Application of topical rocuronium bromide dosing by ocular size in four species of wild birds
BACKGROUND: Rocuronium bromide has been evaluated as a mydriatic agent in birds, but the species applied were limited and the dose and effect were variable. OBJECTIVE: This study aims to evaluate the efficacy of topical rocuronium bromide as mydriatics in 4 species according to horizontal palpebral...
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ftpubmed:oai:pubmedcentral.nih.gov:10404711 2023-09-05T13:19:16+02:00 Application of topical rocuronium bromide dosing by ocular size in four species of wild birds Rhim, Haerin Jung, Sunjun Kim, Namsoo Han, Jae-Ik 2023-07-14 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404711/ http://www.ncbi.nlm.nih.gov/pubmed/37532302 https://doi.org/10.4142/jvs.23002 en eng The Korean Society of Veterinary Science http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404711/ http://www.ncbi.nlm.nih.gov/pubmed/37532302 http://dx.doi.org/10.4142/jvs.23002 © 2023 The Korean Society of Veterinary Science https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. J Vet Sci Original Article Text 2023 ftpubmed https://doi.org/10.4142/jvs.23002 2023-08-13T00:50:07Z BACKGROUND: Rocuronium bromide has been evaluated as a mydriatic agent in birds, but the species applied were limited and the dose and effect were variable. OBJECTIVE: This study aims to evaluate the efficacy of topical rocuronium bromide as mydriatics in 4 species according to horizontal palpebral fissure length: Feral pigeon (Columba livia), Common kestrel (Falco tinnunculus), Northern boobook (Ninox japonica), and Eurasian eagle owl (Bubo bubo). METHODS: A total of 32 birds (8 for each species) were included as pre-releasing examination. Rocuronium bromide was instilled in one randomly selected eye of each bird based on palpebral fissure length criteria (0.5 mg/50 µL for pigeons, 1 mg/100 µL for kestrels and boobook owls, and 2 mg/200 µL for eagle owls). The contralateral eye was used as control and treated with normal saline. After instillation of the drug, pupil diameter, pupillary light reflex, intraocular pressure, heart rate, and respiratory rate were evaluated at 10 min intervals up to 180 min and at 30 min intervals up to 360 min. RESULTS: Statistically significant mydriasis was obtained in all birds (p < 0.001). However, in boobook and eagle owls, marked mydriasis persisted until 360 min. Side effects including corneal erosion and lower eyelid paralysis were common, which was observed in 26/32 birds. Blepharospasm was also noted during this study. No systemic adverse signs were observed. CONCLUSIONS: Rocuronium bromide could be a good mydriatics option for 4 species of birds, however, further studies are needed to find lowest effective dose to reduce drug-related side effects. Text eurasian eagle-owl PubMed Central (PMC) Journal of Veterinary Science 24 4 |
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Original Article Rhim, Haerin Jung, Sunjun Kim, Namsoo Han, Jae-Ik Application of topical rocuronium bromide dosing by ocular size in four species of wild birds |
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Original Article |
description |
BACKGROUND: Rocuronium bromide has been evaluated as a mydriatic agent in birds, but the species applied were limited and the dose and effect were variable. OBJECTIVE: This study aims to evaluate the efficacy of topical rocuronium bromide as mydriatics in 4 species according to horizontal palpebral fissure length: Feral pigeon (Columba livia), Common kestrel (Falco tinnunculus), Northern boobook (Ninox japonica), and Eurasian eagle owl (Bubo bubo). METHODS: A total of 32 birds (8 for each species) were included as pre-releasing examination. Rocuronium bromide was instilled in one randomly selected eye of each bird based on palpebral fissure length criteria (0.5 mg/50 µL for pigeons, 1 mg/100 µL for kestrels and boobook owls, and 2 mg/200 µL for eagle owls). The contralateral eye was used as control and treated with normal saline. After instillation of the drug, pupil diameter, pupillary light reflex, intraocular pressure, heart rate, and respiratory rate were evaluated at 10 min intervals up to 180 min and at 30 min intervals up to 360 min. RESULTS: Statistically significant mydriasis was obtained in all birds (p < 0.001). However, in boobook and eagle owls, marked mydriasis persisted until 360 min. Side effects including corneal erosion and lower eyelid paralysis were common, which was observed in 26/32 birds. Blepharospasm was also noted during this study. No systemic adverse signs were observed. CONCLUSIONS: Rocuronium bromide could be a good mydriatics option for 4 species of birds, however, further studies are needed to find lowest effective dose to reduce drug-related side effects. |
format |
Text |
author |
Rhim, Haerin Jung, Sunjun Kim, Namsoo Han, Jae-Ik |
author_facet |
Rhim, Haerin Jung, Sunjun Kim, Namsoo Han, Jae-Ik |
author_sort |
Rhim, Haerin |
title |
Application of topical rocuronium bromide dosing by ocular size in four species of wild birds |
title_short |
Application of topical rocuronium bromide dosing by ocular size in four species of wild birds |
title_full |
Application of topical rocuronium bromide dosing by ocular size in four species of wild birds |
title_fullStr |
Application of topical rocuronium bromide dosing by ocular size in four species of wild birds |
title_full_unstemmed |
Application of topical rocuronium bromide dosing by ocular size in four species of wild birds |
title_sort |
application of topical rocuronium bromide dosing by ocular size in four species of wild birds |
publisher |
The Korean Society of Veterinary Science |
publishDate |
2023 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404711/ http://www.ncbi.nlm.nih.gov/pubmed/37532302 https://doi.org/10.4142/jvs.23002 |
genre |
eurasian eagle-owl |
genre_facet |
eurasian eagle-owl |
op_source |
J Vet Sci |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404711/ http://www.ncbi.nlm.nih.gov/pubmed/37532302 http://dx.doi.org/10.4142/jvs.23002 |
op_rights |
© 2023 The Korean Society of Veterinary Science https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
op_doi |
https://doi.org/10.4142/jvs.23002 |
container_title |
Journal of Veterinary Science |
container_volume |
24 |
container_issue |
4 |
_version_ |
1776200083653525504 |