barkhoff, Michael Baumgärtner, Wolfgang Puff, Christina |
author_facet |
Lombardo, Mara Sophie Mirolo, Monica Brandes, Florian Osterhaus, Albert D. M. E. Schütte, Karolin Ludlow, Martin Barkhoff, Michael Baumgärtner, Wolfgang Puff, Christina |
author_sort |
Lombardo, Mara Sophie |
title |
Case report: Canine distemper virus infection as a cause of central nervous system disease in a Eurasian lynx (Lynx lynx) |
title_short |
Case report: Canine distemper virus infection as a cause of central nervous system disease in a Eurasian lynx (Lynx lynx) |
title_full |
Case report: Canine distemper virus infection as a cause of central nervous system disease in a Eurasian lynx (Lynx lynx) |
title_fullStr |
Case report: Canine distemper virus infection as a cause of central nervous system disease in a Eurasian lynx (Lynx lynx) |
title_full_unstemmed |
Case report: Canine distemper virus infection as a cause of central nervous system disease in a Eurasian lynx (Lynx lynx) |
title_sort |
case report: canine distemper virus infection as a cause of central nervous system disease in a eurasian lynx (lynx lynx) |
publisher |
Frontiers Media S.A. |
publishDate |
2023 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10461803/ http://www.ncbi.nlm.nih.gov/pubmed/37645675 https://doi.org/10.3389/fvets.2023.1251018 |
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Lynx Lynx lynx lynx |
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Lynx Lynx lynx lynx |
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Front Vet Sci |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10461803/ http://www.ncbi.nlm.nih.gov/pubmed/37645675 http://dx.doi.org/10.3389/fvets.2023.1251018 |
op_rights |
Copyright © 2023 Lombardo, Mirolo, Brandes, Osterhaus, Schütte, Ludlow, Barkhoff, Baumgärtner and Puff. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
op_doi |
https://doi.org/10.3389/fvets.2023.1251018 |
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Frontiers in Veterinary Science |
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10 |
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