Identification of two novel papillomaviruses in belugas
INTRODUCTION: Papillomaviruses (PVs) can cause hyperplasia in the skin and mucous membranes of humans, mammals, and non-mammalian animals, and are a significant risk factor for cervical and genital cancers. METHODS: Using next-generation sequencing (NGS), we identified two novel strains of papilloma...
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ftpubmed:oai:pubmedcentral.nih.gov:10411887 2023-09-05T13:18:28+02:00 Identification of two novel papillomaviruses in belugas Li, Youyou Xiao, Meifang Zhang, Yun Li, Zihan Bai, Shijie Su, Haoxiang Peng, Ruoyan Wang, Gaoyu Hu, Xiaoyuan Song, Xinran Li, Xin Tang, Chuanning Lu, Gang Yin, Feifei Zhang, Peijun Du, Jiang 2023-07-26 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10411887/ https://doi.org/10.3389/fmicb.2023.1165839 en eng Frontiers Media S.A. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10411887/ http://dx.doi.org/10.3389/fmicb.2023.1165839 Copyright © 2023 Li, Xiao, Zhang, Li, Bai, Su, Peng, Wang, Hu, Song, Li, Tang, Lu, Yin, Zhang and Du. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Front Microbiol Microbiology Text 2023 ftpubmed https://doi.org/10.3389/fmicb.2023.1165839 2023-08-13T01:10:59Z INTRODUCTION: Papillomaviruses (PVs) can cause hyperplasia in the skin and mucous membranes of humans, mammals, and non-mammalian animals, and are a significant risk factor for cervical and genital cancers. METHODS: Using next-generation sequencing (NGS), we identified two novel strains of papillomavirus, PV-HMU-1 and PV-HMU-2, in swabs taken from belugas (Delphinapterus leucas) at Polar Ocean Parks in Qingdao and Dalian. RESULTS: We amplified the complete genomes of both strains and screened ten belugas and one false killer whale (Pseudorca crassidens) for the late gene (L1) to determine the infection rate. In Qingdao, 50% of the two sampled belugas were infected with PV-HMU-1, while the false killer whale was negative. In Dalian, 71% of the eight sampled belugas were infected with PV-HMU-2. In their L1 genes, PV-HMU-1 and PV-HMU-2 showed 64.99 and 68.12% amino acid identity, respectively, with other members of Papillomaviridae. Phylogenetic analysis of combinatorial amino acid sequences revealed that PV-HMU-1 and PV-HMU-2 clustered with other known dolphin PVs but formed distinct branches. PVs carried by belugas were proposed as novel species under Firstpapillomavirinae. CONCLUSION: The discovery of these two novel PVs enhances our understanding of the genetic diversity of papillomaviruses and their impact on the beluga population. Text Beluga Beluga* Delphinapterus leucas Killer Whale PubMed Central (PMC) Frontiers in Microbiology 14 |
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Microbiology |
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Microbiology Li, Youyou Xiao, Meifang Zhang, Yun Li, Zihan Bai, Shijie Su, Haoxiang Peng, Ruoyan Wang, Gaoyu Hu, Xiaoyuan Song, Xinran Li, Xin Tang, Chuanning Lu, Gang Yin, Feifei Zhang, Peijun Du, Jiang Identification of two novel papillomaviruses in belugas |
topic_facet |
Microbiology |
description |
INTRODUCTION: Papillomaviruses (PVs) can cause hyperplasia in the skin and mucous membranes of humans, mammals, and non-mammalian animals, and are a significant risk factor for cervical and genital cancers. METHODS: Using next-generation sequencing (NGS), we identified two novel strains of papillomavirus, PV-HMU-1 and PV-HMU-2, in swabs taken from belugas (Delphinapterus leucas) at Polar Ocean Parks in Qingdao and Dalian. RESULTS: We amplified the complete genomes of both strains and screened ten belugas and one false killer whale (Pseudorca crassidens) for the late gene (L1) to determine the infection rate. In Qingdao, 50% of the two sampled belugas were infected with PV-HMU-1, while the false killer whale was negative. In Dalian, 71% of the eight sampled belugas were infected with PV-HMU-2. In their L1 genes, PV-HMU-1 and PV-HMU-2 showed 64.99 and 68.12% amino acid identity, respectively, with other members of Papillomaviridae. Phylogenetic analysis of combinatorial amino acid sequences revealed that PV-HMU-1 and PV-HMU-2 clustered with other known dolphin PVs but formed distinct branches. PVs carried by belugas were proposed as novel species under Firstpapillomavirinae. CONCLUSION: The discovery of these two novel PVs enhances our understanding of the genetic diversity of papillomaviruses and their impact on the beluga population. |
format |
Text |
author |
Li, Youyou Xiao, Meifang Zhang, Yun Li, Zihan Bai, Shijie Su, Haoxiang Peng, Ruoyan Wang, Gaoyu Hu, Xiaoyuan Song, Xinran Li, Xin Tang, Chuanning Lu, Gang Yin, Feifei Zhang, Peijun Du, Jiang |
author_facet |
Li, Youyou Xiao, Meifang Zhang, Yun Li, Zihan Bai, Shijie Su, Haoxiang Peng, Ruoyan Wang, Gaoyu Hu, Xiaoyuan Song, Xinran Li, Xin Tang, Chuanning Lu, Gang Yin, Feifei Zhang, Peijun Du, Jiang |
author_sort |
Li, Youyou |
title |
Identification of two novel papillomaviruses in belugas |
title_short |
Identification of two novel papillomaviruses in belugas |
title_full |
Identification of two novel papillomaviruses in belugas |
title_fullStr |
Identification of two novel papillomaviruses in belugas |
title_full_unstemmed |
Identification of two novel papillomaviruses in belugas |
title_sort |
identification of two novel papillomaviruses in belugas |
publisher |
Frontiers Media S.A. |
publishDate |
2023 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10411887/ https://doi.org/10.3389/fmicb.2023.1165839 |
genre |
Beluga Beluga* Delphinapterus leucas Killer Whale |
genre_facet |
Beluga Beluga* Delphinapterus leucas Killer Whale |
op_source |
Front Microbiol |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10411887/ http://dx.doi.org/10.3389/fmicb.2023.1165839 |
op_rights |
Copyright © 2023 Li, Xiao, Zhang, Li, Bai, Su, Peng, Wang, Hu, Song, Li, Tang, Lu, Yin, Zhang and Du. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
op_doi |
https://doi.org/10.3389/fmicb.2023.1165839 |
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Frontiers in Microbiology |
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14 |
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1776199417511018496 |