Body mass index in the middle-aged offspring of parents with severe mental illness
BACKGROUND: People with severe mental illness (SMI) have an elevated risk of obesity but the causes and mechanisms are unclear. We explored the familial association between parental SMI and body mass index (BMI) in middle-aged offspring. Our objective was to determine if the offspring of either pare...
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ftpubmed:oai:pubmedcentral.nih.gov:10277759 2023-07-16T04:00:07+02:00 Body mass index in the middle-aged offspring of parents with severe mental illness Protsenko, Maria Kerkelä, Martta Miettunen, Jouko Auvinen, Juha Järvelin, Marjo-Riitta Jones, Peter B. Gissler, Mika Veijola, Juha 2023-06 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10277759/ http://www.ncbi.nlm.nih.gov/pubmed/35232502 https://doi.org/10.1017/S0033291722000253 en eng Cambridge University Press http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10277759/ http://www.ncbi.nlm.nih.gov/pubmed/35232502 http://dx.doi.org/10.1017/S0033291722000253 © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited. Psychol Med Original Article Text 2023 ftpubmed https://doi.org/10.1017/S0033291722000253 2023-06-25T00:49:45Z BACKGROUND: People with severe mental illness (SMI) have an elevated risk of obesity but the causes and mechanisms are unclear. We explored the familial association between parental SMI and body mass index (BMI) in middle-aged offspring. Our objective was to determine if the offspring of either parent with SMI have an increased risk for obesity. METHODS: The Northern Finland Birth Cohort 1966 is a cohort study of offspring with expected date of birth in 1966. The data include originally 12 068 mothers and 12 231 children from the provinces of Lapland and Oulu in Finland. The final study sample included 5050 middle-aged offspring. Parental SMI was used as exposure in the study. BMI measured at the age of 46 years was used as a primary outcome. RESULTS: Risk for obesity was elevated in the offspring of mothers with SMI [overweight: adjusted odds ratio (OR) 1.93 (1.29–2.90), obese class I: 1.97 (1.20–3.25), obese classes II–III: 2.98 (1.67–5.33)]. For the offspring of either parent with SMI, statistically significant results were found in obese class I and obese classes II–III [overweight: adjusted OR 1.21 (0.94–1.54), obese class I: 1.52 (1.03–1.08), obese classes II–III: 1.53 (1.01–2.32)]. CONCLUSIONS: We found an elevated risk of obesity in the middle-aged offspring of either parent with SMI, especially in the offspring of mothers with SMI. Thus, there might be a common familial pathway leading to the co-occurrence of obesity and SMI. Text Northern Finland Lapland PubMed Central (PMC) Psychological Medicine 53 8 3621 3627 |
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Original Article Protsenko, Maria Kerkelä, Martta Miettunen, Jouko Auvinen, Juha Järvelin, Marjo-Riitta Jones, Peter B. Gissler, Mika Veijola, Juha Body mass index in the middle-aged offspring of parents with severe mental illness |
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Original Article |
description |
BACKGROUND: People with severe mental illness (SMI) have an elevated risk of obesity but the causes and mechanisms are unclear. We explored the familial association between parental SMI and body mass index (BMI) in middle-aged offspring. Our objective was to determine if the offspring of either parent with SMI have an increased risk for obesity. METHODS: The Northern Finland Birth Cohort 1966 is a cohort study of offspring with expected date of birth in 1966. The data include originally 12 068 mothers and 12 231 children from the provinces of Lapland and Oulu in Finland. The final study sample included 5050 middle-aged offspring. Parental SMI was used as exposure in the study. BMI measured at the age of 46 years was used as a primary outcome. RESULTS: Risk for obesity was elevated in the offspring of mothers with SMI [overweight: adjusted odds ratio (OR) 1.93 (1.29–2.90), obese class I: 1.97 (1.20–3.25), obese classes II–III: 2.98 (1.67–5.33)]. For the offspring of either parent with SMI, statistically significant results were found in obese class I and obese classes II–III [overweight: adjusted OR 1.21 (0.94–1.54), obese class I: 1.52 (1.03–1.08), obese classes II–III: 1.53 (1.01–2.32)]. CONCLUSIONS: We found an elevated risk of obesity in the middle-aged offspring of either parent with SMI, especially in the offspring of mothers with SMI. Thus, there might be a common familial pathway leading to the co-occurrence of obesity and SMI. |
format |
Text |
author |
Protsenko, Maria Kerkelä, Martta Miettunen, Jouko Auvinen, Juha Järvelin, Marjo-Riitta Jones, Peter B. Gissler, Mika Veijola, Juha |
author_facet |
Protsenko, Maria Kerkelä, Martta Miettunen, Jouko Auvinen, Juha Järvelin, Marjo-Riitta Jones, Peter B. Gissler, Mika Veijola, Juha |
author_sort |
Protsenko, Maria |
title |
Body mass index in the middle-aged offspring of parents with severe mental illness |
title_short |
Body mass index in the middle-aged offspring of parents with severe mental illness |
title_full |
Body mass index in the middle-aged offspring of parents with severe mental illness |
title_fullStr |
Body mass index in the middle-aged offspring of parents with severe mental illness |
title_full_unstemmed |
Body mass index in the middle-aged offspring of parents with severe mental illness |
title_sort |
body mass index in the middle-aged offspring of parents with severe mental illness |
publisher |
Cambridge University Press |
publishDate |
2023 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10277759/ http://www.ncbi.nlm.nih.gov/pubmed/35232502 https://doi.org/10.1017/S0033291722000253 |
genre |
Northern Finland Lapland |
genre_facet |
Northern Finland Lapland |
op_source |
Psychol Med |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10277759/ http://www.ncbi.nlm.nih.gov/pubmed/35232502 http://dx.doi.org/10.1017/S0033291722000253 |
op_rights |
© The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited. |
op_doi |
https://doi.org/10.1017/S0033291722000253 |
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Psychological Medicine |
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53 |
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8 |
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3621 |
op_container_end_page |
3627 |
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1771548639076810752 |