Serum vaccine antibody concentrations in adults exposed to per- and polyfluoroalkyl substances: A birth cohort in the Faroe Islands
Per- and polyfluoroalkyl substances (PFASs) are highly persistent in the environment and may cause depressed immune function. Previous studies have linked PFAS exposure to lower vaccine responses in children, but research in adults is limited. Therefore, the present study evaluated the associations...
Published in: | Journal of Immunotoxicology |
---|---|
Main Authors: | , , , , , , , |
Format: | Text |
Language: | English |
Published: |
2021
|
Subjects: | |
Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10204592/ http://www.ncbi.nlm.nih.gov/pubmed/34143710 https://doi.org/10.1080/1547691X.2021.1922957 |
id |
ftpubmed:oai:pubmedcentral.nih.gov:10204592 |
---|---|
record_format |
openpolar |
spelling |
ftpubmed:oai:pubmedcentral.nih.gov:10204592 2023-06-11T04:11:36+02:00 Serum vaccine antibody concentrations in adults exposed to per- and polyfluoroalkyl substances: A birth cohort in the Faroe Islands Shih, Yu-Hsuan Blomberg, Annelise J. Bind, Marie-Abèle Holm, Dorte Nielsen, Flemming Heilmann, Carsten Weihe, Pál Grandjean, Philippe 2021-12 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10204592/ http://www.ncbi.nlm.nih.gov/pubmed/34143710 https://doi.org/10.1080/1547691X.2021.1922957 en eng http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10204592/ http://www.ncbi.nlm.nih.gov/pubmed/34143710 http://dx.doi.org/10.1080/1547691X.2021.1922957 https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. J Immunotoxicol Article Text 2021 ftpubmed https://doi.org/10.1080/1547691X.2021.1922957 2023-05-28T00:56:22Z Per- and polyfluoroalkyl substances (PFASs) are highly persistent in the environment and may cause depressed immune function. Previous studies have linked PFAS exposure to lower vaccine responses in children, but research in adults is limited. Therefore, the present study evaluated the associations between exposure to PFASs and serum antibody concentrations in adults vaccinated at age 28 years in the Faroe Islands. PFAS concentrations were determined from cord-blood collected at birth and serum samples collected at ages 7, 14, 22, and 28 years. Serum antibody concentrations against hepatitis type A and B, diphtheria, and tetanus were analyzed from blood samples collected about 6 mo after the first vaccine inoculation at age 28 years. Linear regression models were used to estimate changes in antibody concentration for each doubling of PFAS concentration. Potential effect modification by sex was assessed by including an interaction term between PFAS and sex. Although the 95% confidence intervals contain the null value, inverse trends were observed between serum perfluorooctanoate (PFOA) at ages 14 and 28 years and hepatitis type A antibody (anti-HAV) concentrations, as revealed by an estimated decrease of 0.71 (95% CI: −1.52, 0.09) and 0.24 (95% CI: −0.59, 0.10) signal-to-cutoff ratio for each doubling of exposure, respectively. Inverse trends were also observed between serum PFOA at ages 22 and 28 years and hepatitis type B antibody (anti-HBs) concentration, with an estimated decrease of 21% (95% CI: −42.20%, 7.34%) and of 17% (95% CI: −35.47%, 7.35%) in anti-HBs for each doubling of exposure, respectively. Sex-specific associations with anti-HAV were observed for cord-blood PFASs and serum PFAS concentrations at ages 7 and 14 years. No inverse associations of PFAS exposure were found with diphtheria and tetanus antibody concentrations. Future studies are needed to confirm these findings and further investigate the effects of PFASs on adult immune function. Text Faroe Islands PubMed Central (PMC) Faroe Islands Journal of Immunotoxicology 18 1 85 92 |
institution |
Open Polar |
collection |
PubMed Central (PMC) |
op_collection_id |
ftpubmed |
language |
English |
topic |
Article |
spellingShingle |
Article Shih, Yu-Hsuan Blomberg, Annelise J. Bind, Marie-Abèle Holm, Dorte Nielsen, Flemming Heilmann, Carsten Weihe, Pál Grandjean, Philippe Serum vaccine antibody concentrations in adults exposed to per- and polyfluoroalkyl substances: A birth cohort in the Faroe Islands |
topic_facet |
Article |
description |
Per- and polyfluoroalkyl substances (PFASs) are highly persistent in the environment and may cause depressed immune function. Previous studies have linked PFAS exposure to lower vaccine responses in children, but research in adults is limited. Therefore, the present study evaluated the associations between exposure to PFASs and serum antibody concentrations in adults vaccinated at age 28 years in the Faroe Islands. PFAS concentrations were determined from cord-blood collected at birth and serum samples collected at ages 7, 14, 22, and 28 years. Serum antibody concentrations against hepatitis type A and B, diphtheria, and tetanus were analyzed from blood samples collected about 6 mo after the first vaccine inoculation at age 28 years. Linear regression models were used to estimate changes in antibody concentration for each doubling of PFAS concentration. Potential effect modification by sex was assessed by including an interaction term between PFAS and sex. Although the 95% confidence intervals contain the null value, inverse trends were observed between serum perfluorooctanoate (PFOA) at ages 14 and 28 years and hepatitis type A antibody (anti-HAV) concentrations, as revealed by an estimated decrease of 0.71 (95% CI: −1.52, 0.09) and 0.24 (95% CI: −0.59, 0.10) signal-to-cutoff ratio for each doubling of exposure, respectively. Inverse trends were also observed between serum PFOA at ages 22 and 28 years and hepatitis type B antibody (anti-HBs) concentration, with an estimated decrease of 21% (95% CI: −42.20%, 7.34%) and of 17% (95% CI: −35.47%, 7.35%) in anti-HBs for each doubling of exposure, respectively. Sex-specific associations with anti-HAV were observed for cord-blood PFASs and serum PFAS concentrations at ages 7 and 14 years. No inverse associations of PFAS exposure were found with diphtheria and tetanus antibody concentrations. Future studies are needed to confirm these findings and further investigate the effects of PFASs on adult immune function. |
format |
Text |
author |
Shih, Yu-Hsuan Blomberg, Annelise J. Bind, Marie-Abèle Holm, Dorte Nielsen, Flemming Heilmann, Carsten Weihe, Pál Grandjean, Philippe |
author_facet |
Shih, Yu-Hsuan Blomberg, Annelise J. Bind, Marie-Abèle Holm, Dorte Nielsen, Flemming Heilmann, Carsten Weihe, Pál Grandjean, Philippe |
author_sort |
Shih, Yu-Hsuan |
title |
Serum vaccine antibody concentrations in adults exposed to per- and polyfluoroalkyl substances: A birth cohort in the Faroe Islands |
title_short |
Serum vaccine antibody concentrations in adults exposed to per- and polyfluoroalkyl substances: A birth cohort in the Faroe Islands |
title_full |
Serum vaccine antibody concentrations in adults exposed to per- and polyfluoroalkyl substances: A birth cohort in the Faroe Islands |
title_fullStr |
Serum vaccine antibody concentrations in adults exposed to per- and polyfluoroalkyl substances: A birth cohort in the Faroe Islands |
title_full_unstemmed |
Serum vaccine antibody concentrations in adults exposed to per- and polyfluoroalkyl substances: A birth cohort in the Faroe Islands |
title_sort |
serum vaccine antibody concentrations in adults exposed to per- and polyfluoroalkyl substances: a birth cohort in the faroe islands |
publishDate |
2021 |
url |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10204592/ http://www.ncbi.nlm.nih.gov/pubmed/34143710 https://doi.org/10.1080/1547691X.2021.1922957 |
geographic |
Faroe Islands |
geographic_facet |
Faroe Islands |
genre |
Faroe Islands |
genre_facet |
Faroe Islands |
op_source |
J Immunotoxicol |
op_relation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10204592/ http://www.ncbi.nlm.nih.gov/pubmed/34143710 http://dx.doi.org/10.1080/1547691X.2021.1922957 |
op_rights |
https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
op_doi |
https://doi.org/10.1080/1547691X.2021.1922957 |
container_title |
Journal of Immunotoxicology |
container_volume |
18 |
container_issue |
1 |
container_start_page |
85 |
op_container_end_page |
92 |
_version_ |
1768386778962591744 |