Total n-3 fatty acid and SFA intakes in relation to insulin resistance in a Canadian First Nation at risk for the development of type 2 diabetes
OBJECTIVE: The present study sought to investigate the associations of total n-3 fatty acid and SFA intakes with insulin resistance in a Canadian First Nation sample at risk for type 2 diabetes. DESIGN: Fasting values for glucose and insulin were used to estimate insulin resistance by homeostasis mo...
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Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10282250/ http://www.ncbi.nlm.nih.gov/pubmed/23517921 https://doi.org/10.1017/S1368980013000542 |
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ftpubmed:oai:pubmedcentral.nih.gov:10282250 2023-10-01T03:56:01+02:00 Total n-3 fatty acid and SFA intakes in relation to insulin resistance in a Canadian First Nation at risk for the development of type 2 diabetes Paquet, Catherine Propsting, Sarah L Daniel, Mark 2013-03-21 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10282250/ http://www.ncbi.nlm.nih.gov/pubmed/23517921 https://doi.org/10.1017/S1368980013000542 en eng Cambridge University Press http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10282250/ http://www.ncbi.nlm.nih.gov/pubmed/23517921 http://dx.doi.org/10.1017/S1368980013000542 © The Authors 2013 Public Health Nutr Nutrition and Health Text 2013 ftpubmed https://doi.org/10.1017/S1368980013000542 2023-09-03T00:53:21Z OBJECTIVE: The present study sought to investigate the associations of total n-3 fatty acid and SFA intakes with insulin resistance in a Canadian First Nation sample at risk for type 2 diabetes. DESIGN: Fasting values for glucose and insulin were used to estimate insulin resistance by homeostasis model assessment (HOMA-IR). Intakes of n-3 fatty acids and SFA were computed from dietary food and drink data obtained using 3 d food records. Associations between HOMA-IR and dietary n-3 and SFA consumption were tested using linear regression models accounting for age, sex, community, education, physical activity, waist circumference, fibre, protein and carbohydrate intakes, and HDL-cholesterol and TAG concentrations. SETTING: Rural Okanagan region of British Columbia, Canada. SUBJECTS: On-reserve First Nation individuals (Interior Salishan) aged 18 years and over, recruited for community-based diabetes screening and determined to be normoglycaemic (n 126). RESULTS: HOMA-IR was negatively associated with dietary n-3 fatty acid intake (β = −0·22; 95 % CI −0·39, −0·04; P = 0·016) and positively associated with dietary SFA intake (β = 0·34; 95 % CI 0·15, 0·53; P = 0·0 0 1). CONCLUSIONS: Intake of dietary n-3 fatty acids may be protective against whereas SFA intake may promote insulin resistance in this high-risk Canadian First Nation sample. Reduced dietary SFA intake and greater n-3 fatty acid intake may assist the prevention of glycaemic disease among First Nations peoples. More rigorous, controlled trials are required to test whether dietary supplementation with n-3 fatty acids in natural or supplement-based form might reduce diabetes risk in high-risk aboriginal groups. Text First Nations PubMed Central (PMC) Canada British Columbia ENVELOPE(-125.003,-125.003,54.000,54.000) Public Health Nutrition 17 6 1337 1341 |
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English |
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Nutrition and Health |
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Nutrition and Health Paquet, Catherine Propsting, Sarah L Daniel, Mark Total n-3 fatty acid and SFA intakes in relation to insulin resistance in a Canadian First Nation at risk for the development of type 2 diabetes |
topic_facet |
Nutrition and Health |
description |
OBJECTIVE: The present study sought to investigate the associations of total n-3 fatty acid and SFA intakes with insulin resistance in a Canadian First Nation sample at risk for type 2 diabetes. DESIGN: Fasting values for glucose and insulin were used to estimate insulin resistance by homeostasis model assessment (HOMA-IR). Intakes of n-3 fatty acids and SFA were computed from dietary food and drink data obtained using 3 d food records. Associations between HOMA-IR and dietary n-3 and SFA consumption were tested using linear regression models accounting for age, sex, community, education, physical activity, waist circumference, fibre, protein and carbohydrate intakes, and HDL-cholesterol and TAG concentrations. SETTING: Rural Okanagan region of British Columbia, Canada. SUBJECTS: On-reserve First Nation individuals (Interior Salishan) aged 18 years and over, recruited for community-based diabetes screening and determined to be normoglycaemic (n 126). RESULTS: HOMA-IR was negatively associated with dietary n-3 fatty acid intake (β = −0·22; 95 % CI −0·39, −0·04; P = 0·016) and positively associated with dietary SFA intake (β = 0·34; 95 % CI 0·15, 0·53; P = 0·0 0 1). CONCLUSIONS: Intake of dietary n-3 fatty acids may be protective against whereas SFA intake may promote insulin resistance in this high-risk Canadian First Nation sample. Reduced dietary SFA intake and greater n-3 fatty acid intake may assist the prevention of glycaemic disease among First Nations peoples. More rigorous, controlled trials are required to test whether dietary supplementation with n-3 fatty acids in natural or supplement-based form might reduce diabetes risk in high-risk aboriginal groups. |
format |
Text |
author |
Paquet, Catherine Propsting, Sarah L Daniel, Mark |
author_facet |
Paquet, Catherine Propsting, Sarah L Daniel, Mark |
author_sort |
Paquet, Catherine |
title |
Total n-3 fatty acid and SFA intakes in relation to insulin resistance in a Canadian First Nation at risk for the development of type 2 diabetes |
title_short |
Total n-3 fatty acid and SFA intakes in relation to insulin resistance in a Canadian First Nation at risk for the development of type 2 diabetes |
title_full |
Total n-3 fatty acid and SFA intakes in relation to insulin resistance in a Canadian First Nation at risk for the development of type 2 diabetes |
title_fullStr |
Total n-3 fatty acid and SFA intakes in relation to insulin resistance in a Canadian First Nation at risk for the development of type 2 diabetes |
title_full_unstemmed |
Total n-3 fatty acid and SFA intakes in relation to insulin resistance in a Canadian First Nation at risk for the development of type 2 diabetes |
title_sort |
total n-3 fatty acid and sfa intakes in relation to insulin resistance in a canadian first nation at risk for the development of type 2 diabetes |
publisher |
Cambridge University Press |
publishDate |
2013 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10282250/ http://www.ncbi.nlm.nih.gov/pubmed/23517921 https://doi.org/10.1017/S1368980013000542 |
long_lat |
ENVELOPE(-125.003,-125.003,54.000,54.000) |
geographic |
Canada British Columbia |
geographic_facet |
Canada British Columbia |
genre |
First Nations |
genre_facet |
First Nations |
op_source |
Public Health Nutr |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10282250/ http://www.ncbi.nlm.nih.gov/pubmed/23517921 http://dx.doi.org/10.1017/S1368980013000542 |
op_rights |
© The Authors 2013 |
op_doi |
https://doi.org/10.1017/S1368980013000542 |
container_title |
Public Health Nutrition |
container_volume |
17 |
container_issue |
6 |
container_start_page |
1337 |
op_container_end_page |
1341 |
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1778525054580031488 |